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Intraocular lymphoma

MedGen UID:
79344
•Concept ID:
C0281658
•
Neoplastic Process
Synonyms: Intraocular Lymphoma; Intraocular Lymphomas; Lymphoma, Intraocular; Lymphomas, Intraocular
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0004351
Orphanet: ORPHA279904

Definition

A non-Hodgkin lymphoma that arises within the eyeball. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience.
Min GJ, Kim TY, Jeon YW, O JH, Choi BO, Park G, Park YH, Cho SG
Cancer Med 2023 Apr;12(7):7911-7922. Epub 2023 Jan 31 doi: 10.1002/cam4.5567. PMID: 36721307Free PMC Article
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598

Recent clinical studies

Etiology

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience.
Min GJ, Kim TY, Jeon YW, O JH, Choi BO, Park G, Park YH, Cho SG
Cancer Med 2023 Apr;12(7):7911-7922. Epub 2023 Jan 31 doi: 10.1002/cam4.5567. PMID: 36721307Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Understanding intraocular lymphomas.
Coupland SE, Damato B
Clin Exp Ophthalmol 2008 Aug;36(6):564-78. doi: 10.1111/j.1442-9071.2008.01843.x. PMID: 18954321

Diagnosis

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Intraocular Lymphoma.
Cunningham ET, Miserocchi E, Smith JR, Gonzales JA, Zierhut M
Ocul Immunol Inflamm 2021 Apr 3;29(3):425-429. doi: 10.1080/09273948.2021.1941684. PMID: 34296968
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125
Intraocular lymphoma.
Chan CC, Buggage RR, Nussenblatt RB
Curr Opin Ophthalmol 2002 Dec;13(6):411-8. doi: 10.1097/00055735-200212000-00012. PMID: 12441846

Therapy

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Primary Vitreoretinal Lymphoma in HIV Infection.
Steffen J, Coupland SE, Smith JR
Ocul Immunol Inflamm 2021 Apr 3;29(3):621-627. Epub 2020 May 26 doi: 10.1080/09273948.2020.1751856. PMID: 32453669
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125

Prognosis

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125
Intraocular lymphoma.
Chan CC, Buggage RR, Nussenblatt RB
Curr Opin Ophthalmol 2002 Dec;13(6):411-8. doi: 10.1097/00055735-200212000-00012. PMID: 12441846

Clinical prediction guides

Neuro-Ophthalmic Manifestations of Intracranial Malignancies.
Dermarkarian CR, Kini AT, Al Othman BA, Lee AG
J Neuroophthalmol 2020 Sep;40(3):e31-e48. doi: 10.1097/WNO.0000000000000950. PMID: 32282510
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.
Chaput F, Amer R, Baglivo E, Touitou V, Kozyreff A, Bron D, Bodaghi B, LeHoang P, Bergstrom C, Grossniklaus HE, Chan CC, Pe'er J, Caspers LE
Ocul Immunol Inflamm 2017 Oct;25(5):639-648. Epub 2016 Mar 22 doi: 10.3109/09273948.2016.1139733. PMID: 27002464
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Genetics of primary intraocular tumors.
Nagarkatti-Gude N, Wang Y, Ali MJ, Honavar SG, Jager MJ, Chan CC
Ocul Immunol Inflamm 2012 Aug;20(4):244-54. doi: 10.3109/09273948.2012.702843. PMID: 22834783Free PMC Article

Recent systematic reviews

Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma.
Fox CP, Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, Auer DP, Fuller C, Davies AJ, McKay P, Cwynarski K; British Society for Haematology
Br J Haematol 2019 Feb;184(3):348-363. Epub 2018 Nov 23 doi: 10.1111/bjh.15661. PMID: 30467845

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