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Luminal A breast carcinoma

MedGen UID:
770985
•Concept ID:
C3642345
•
Neoplastic Process
Synonyms: Luminal A; Luminal A Breast Cancer; Luminal A breast cancer; Luminal A Breast Carcinoma; luminal A breast carcinoma; Luminal A Estrogen Receptor Positive Subtype of Breast Carcinoma; Luminal A estrogen receptor positive subtype of breast carcinoma; Luminal A oestrogen receptor positive subtype of breast carcinoma; Luminal A Subtype of Breast Carcinoma; Luminal A subtype of breast carcinoma
 
Monarch Initiative: MONDO:0021116

Definition

A biologic subset of breast carcinoma defined by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3. This subtype of breast cancer is associated with a good prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLuminal A breast carcinoma

Professional guidelines

PubMed

CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review).
Huang J, Zheng L, Sun Z, Li J
Int J Mol Med 2022 Oct;50(4) Epub 2022 Aug 31 doi: 10.3892/ijmm.2022.5184. PMID: 36043521Free PMC Article
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.
Jiang YZ, Ma D, Suo C, Shi J, Xue M, Hu X, Xiao Y, Yu KD, Liu YR, Yu Y, Zheng Y, Li X, Zhang C, Hu P, Zhang J, Hua Q, Zhang J, Hou W, Ren L, Bao D, Li B, Yang J, Yao L, Zuo WJ, Zhao S, Gong Y, Ren YX, Zhao YX, Yang YS, Niu Z, Cao ZG, Stover DG, Verschraegen C, Kaklamani V, Daemen A, Benson JR, Takabe K, Bai F, Li DQ, Wang P, Shi L, Huang W, Shao ZM
Cancer Cell 2019 Mar 18;35(3):428-440.e5. Epub 2019 Mar 7 doi: 10.1016/j.ccell.2019.02.001. PMID: 30853353
Luminal B breast cancer: molecular characterization, clinical management, and future perspectives.
Ades F, Zardavas D, Bozovic-Spasojevic I, Pugliano L, Fumagalli D, de Azambuja E, Viale G, Sotiriou C, Piccart M
J Clin Oncol 2014 Sep 1;32(25):2794-803. Epub 2014 Jul 21 doi: 10.1200/JCO.2013.54.1870. PMID: 25049332

Recent clinical studies

Etiology

Invasive lobular carcinoma: an understudied emergent subtype of breast cancer.
Mouabbi JA, Hassan A, Lim B, Hortobagyi GN, Tripathy D, Layman RM
Breast Cancer Res Treat 2022 Jun;193(2):253-264. Epub 2022 Mar 26 doi: 10.1007/s10549-022-06572-w. PMID: 35347549
Predicting the molecular subtype of breast cancer and identifying interpretable imaging features using machine learning algorithms.
Ma M, Liu R, Wen C, Xu W, Xu Z, Wang S, Wu J, Pan D, Zheng B, Qin G, Chen W
Eur Radiol 2022 Mar;32(3):1652-1662. Epub 2021 Oct 13 doi: 10.1007/s00330-021-08271-4. PMID: 34647174
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lønning PE, Brown PO, Børresen-Dale AL, Botstein D
Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8418-23. Epub 2003 Jun 26 doi: 10.1073/pnas.0932692100. PMID: 12829800Free PMC Article
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Diagnosis

Invasive lobular carcinoma: an understudied emergent subtype of breast cancer.
Mouabbi JA, Hassan A, Lim B, Hortobagyi GN, Tripathy D, Layman RM
Breast Cancer Res Treat 2022 Jun;193(2):253-264. Epub 2022 Mar 26 doi: 10.1007/s10549-022-06572-w. PMID: 35347549
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR
Breast Cancer Res 2021 Jan 7;23(1):6. doi: 10.1186/s13058-020-01384-6. PMID: 33413533Free PMC Article
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article

