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Stage IV Kidney Wilms Tumor

MedGen UID:
78871
Concept ID:
C0278714
Neoplastic Process
Synonyms: Stage IV Kidney Nephroblastoma; Stage IV Renal Wilms Tumor; Stage IV Renal Wilms' Tumor

Definition

Wilms tumor that has spread to other more distant organs, such as the lungs, liver, bones, and brain, or to lymph nodes outside the abdomen (National Wilms Tumor Study Group Staging System) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Kidney Wilms Tumor

Professional guidelines

PubMed

Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):437-445. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2305-5. PMID: 28367612
Dome JS, Graf N, Geller JI, Fernandez CV, Mullen EA, Spreafico F, Van den Heuvel-Eibrink M, Pritchard-Jones K
J Clin Oncol 2015 Sep 20;33(27):2999-3007. Epub 2015 Aug 24 doi: 10.1200/JCO.2015.62.1888. PMID: 26304882Free PMC Article

Recent clinical studies

Etiology

Madanat-Harjuoja LM, Renfro LA, Klega K, Tornwall B, Thorner AR, Nag A, Dix D, Dome JS, Diller LR, Fernandez CV, Mullen EA, Crompton BD
J Clin Oncol 2022 Sep 10;40(26):3047-3056. Epub 2022 May 17 doi: 10.1200/JCO.22.00098. PMID: 35580298Free PMC Article
Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA, Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Wagner E, Grundy PE, Fernandez CV, Dome JS
J Clin Oncol 2018 Jun 1;36(16):1564-1570. Epub 2018 Apr 16 doi: 10.1200/JCO.2017.77.1931. PMID: 29659330Free PMC Article
Ehrlich P, Chi YY, Chintagumpala MM, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Grundy PE, Fernandez CV, Ritchey ML, Dome JS
Ann Surg 2017 Sep;266(3):470-478. doi: 10.1097/SLA.0000000000002356. PMID: 28795993Free PMC Article
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):437-445. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2305-5. PMID: 28367612
Cabezalí Barbancho D, Guerrero Ramos F, López Vázquez F, Aransay Bramtot A, Gómez Fraile A
Surg Laparosc Endosc Percutan Tech 2014 Feb;24(1):22-5. doi: 10.1097/SLE.0b013e31829cebf1. PMID: 24487153

Diagnosis

Cairo SB, Urias AR, Murphy JT
J Surg Res 2022 Dec;280:396-403. Epub 2022 Aug 26 doi: 10.1016/j.jss.2022.06.046. PMID: 36037617
Madanat-Harjuoja LM, Renfro LA, Klega K, Tornwall B, Thorner AR, Nag A, Dix D, Dome JS, Diller LR, Fernandez CV, Mullen EA, Crompton BD
J Clin Oncol 2022 Sep 10;40(26):3047-3056. Epub 2022 May 17 doi: 10.1200/JCO.22.00098. PMID: 35580298Free PMC Article
Ehrlich P, Chi YY, Chintagumpala MM, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Grundy PE, Fernandez CV, Ritchey ML, Dome JS
Ann Surg 2017 Sep;266(3):470-478. doi: 10.1097/SLA.0000000000002356. PMID: 28795993Free PMC Article
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):437-445. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2305-5. PMID: 28367612
Dome JS, Graf N, Geller JI, Fernandez CV, Mullen EA, Spreafico F, Van den Heuvel-Eibrink M, Pritchard-Jones K
J Clin Oncol 2015 Sep 20;33(27):2999-3007. Epub 2015 Aug 24 doi: 10.1200/JCO.2015.62.1888. PMID: 26304882Free PMC Article

