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Secondary Myelodysplastic Syndrome

MedGen UID:
76156
•Concept ID:
C0280745
•
Neoplastic Process
Synonym: Secondary MDS

Definition

A myelodysplastic syndrome resulting from chemotherapy or radiation therapy treatment for other malignant disorders. [from NCI]

Professional guidelines

PubMed

Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis.
Putzki N, Knipp S, Ramczykowski T, Vago S, Germing U, Diener HC, Limmroth V
Mult Scler 2006 Jun;12(3):363-6. doi: 10.1191/135248506ms1307cr. PMID: 16764353
Late toxicity following curative treatment of testicular cancer.
Kollmannsberger C, Kuzcyk M, Mayer F, Hartmann JT, Kanz L, Bokemeyer C
Semin Surg Oncol 1999 Dec;17(4):275-81. doi: 10.1002/(sici)1098-2388(199912)17:4<275::aid-ssu9>3.0.co;2-u. PMID: 10588857

Recent clinical studies

Etiology

Vemurafenib combined with cladribine and cytarabine results in durable remission of pediatric BRAF V600E-positive LCH.
Evseev D, Osipova D, Kalinina I, Raykina E, Ignatova A, Lyudovskikh E, Baidildina D, Popov A, Zhogov V, Semchenkova A, Litvin E, Kotskaya N, Cherniak E, Voronin K, Burtsev E, Bronin G, Vlasova I, Purbueva B, Fink O, Pristanskova E, Dzhukaeva I, Erega E, Novichkova G, Maschan A, Maschan M
Blood Adv 2023 Sep 26;7(18):5246-5257. doi: 10.1182/bloodadvances.2022009067. PMID: 37216396Free PMC Article
Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748

Diagnosis

Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Evolution of clonal cytogenetic abnormalities in aplastic anemia.
Maciejewski JP, Selleri C
Leuk Lymphoma 2004 Mar;45(3):433-40. doi: 10.1080/10428190310001602363. PMID: 15160903
Secondary myelodysplastic syndrome and acute myelogenous leukemia are significant complications following autologous stem cell transplantation for lymphoma.
Howe R, Micallef IN, Inwards DJ, Ansell SM, Dewald GW, Dispenzieri A, Gastineau DA, Gertz MA, Geyer SM, Hanson CA, Lacy MQ, Tefferi A, Litzow MR
Bone Marrow Transplant 2003 Aug;32(3):317-24. doi: 10.1038/sj.bmt.1704124. PMID: 12858205
The myelodysplastic syndromes.
Verwilghen RL, Boogaerts MA
Blood Rev 1987 Mar;1(1):34-43. doi: 10.1016/0268-960x(87)90017-8. PMID: 3332085

Therapy

Vemurafenib combined with cladribine and cytarabine results in durable remission of pediatric BRAF V600E-positive LCH.
Evseev D, Osipova D, Kalinina I, Raykina E, Ignatova A, Lyudovskikh E, Baidildina D, Popov A, Zhogov V, Semchenkova A, Litvin E, Kotskaya N, Cherniak E, Voronin K, Burtsev E, Bronin G, Vlasova I, Purbueva B, Fink O, Pristanskova E, Dzhukaeva I, Erega E, Novichkova G, Maschan A, Maschan M
Blood Adv 2023 Sep 26;7(18):5246-5257. doi: 10.1182/bloodadvances.2022009067. PMID: 37216396Free PMC Article
Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Fludarabine: a review of the clear benefits and potential harms.
Lukenbill J, Kalaycio M
Leuk Res 2013 Sep;37(9):986-94. Epub 2013 Jun 17 doi: 10.1016/j.leukres.2013.05.004. PMID: 23787174
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748

Prognosis

Vemurafenib combined with cladribine and cytarabine results in durable remission of pediatric BRAF V600E-positive LCH.
Evseev D, Osipova D, Kalinina I, Raykina E, Ignatova A, Lyudovskikh E, Baidildina D, Popov A, Zhogov V, Semchenkova A, Litvin E, Kotskaya N, Cherniak E, Voronin K, Burtsev E, Bronin G, Vlasova I, Purbueva B, Fink O, Pristanskova E, Dzhukaeva I, Erega E, Novichkova G, Maschan A, Maschan M
Blood Adv 2023 Sep 26;7(18):5246-5257. doi: 10.1182/bloodadvances.2022009067. PMID: 37216396Free PMC Article
Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Fludarabine: a review of the clear benefits and potential harms.
Lukenbill J, Kalaycio M
Leuk Res 2013 Sep;37(9):986-94. Epub 2013 Jun 17 doi: 10.1016/j.leukres.2013.05.004. PMID: 23787174
The myelodysplastic syndromes.
Verwilghen RL, Boogaerts MA
Blood Rev 1987 Mar;1(1):34-43. doi: 10.1016/0268-960x(87)90017-8. PMID: 3332085

Clinical prediction guides

Vemurafenib combined with cladribine and cytarabine results in durable remission of pediatric BRAF V600E-positive LCH.
Evseev D, Osipova D, Kalinina I, Raykina E, Ignatova A, Lyudovskikh E, Baidildina D, Popov A, Zhogov V, Semchenkova A, Litvin E, Kotskaya N, Cherniak E, Voronin K, Burtsev E, Bronin G, Vlasova I, Purbueva B, Fink O, Pristanskova E, Dzhukaeva I, Erega E, Novichkova G, Maschan A, Maschan M
Blood Adv 2023 Sep 26;7(18):5246-5257. doi: 10.1182/bloodadvances.2022009067. PMID: 37216396Free PMC Article
Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.
Wojdyla T, Mehta H, Glaubach T, Bertolusso R, Iwanaszko M, Braun R, Corey SJ, Kimmel M
PLoS Comput Biol 2019 Jan;15(1):e1006664. Epub 2019 Jan 7 doi: 10.1371/journal.pcbi.1006664. PMID: 30615612Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Evolution of clonal cytogenetic abnormalities in aplastic anemia.
Maciejewski JP, Selleri C
Leuk Lymphoma 2004 Mar;45(3):433-40. doi: 10.1080/10428190310001602363. PMID: 15160903
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748

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