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Pulmonary hypertension, neonatal, susceptibility to(PHN)

MedGen UID:
811528
Concept ID:
C3714958
Finding
Synonym: PHN
 
Gene (location): CPS1 (2q34)
 
Monarch Initiative: MONDO:0014151
OMIM®: 615371

Recent clinical studies

Etiology

Arjaans S, Wagner BD, Mourani PM, Mandell EW, Poindexter BB, Berger RMF, Abman SH
Am J Physiol Lung Cell Mol Physiol 2020 Apr 1;318(4):L644-L654. Epub 2020 Jan 22 doi: 10.1152/ajplung.00131.2019. PMID: 31967847Free PMC Article
Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK
Pediatr Res 2020 Jan;87(1):81-87. Epub 2019 Jul 22 doi: 10.1038/s41390-019-0502-9. PMID: 31330530Free PMC Article
Zhang Z, Luo X, Lv Y, Yan L, Xu S, Wang Y, Zhong Y, Hang C, Jyotsnav J, Lai D, Shen Z, Xu X, Ma X, Chen Z, Pan Y, Du L
Hypertension 2019 Nov;74(5):1160-1171. Epub 2019 Oct 9 doi: 10.1161/HYPERTENSIONAHA.119.13634. PMID: 31596625
Chiu JS, Ma L, Wynn J, Krishnan U, Rosenzweig EB, Aspelund G, Arkovitz M, Warner BW, Lim FY, Mychaliska GB, Azarow K, Cusick RA, Chung DH, Chung WK
J Pediatr Surg 2017 Nov;52(11):1747-1750. Epub 2017 Jan 26 doi: 10.1016/j.jpedsurg.2017.01.007. PMID: 28162765
Mei M, Cheng G, Sun B, Yang L, Wang H, Sun J, Zhou W
Sci Rep 2016 Jul 18;6:29877. doi: 10.1038/srep29877. PMID: 27425626Free PMC Article

Diagnosis

Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
Arjaans S, Wagner BD, Mourani PM, Mandell EW, Poindexter BB, Berger RMF, Abman SH
Am J Physiol Lung Cell Mol Physiol 2020 Apr 1;318(4):L644-L654. Epub 2020 Jan 22 doi: 10.1152/ajplung.00131.2019. PMID: 31967847Free PMC Article
Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK
Pediatr Res 2020 Jan;87(1):81-87. Epub 2019 Jul 22 doi: 10.1038/s41390-019-0502-9. PMID: 31330530Free PMC Article
Zhang Z, Luo X, Lv Y, Yan L, Xu S, Wang Y, Zhong Y, Hang C, Jyotsnav J, Lai D, Shen Z, Xu X, Ma X, Chen Z, Pan Y, Du L
Hypertension 2019 Nov;74(5):1160-1171. Epub 2019 Oct 9 doi: 10.1161/HYPERTENSIONAHA.119.13634. PMID: 31596625
Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106

Therapy

Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
Zhang Z, Luo X, Lv Y, Yan L, Xu S, Wang Y, Zhong Y, Hang C, Jyotsnav J, Lai D, Shen Z, Xu X, Ma X, Chen Z, Pan Y, Du L
Hypertension 2019 Nov;74(5):1160-1171. Epub 2019 Oct 9 doi: 10.1161/HYPERTENSIONAHA.119.13634. PMID: 31596625
Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM
Heart 2017 Aug;103(16):1244-1249. Epub 2017 Jan 23 doi: 10.1136/heartjnl-2016-310624. PMID: 28115472
Lopez NC, Ebensperger G, Herrera EA, Reyes RV, Calaf G, Cabello G, Moraga FA, Beñaldo FA, Diaz M, Parer JT, Llanos AJ
Am J Physiol Regul Integr Comp Physiol 2016 Jun 1;310(11):R1053-63. Epub 2016 Feb 24 doi: 10.1152/ajpregu.00177.2015. PMID: 26911462
Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396

Prognosis

Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK
Pediatr Res 2020 Jan;87(1):81-87. Epub 2019 Jul 22 doi: 10.1038/s41390-019-0502-9. PMID: 31330530Free PMC Article
Karolak JA, Szafranski P, Kilner D, Patel C, Scurry B, Kinning E, Chandler K, Jhangiani SN, Coban Akdemir ZH, Lupski JR, Popek E, Stankiewicz P
Clin Genet 2019 Oct;96(4):366-370. Epub 2019 Jul 22 doi: 10.1111/cge.13605. PMID: 31309540Free PMC Article
Chiu JS, Ma L, Wynn J, Krishnan U, Rosenzweig EB, Aspelund G, Arkovitz M, Warner BW, Lim FY, Mychaliska GB, Azarow K, Cusick RA, Chung DH, Chung WK
J Pediatr Surg 2017 Nov;52(11):1747-1750. Epub 2017 Jan 26 doi: 10.1016/j.jpedsurg.2017.01.007. PMID: 28162765
Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM
Heart 2017 Aug;103(16):1244-1249. Epub 2017 Jan 23 doi: 10.1136/heartjnl-2016-310624. PMID: 28115472
Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106

Clinical prediction guides

Silveyra P, Fuentes N, Rodriguez Bauza DE
Adv Exp Med Biol 2021;1304:227-258. doi: 10.1007/978-3-030-68748-9_14. PMID: 34019273Free PMC Article
Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK
Pediatr Res 2020 Jan;87(1):81-87. Epub 2019 Jul 22 doi: 10.1038/s41390-019-0502-9. PMID: 31330530Free PMC Article
Zhang Z, Luo X, Lv Y, Yan L, Xu S, Wang Y, Zhong Y, Hang C, Jyotsnav J, Lai D, Shen Z, Xu X, Ma X, Chen Z, Pan Y, Du L
Hypertension 2019 Nov;74(5):1160-1171. Epub 2019 Oct 9 doi: 10.1161/HYPERTENSIONAHA.119.13634. PMID: 31596625
Karolak JA, Szafranski P, Kilner D, Patel C, Scurry B, Kinning E, Chandler K, Jhangiani SN, Coban Akdemir ZH, Lupski JR, Popek E, Stankiewicz P
Clin Genet 2019 Oct;96(4):366-370. Epub 2019 Jul 22 doi: 10.1111/cge.13605. PMID: 31309540Free PMC Article
Mei M, Cheng G, Sun B, Yang L, Wang H, Sun J, Zhou W
Sci Rep 2016 Jul 18;6:29877. doi: 10.1038/srep29877. PMID: 27425626Free PMC Article

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