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Third cranial nerve disorder

MedGen UID:: 78766
•Concept ID:: C0271353
•: Disease or Syndrome

Synonym:	Third cranial nerve disease
SNOMED CT:	Third cranial nerve disease (60750009); Oculomotor nerve disorder (60750009); Third cranial nerve disorder (60750009); Oculomotor nerve disease (60750009)

Monarch Initiative:	MONDO:0003546

Definition

A non-neoplastic or neoplastic disorder affecting the oculomotor nerve (third cranial nerve). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThird cranial nerve disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of nervous system
        Cranial nerve neuropathy
        Third cranial nerve disorder
        Oculomotor nerve neoplasm
        Oculomotor nerve cancer
        Oculomotor nerve palsy
        Congenital oculomotor nerve palsy
        Holmes-Adie syndrome

Professional guidelines

PubMed

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis.

Fritz D, van de Beek D, Brouwer MC
BMC Neurol 2016 Nov 15;16(1):220. doi: 10.1186/s12883-016-0741-x. PMID: 27846819 Free PMC Article

Treatment and diagnosis of congenital fourth nerve palsies: an update.

Engel JM
Curr Opin Ophthalmol 2015 Jul;26(5):353-6. doi: 10.1097/ICU.0000000000000179. PMID: 26247132

CANVAS an update: clinical presentation, investigation and management.

Szmulewicz DJ, McLean CA, MacDougall HG, Roberts L, Storey E, Halmagyi GM
J Vestib Res 2014;24(5-6):465-74. doi: 10.3233/VES-140536. PMID: 25564090

See all (55)

Recent clinical studies

Etiology

Spontaneous subarachnoid haemorrhage.

Claassen J, Park S
Lancet 2022 Sep 10;400(10355):846-862. Epub 2022 Aug 16 doi: 10.1016/S0140-6736(22)00938-2. PMID: 35985353 Free PMC Article

Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial.

Johansson ME, Cameron IGM, Van der Kolk NM, de Vries NM, Klimars E, Toni I, Bloem BR, Helmich RC
Ann Neurol 2022 Feb;91(2):203-216. Epub 2022 Jan 19 doi: 10.1002/ana.26291. PMID: 34951063 Free PMC Article

Approach to patient with diplopia.

Margolin E
J Neurol Sci 2020 Oct 15;417:117055. Epub 2020 Aug 5 doi: 10.1016/j.jns.2020.117055. PMID: 32777577

Recessive ataxias.

Synofzik M, Németh AH
Handb Clin Neurol 2018;155:73-89. doi: 10.1016/B978-0-444-64189-2.00005-6. PMID: 29891078

Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.

Tamhankar MA, Biousse V, Ying GS, Prasad S, Subramanian PS, Lee MS, Eggenberger E, Moss HE, Pineles S, Bennett J, Osborne B, Volpe NJ, Liu GT, Bruce BB, Newman NJ, Galetta SL, Balcer LJ
Ophthalmology 2013 Nov;120(11):2264-9. Epub 2013 Jun 6 doi: 10.1016/j.ophtha.2013.04.009. PMID: 23747163 Free PMC Article

See all (590)

Diagnosis

Acute-onset diplopia.

O'Colmain U, Gilmour C, MacEwen CJ
Acta Ophthalmol 2014 Jun;92(4):382-6. Epub 2013 Feb 7 doi: 10.1111/aos.12062. PMID: 23387838

Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.

Paralytic strabismus.

LaRoche GR
Curr Opin Ophthalmol 1999 Oct;10(5):310-3. doi: 10.1097/00055735-199910000-00005. PMID: 10621543

Paralytic strabismus.

Schiavi C
Curr Opin Ophthalmol 1995 Oct;6(5):22-6. doi: 10.1097/00055735-199510000-00005. PMID: 10159715

Neuro-ophthalmology.

Agnetti V
Curr Opin Neurol Neurosurg 1991 Oct;4(5):783-7. PMID: 10148443

See all (1087)

Therapy

Approach to the Patient With Prolactinoma.