Therapy

Holmes DM, Matatiyo A, Mpasa A, Huibers MHW, Manda G, Tomoka T, Mulenga M, Namazzi R, Mehta P, Zobeck M, Mzikamanda R, Chintagumpala M, Allen C, Nuchtern JG, Borgstein E, Aronson DC, Ozuah N, Nandi B, McAtee CL
Pediatr Blood Cancer 2023 May;70(5):e30242. Epub 2023 Feb 16 doi: 10.1002/pbc.30242. PMID: 36798020Free PMC Article
Madanat-Harjuoja LM, Renfro LA, Klega K, Tornwall B, Thorner AR, Nag A, Dix D, Dome JS, Diller LR, Fernandez CV, Mullen EA, Crompton BD
J Clin Oncol 2022 Sep 10;40(26):3047-3056. Epub 2022 May 17 doi: 10.1200/JCO.22.00098. PMID: 35580298Free PMC Article
Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA, Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Wagner E, Grundy PE, Fernandez CV, Dome JS
J Clin Oncol 2018 Jun 1;36(16):1564-1570. Epub 2018 Apr 16 doi: 10.1200/JCO.2017.77.1931. PMID: 29659330Free PMC Article
Ehrlich P, Chi YY, Chintagumpala MM, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Grundy PE, Fernandez CV, Ritchey ML, Dome JS
Ann Surg 2017 Sep;266(3):470-478. doi: 10.1097/SLA.0000000000002356. PMID: 28795993Free PMC Article
Jürgens H, Treuner J, Winkler K, Göbel U
Semin Oncol 1989 Feb;16(1 Suppl 3):46-50. PMID: 2649985

Prognosis

Madanat-Harjuoja LM, Renfro LA, Klega K, Tornwall B, Thorner AR, Nag A, Dix D, Dome JS, Diller LR, Fernandez CV, Mullen EA, Crompton BD
J Clin Oncol 2022 Sep 10;40(26):3047-3056. Epub 2022 May 17 doi: 10.1200/JCO.22.00098. PMID: 35580298Free PMC Article
Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA, Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Wagner E, Grundy PE, Fernandez CV, Dome JS
J Clin Oncol 2018 Jun 1;36(16):1564-1570. Epub 2018 Apr 16 doi: 10.1200/JCO.2017.77.1931. PMID: 29659330Free PMC Article
Ehrlich P, Chi YY, Chintagumpala MM, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Grundy PE, Fernandez CV, Ritchey ML, Dome JS
Ann Surg 2017 Sep;266(3):470-478. doi: 10.1097/SLA.0000000000002356. PMID: 28795993Free PMC Article
Zdrojowy R, Sawicz-Birkowska K, Apoznański W, Patkowski D, Szydełko T, Pietras W, Dembowski J
Int Urol Nephrol 2011 Sep;43(3):691-6. Epub 2010 Nov 26 doi: 10.1007/s11255-010-9868-7. PMID: 21110097
Jürgens H, Treuner J, Winkler K, Göbel U
Semin Oncol 1989 Feb;16(1 Suppl 3):46-50. PMID: 2649985

Clinical prediction guides

Madanat-Harjuoja LM, Renfro LA, Klega K, Tornwall B, Thorner AR, Nag A, Dix D, Dome JS, Diller LR, Fernandez CV, Mullen EA, Crompton BD
J Clin Oncol 2022 Sep 10;40(26):3047-3056. Epub 2022 May 17 doi: 10.1200/JCO.22.00098. PMID: 35580298Free PMC Article
Elayadi M, Magdy S, Khalil E, Zekri W
J Egypt Natl Canc Inst 2020 Apr 15;32(1):19. doi: 10.1186/s43046-020-00031-7. PMID: 32372204
Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA, Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Wagner E, Grundy PE, Fernandez CV, Dome JS
J Clin Oncol 2018 Jun 1;36(16):1564-1570. Epub 2018 Apr 16 doi: 10.1200/JCO.2017.77.1931. PMID: 29659330Free PMC Article
Oue T, Fukuzawa M, Koshinaga T, Okita H, Nozaki M, Chin M, Kaneko Y, Tanaka Y, Haruta M, Tsuchiya K, Kuwajima S, Takimoto T
Pediatr Int 2015 Oct;57(5):828-31. doi: 10.1111/ped.12787. PMID: 26267611
Hadley LG, Rouma BS, Saad-Eldin Y
Semin Pediatr Surg 2012 May;21(2):136-41. doi: 10.1053/j.sempedsurg.2012.01.006. PMID: 22475119

Recent systematic reviews

Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Fuchs J, Murtha-Lemekhova A, Kessler M, Günther P, Hoffmann K
BMC Cancer 2022 Jan 18;22(1):76. doi: 10.1186/s12885-022-09182-3. PMID: 35038991Free PMC Article
Han Q, Li K, Dong K, Xiao X, Yao W, Liu G
J Pediatr Surg 2018 Dec;53(12):2465-2469. Epub 2018 Sep 1 doi: 10.1016/j.jpedsurg.2018.08.022. PMID: 30274708

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