Therapy

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.
Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J; I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ
Cancer Cell 2022 Jun 13;40(6):609-623.e6. Epub 2022 May 26 doi: 10.1016/j.ccell.2022.05.005. PMID: 35623341Free PMC Article
Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.
Denkert C, von Minckwitz G, Darb-Esfahani S, Lederer B, Heppner BI, Weber KE, Budczies J, Huober J, Klauschen F, Furlanetto J, Schmitt WD, Blohmer JU, Karn T, Pfitzner BM, Kümmel S, Engels K, Schneeweiss A, Hartmann A, Noske A, Fasching PA, Jackisch C, van Mackelenbergh M, Sinn P, Schem C, Hanusch C, Untch M, Loibl S
Lancet Oncol 2018 Jan;19(1):40-50. Epub 2017 Dec 7 doi: 10.1016/S1470-2045(17)30904-X. PMID: 29233559
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
Eroles P, Bosch A, Pérez-Fidalgo JA, Lluch A
Cancer Treat Rev 2012 Oct;38(6):698-707. Epub 2011 Dec 16 doi: 10.1016/j.ctrv.2011.11.005. PMID: 22178455
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA
J Clin Invest 2011 Jul;121(7):2750-67. doi: 10.1172/JCI45014. PMID: 21633166Free PMC Article

Prognosis

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Invasive lobular carcinoma: an understudied emergent subtype of breast cancer.
Mouabbi JA, Hassan A, Lim B, Hortobagyi GN, Tripathy D, Layman RM
Breast Cancer Res Treat 2022 Jun;193(2):253-264. Epub 2022 Mar 26 doi: 10.1007/s10549-022-06572-w. PMID: 35347549
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Predicting the molecular subtype of breast cancer and identifying interpretable imaging features using machine learning algorithms.
Ma M, Liu R, Wen C, Xu W, Xu Z, Wang S, Wu J, Pan D, Zheng B, Qin G, Chen W
Eur Radiol 2022 Mar;32(3):1652-1662. Epub 2021 Oct 13 doi: 10.1007/s00330-021-08271-4. PMID: 34647174
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lønning PE, Brown PO, Børresen-Dale AL, Botstein D
Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8418-23. Epub 2003 Jun 26 doi: 10.1073/pnas.0932692100. PMID: 12829800Free PMC Article

Recent systematic reviews

Risk factors for developing both primary breast and primary ovarian cancer: A systematic review.
Ferris JS, Morgan DA, Tseng AS, Terry MB, Ottman R, Hur C, Wright JD, Genkinger JM
Crit Rev Oncol Hematol 2023 Oct;190:104081. Epub 2023 Aug 2 doi: 10.1016/j.critrevonc.2023.104081. PMID: 37541535
Association of reproductive risk factors and breast cancer molecular subtypes: a systematic review and meta-analysis.
Mao X, Omeogu C, Karanth S, Joshi A, Meernik C, Wilson L, Clark A, Deveaux A, He C, Johnson T, Barton K, Kaplan S, Akinyemiju T
BMC Cancer 2023 Jul 10;23(1):644. doi: 10.1186/s12885-023-11049-0. PMID: 37430191Free PMC Article
Intermittent Fasting in Breast Cancer: A Systematic Review and Critical Update of Available Studies.
Anemoulis M, Vlastos A, Kachtsidis V, Karras SN
Nutrients 2023 Jan 19;15(3) doi: 10.3390/nu15030532. PMID: 36771239Free PMC Article
Axillary Pathologic Complete Response After Neoadjuvant Systemic Therapy by Breast Cancer Subtype in Patients With Initially Clinically Node-Positive Disease: A Systematic Review and Meta-analysis.
Samiei S, Simons JM, Engelen SME, Beets-Tan RGH, Classe JM, Smidt ML; EUBREAST Group
JAMA Surg 2021 Jun 1;156(6):e210891. Epub 2021 Jun 9 doi: 10.1001/jamasurg.2021.0891. PMID: 33881478Free PMC Article
Established breast cancer risk factors and risk of intrinsic tumor subtypes.
Barnard ME, Boeke CE, Tamimi RM
Biochim Biophys Acta 2015 Aug;1856(1):73-85. Epub 2015 Jun 10 doi: 10.1016/j.bbcan.2015.06.002. PMID: 26071880

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