Auriemma RS, Pirchio R, Pivonello C, Garifalos F, Colao A, Pivonello R
J Clin Endocrinol Metab 2023 Aug 18;108(9):2400-2423. doi: 10.1210/clinem/dgad174. PMID: 36974474 Free PMC Article

Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial.

Neoplastic meningitis.

Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

Thyroid eye disease.

Scott IU, Siatkowski MR
Semin Ophthalmol 1999 Jun;14(2):52-61. doi: 10.3109/08820539909056064. PMID: 10758212

Paralytic strabismus.

Schiavi C
Curr Opin Ophthalmol 1995 Oct;6(5):22-6. doi: 10.1097/00055735-199510000-00005. PMID: 10159715

See all (366)

Prognosis

Idiopathic third and sixth cranial nerve neuritis.

Park KA, Min JH, Oh SY, Kim BJ
Jpn J Ophthalmol 2019 Jul;63(4):337-343. Epub 2019 Apr 20 doi: 10.1007/s10384-019-00666-7. PMID: 31006061

Intracranial Aneurysms of Neuro-Ophthalmologic Relevance.

Micieli JA, Newman NJ, Barrow DL, Biousse V
J Neuroophthalmol 2017 Dec;37(4):421-439. doi: 10.1097/WNO.0000000000000515. PMID: 28665866

Electrophysiology in Fisher syndrome.

Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188

Ophthalmoplegic migraine.

Levin M, Ward TN
Curr Pain Headache Rep 2004 Aug;8(4):306-9. doi: 10.1007/s11916-004-0013-0. PMID: 15228891

Neoplastic meningitis.

Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

See all (430)

Clinical prediction guides

Approach to patient with diplopia.

Margolin E
J Neurol Sci 2020 Oct 15;417:117055. Epub 2020 Aug 5 doi: 10.1016/j.jns.2020.117055. PMID: 32777577

Idiopathic third and sixth cranial nerve neuritis.

Park KA, Min JH, Oh SY, Kim BJ
Jpn J Ophthalmol 2019 Jul;63(4):337-343. Epub 2019 Apr 20 doi: 10.1007/s10384-019-00666-7. PMID: 31006061

Intracranial Aneurysms of Neuro-Ophthalmologic Relevance.

Micieli JA, Newman NJ, Barrow DL, Biousse V
J Neuroophthalmol 2017 Dec;37(4):421-439. doi: 10.1097/WNO.0000000000000515. PMID: 28665866

Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study.

Ophthalmoplegic migraine.

Levin M, Ward TN
Curr Pain Headache Rep 2004 Aug;8(4):306-9. doi: 10.1007/s11916-004-0013-0. PMID: 15228891

See all (360)

Recent systematic reviews

Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis.

Palaiodimou L, Stefanou MI, Katsanos AH, Fragkou PC, Papadopoulou M, Moschovos C, Michopoulos I, Kokotis P, Bakirtzis C, Naska A, Vassilakopoulos TI, Chroni E, Tsiodras S, Tsivgoulis G
Eur J Neurol 2021 Oct;28(10):3517-3529. Epub 2021 Apr 28 doi: 10.1111/ene.14860. PMID: 33837630 Free PMC Article

Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.

Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162

Sarcomas of the sellar region: a systematic review.

Guerrero-Pérez F, Vidal N, López-Vázquez M, Sánchez-Barrera R, Sánchez-Fernández JJ, Torres-Díaz A, Vilarrasa N, Villabona C
Pituitary 2021 Feb;24(1):117-129. doi: 10.1007/s11102-020-01073-9. PMID: 32785833

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis.

Fritz D, van de Beek D, Brouwer MC
BMC Neurol 2016 Nov 15;16(1):220. doi: 10.1186/s12883-016-0741-x. PMID: 27846819 Free PMC Article

Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation.

Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487

See all (17)

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Third cranial nerve disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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