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Acute Hemorrhagic Edema of Infancy

MedGen UID:
811126
Concept ID:
C2938937
Disease or Syndrome

Definition

A self-limiting cutaneous vasculitis that typically presents as a clinical triad of purpura, edema, and fever in children between the ages of four months and two years old. It is usually associated with a recent history of upper respiratory infection and/or antibiotic therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Hemorrhagic Edema of Infancy

Recent clinical studies

Etiology

Heck E, Johnson N, Ramien M
Pediatr Dermatol 2021 Jan;38(1):223-225. Epub 2020 Oct 21 doi: 10.1111/pde.14402. PMID: 33085129
Alexopoulos A, Dakoutrou M, Stefanaki K, Chrousos G, Kakourou T
Int J Dermatol 2017 Nov;56(11):1130-1138. Epub 2017 Sep 19 doi: 10.1111/ijd.13749. PMID: 28929493
Parker L, Shahar-Nissan K, Ashkenazi-Hoffnung L, Harel L, Amir J, Trivizki O, Bilavsky E
World J Pediatr 2017 Aug;13(4):341-345. Epub 2017 Apr 29 doi: 10.1007/s12519-017-0032-7. PMID: 28470578
Lee MH, Barnett PL
Pediatr Emerg Care 2012 Jun;28(6):503-5. doi: 10.1097/PEC.0b013e3182586f5f. PMID: 22653463
Jones EM, Callen JP
Pediatr Clin North Am 1991 Aug;38(4):1019-39. doi: 10.1016/s0031-3955(16)38165-2. PMID: 1870902

Diagnosis

Heck E, Johnson N, Ramien M
Pediatr Dermatol 2021 Jan;38(1):223-225. Epub 2020 Oct 21 doi: 10.1111/pde.14402. PMID: 33085129
Gao PR, Yen H, Chen WT
CMAJ 2020 Oct 26;192(43):E1309. doi: 10.1503/cmaj.200418. PMID: 33106303Free PMC Article
Leung AKC, Leong KF, Lam JM
Curr Pediatr Rev 2020;16(4):285-293. doi: 10.2174/1573396316666200727145039. PMID: 32718294
Serra E Moura Garcia C, Sokolova A, Torre ML, Amaro C
Eur Ann Allergy Clin Immunol 2016 Jan;48(1):22-6. PMID: 26808448
AlSufyani MA
Int J Dermatol 2009 Jun;48(6):617-22. doi: 10.1111/j.1365-4632.2009.03917.x. PMID: 19538372

Therapy

Leung AKC, Leong KF, Lam JM
Curr Pediatr Rev 2020;16(4):285-293. doi: 10.2174/1573396316666200727145039. PMID: 32718294
Ceci M, Conrieri M, Raffaldi I, Pagliardini V, Urbino AF
Pediatr Emerg Care 2018 Feb;34(2):e28-e29. doi: 10.1097/PEC.0000000000000749. PMID: 27228147
Binamer Y
Ann Saudi Med 2015 May-Jun;35(3):254-6. doi: 10.5144/0256-4947.2015.254. PMID: 26409801Free PMC Article
Lee MH, Barnett PL
Pediatr Emerg Care 2012 Jun;28(6):503-5. doi: 10.1097/PEC.0b013e3182586f5f. PMID: 22653463
Karremann M, Jordan AJ, Bell N, Witsch M, Dürken M
Clin Pediatr (Phila) 2009 Apr;48(3):323-6. Epub 2008 Sep 4 doi: 10.1177/0009922808323113. PMID: 18772356

Prognosis

Soler-Cardona A, Tanew A, Radakovic S
Acta Dermatovenerol Croat 2021 Dec;29(3):159-163. PMID: 34990345
Ceci M, Conrieri M, Raffaldi I, Pagliardini V, Urbino AF
Pediatr Emerg Care 2018 Feb;34(2):e28-e29. doi: 10.1097/PEC.0000000000000749. PMID: 27228147
Parker L, Shahar-Nissan K, Ashkenazi-Hoffnung L, Harel L, Amir J, Trivizki O, Bilavsky E
World J Pediatr 2017 Aug;13(4):341-345. Epub 2017 Apr 29 doi: 10.1007/s12519-017-0032-7. PMID: 28470578
Sandrine B, Goebeler M
J Dtsch Dermatol Ges 2014 Feb;12(2):124-9. doi: 10.1111/ddg.12252_suppl. PMID: 24494640
AlSufyani MA
Int J Dermatol 2009 Jun;48(6):617-22. doi: 10.1111/j.1365-4632.2009.03917.x. PMID: 19538372

Clinical prediction guides

Leung AKC, Leong KF, Lam JM
Curr Pediatr Rev 2020;16(4):285-293. doi: 10.2174/1573396316666200727145039. PMID: 32718294
Lee MH, Barnett PL
Pediatr Emerg Care 2012 Jun;28(6):503-5. doi: 10.1097/PEC.0b013e3182586f5f. PMID: 22653463
Hughey LC
Dermatol Ther 2011 Mar-Apr;24(2):196-206. doi: 10.1111/j.1529-8019.2011.01395.x. PMID: 21410609
Saraclar Y, Tinaztepe K, Adalioğlu G, Tuncer A
J Allergy Clin Immunol 1990 Oct;86(4 Pt 1):473-83. doi: 10.1016/s0091-6749(05)80202-7. PMID: 2229809

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