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Schizophrenia 18(SCZD18)

MedGen UID:
815243
Concept ID:
C3808913
Mental or Behavioral Dysfunction
Synonym: SCZD18
 
Gene (location): SLC1A1 (9p24.2)
 
Monarch Initiative: MONDO:0014092
OMIM®: 615232

Definition

A schizophrenia that has material basis in a mutation of SLC1A1 on chromosome 9p24.2. [from MONDO]

Professional guidelines

PubMed

Prata DP, Mechelli A, Picchioni MM, Fu CH, Toulopoulou T, Bramon E, Walshe M, Murray RM, Collier DA, McGuire P
Arch Gen Psychiatry 2009 Nov;66(11):1162-72. doi: 10.1001/archgenpsychiatry.2009.147. PMID: 19884604
Milling RN, Faulkner LR, Craig JM
J Subst Abuse Treat 1994 May-Jun;11(3):267-71. doi: 10.1016/0740-5472(94)90085-x. PMID: 8072056

Recent clinical studies

Etiology

Kadakia A, Catillon M, Fan Q, Williams GR, Marden JR, Anderson A, Kirson N, Dembek C
J Clin Psychiatry 2022 Oct 10;83(6) doi: 10.4088/JCP.22m14458. PMID: 36244006
Hagi K, Nosaka T, Dickinson D, Lindenmayer JP, Lee J, Friedman J, Boyer L, Han M, Abdul-Rashid NA, Correll CU
JAMA Psychiatry 2021 May 1;78(5):510-518. doi: 10.1001/jamapsychiatry.2021.0015. PMID: 33656533Free PMC Article
Chen J, Chen R, Xiang S, Li N, Gao C, Wu C, Zhang Q, Zhao Y, Liao Y, Stewart R, Xu Y, Shi Y, Li Z
Br J Psychiatry 2021 Feb;218(2):98-103. doi: 10.1192/bjp.2020.116. PMID: 32552923
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article
Arneth BM
Int J Mol Sci 2017 Aug 12;18(8) doi: 10.3390/ijms18081760. PMID: 28805697Free PMC Article

Diagnosis

Rasmussen AR, Parnas J
Schizophr Res 2022 May;243:1-8. Epub 2022 Feb 23 doi: 10.1016/j.schres.2022.02.014. PMID: 35219003
Hung CC, Lin CH, Lane HY
Int J Mol Sci 2021 Sep 8;22(18) doi: 10.3390/ijms22189718. PMID: 34575878Free PMC Article
Chen J, Chen R, Xiang S, Li N, Gao C, Wu C, Zhang Q, Zhao Y, Liao Y, Stewart R, Xu Y, Shi Y, Li Z
Br J Psychiatry 2021 Feb;218(2):98-103. doi: 10.1192/bjp.2020.116. PMID: 32552923
Kim J, Ozzoude M, Nakajima S, Shah P, Caravaggio F, Iwata Y, De Luca V, Graff-Guerrero A, Gerretsen P
Neuropharmacology 2020 May 15;168:107634. Epub 2019 May 9 doi: 10.1016/j.neuropharm.2019.05.011. PMID: 31077729
Marder SR, Cannon TD
N Engl J Med 2019 Oct 31;381(18):1753-1761. doi: 10.1056/NEJMra1808803. PMID: 31665579

Therapy

Kishimoto T, Hagi K, Kurokawa S, Kane JM, Correll CU
Lancet Psychiatry 2021 May;8(5):387-404. Epub 2021 Apr 13 doi: 10.1016/S2215-0366(21)00039-0. PMID: 33862018
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
Kim J, Ozzoude M, Nakajima S, Shah P, Caravaggio F, Iwata Y, De Luca V, Graff-Guerrero A, Gerretsen P
Neuropharmacology 2020 May 15;168:107634. Epub 2019 May 9 doi: 10.1016/j.neuropharm.2019.05.011. PMID: 31077729
Marder SR, Cannon TD
N Engl J Med 2019 Oct 31;381(18):1753-1761. doi: 10.1056/NEJMra1808803. PMID: 31665579
Geretsegger M, Mössler KA, Bieleninik Ł, Chen XJ, Heldal TO, Gold C
Cochrane Database Syst Rev 2017 May 29;5(5):CD004025. doi: 10.1002/14651858.CD004025.pub4. PMID: 28553702Free PMC Article

Prognosis

Hansen HG, Starzer M, Nilsson SF, Hjorthøj C, Albert N, Nordentoft M
JAMA Psychiatry 2023 Apr 1;80(4):371-379. doi: 10.1001/jamapsychiatry.2022.5164. PMID: 36811902Free PMC Article
Koutsouleris N, Dwyer DB, Degenhardt F, Maj C, Urquijo-Castro MF, Sanfelici R, Popovic D, Oeztuerk O, Haas SS, Weiske J, Ruef A, Kambeitz-Ilankovic L, Antonucci LA, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Kambeitz J, Haidl TK, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Walger P, Franscini M, Traber-Walker N, Schimmelmann BG, Flückiger R, Michel C, Rössler W, Borisov O, Krawitz PM, Heekeren K, Buechler R, Pantelis C, Falkai P, Salokangas RKR, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Theodoridou A, Meisenzahl E; PRONIA Consortium
JAMA Psychiatry 2021 Feb 1;78(2):195-209. doi: 10.1001/jamapsychiatry.2020.3604. PMID: 33263726Free PMC Article
Perkovic MN, Erjavec GN, Strac DS, Uzun S, Kozumplik O, Pivac N
Int J Mol Sci 2017 Mar 30;18(4) doi: 10.3390/ijms18040733. PMID: 28358316Free PMC Article
Hjorthøj C, Stürup AE, McGrath JJ, Nordentoft M
Lancet Psychiatry 2017 Apr;4(4):295-301. Epub 2017 Feb 22 doi: 10.1016/S2215-0366(17)30078-0. PMID: 28237639
Kirkbride JB, Errazuriz A, Croudace TJ, Morgan C, Jackson D, Boydell J, Murray RM, Jones PB
PLoS One 2012;7(3):e31660. Epub 2012 Mar 22 doi: 10.1371/journal.pone.0031660. PMID: 22457710Free PMC Article

Clinical prediction guides

Kang Z, Qin Y, Sun Y, Lu Z, Sun Y, Chen H, Feng X, Zhang Y, Guo H, Yan H, Yue W
JAMA Netw Open 2023 Oct 2;6(10):e2335518. doi: 10.1001/jamanetworkopen.2023.35518. PMID: 37801319Free PMC Article
Guo LK, Su Y, Zhang YY, Yu H, Lu Z, Li WQ, Yang YF, Xiao X, Yan H, Lu TL, Li J, Liao YD, Kang ZW, Wang LF, Li Y, