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Alopecia, congenital(ALPC)

MedGen UID:
78581
Concept ID:
C0265992
Congenital Abnormality
Synonym: Congenital alopecia X-linked
SNOMED CT: Atrichia congenita (403798006); Nevoid congenital alopecia (2965006); Congenital alopecia (2965006); Congenital atrichosis (2965006)
 
Monarch Initiative: MONDO:0010229
OMIM®: 300042

Definition

A congenital condition characterized by the absence of hair on the scalp or entire body. The lack of hair is rarely absolute and is usually accompanied by incompletely grown, lanugo-like hair. It affects males twice as much as females and a familial tendency is common. [from NCI]

Professional guidelines

PubMed

Bachmann AS, VanSickle EA, Michael J, Vipond M, Bupp CP
Dev Med Child Neurol 2024 Apr;66(4):445-455. Epub 2023 Jul 19 doi: 10.1111/dmcn.15687. PMID: 37469105Free PMC Article
Matza Porges S, Mor-Shaked H, Shaag A, Porat S, Daum H
Eur J Med Genet 2023 Oct;66(10):104825. Epub 2023 Sep 1 doi: 10.1016/j.ejmg.2023.104825. PMID: 37659595
Castelo-Soccio L
Pediatr Clin North Am 2014 Apr;61(2):427-42. Epub 2014 Jan 21 doi: 10.1016/j.pcl.2013.12.002. PMID: 24636654

Recent clinical studies

Etiology

Serra G, Memo L, Cavicchioli P, Cutrone M, Giuffrè M, La Torre ML, Schierz IAM, Corsello G
Ital J Pediatr 2022 Aug 13;48(1):145. doi: 10.1186/s13052-022-01336-0. PMID: 35964051Free PMC Article
Calvieri S, Rossi A
G Ital Dermatol Venereol 2014 Feb;149(1):1-13. PMID: 24566562
Stratigos AJ, Baden HP
Arch Dermatol 2001 Nov;137(11):1465-71. doi: 10.1001/archderm.137.11.1465. PMID: 11708949
Ahmad W, Panteleyev A, Christiano AM
Cutis 1999 Oct;64(4):269-76. PMID: 10544884
Birnbaum PS, Baden HP
Dermatol Clin 1987 Jan;5(1):137-53. PMID: 3549074

Diagnosis

Al-Dawsari NA, Kaliyadan F
Skinmed 2018;16(1):27-32. Epub 2018 Feb 1 PMID: 29551108
Castelo-Soccio L
Pediatr Clin North Am 2014 Apr;61(2):427-42. Epub 2014 Jan 21 doi: 10.1016/j.pcl.2013.12.002. PMID: 24636654
Moreno-Romero JA, Grimalt R
G Ital Dermatol Venereol 2014 Feb;149(1):55-78. PMID: 24566566
Lencastre A, Tosti A
Pediatr Dermatol 2013 Nov-Dec;30(6):674-82. Epub 2013 Aug 13 doi: 10.1111/pde.12173. PMID: 23937326
Bennàssar A, Ferrando J, Grimalt R
World J Pediatr 2011 May;7(2):111-7. Epub 2011 May 15 doi: 10.1007/s12519-011-0262-z. PMID: 21574026

Therapy

Fernández-Crehuet P, Vaño-Galván S, Martorell-Calatayud A, Arias-Santiago S, Grimalt R, Camacho-Martínez FM
J Am Acad Dermatol 2016 Sep;75(3):634-637. doi: 10.1016/j.jaad.2016.04.053. PMID: 27543220
Okada Y, Hamano K, Iwasaki N, Iijima S, Anno I
Childs Nerv Syst 1998 Apr-May;14(4-5):218-21. doi: 10.1007/s003810050215. PMID: 9660127
Armstrong DK, Burrows D
Pediatr Dermatol 1996 Sep-Oct;13(5):394-6. doi: 10.1111/j.1525-1470.1996.tb00708.x. PMID: 8893240
Leighton WD, Johnson ML, Friedland JA
Plast Reconstr Surg 1986 May;77(5):737-43. doi: 10.1097/00006534-198605000-00006. PMID: 3703997

Prognosis

Serra G, Memo L, Cavicchioli P, Cutrone M, Giuffrè M, La Torre ML, Schierz IAM, Corsello G
Ital J Pediatr 2022 Aug 13;48(1):145. doi: 10.1186/s13052-022-01336-0. PMID: 35964051Free PMC Article
Arif T, Adil M, Amin SS
Acta Dermatovenerol Alp Pannonica Adriat 2018 Mar;27(1):35-36. PMID: 29589644
Kamalpour L, Gammon B, Chen KH, Veledar E, Pavlis M, Rice ZP, Chen SC
Pediatr Dermatol 2011 Sep-Oct;28(5):512-8. Epub 2011 Sep 5 doi: 10.1111/j.1525-1470.2011.01432.x. PMID: 21895756
Ahmad W, Panteleyev A, Christiano AM
Cutis 1999 Oct;64(4):269-76. PMID: 10544884
Keyvani K, Paulus W, Traupe H, Kiesewetter F, Cursiefen C, Huk W, Raab K, Orth U, Rauch A, Pfeiffer RA
Am J Med Genet 1998 Jul 24;78(4):371-7. doi: 10.1002/(sici)1096-8628(19980724)78:4<371::aid-ajmg13>3.0.co;2-f. PMID: 9714442

Clinical prediction guides

Kamalpour L, Gammon B, Chen KH, Veledar E, Pavlis M, Rice ZP, Chen SC
Pediatr Dermatol 2011 Sep-Oct;28(5):512-8. Epub 2011 Sep 5 doi: 10.1111/j.1525-1470.2011.01432.x. PMID: 21895756
Zlotogorski A, Panteleyev AA, Aita VM, Christiano AM
J Invest Dermatol 2002 May;118(5):887-90. doi: 10.1046/j.1523-1747.2001.01767.x. PMID: 11982770
Zlotogorski A, Panteleyev AA, Aita VM, Christiano AM
J Invest Dermatol 2001 Dec;117(6):1662-5. doi: 10.1046/j.0022-202x.2001.01618.x. PMID: 11886538
Stratigos AJ, Baden HP
Arch Dermatol 2001 Nov;137(11):1465-71. doi: 10.1001/archderm.137.11.1465. PMID: 11708949
Keyvani K, Paulus W, Traupe H, Kiesewetter F, Cursiefen C, Huk W, Raab K, Orth U, Rauch A, Pfeiffer RA
Am J Med Genet 1998 Jul 24;78(4):371-7. doi: 10.1002/(sici)1096-8628(19980724)78:4<371::aid-ajmg13>3.0.co;2-f. PMID: 9714442

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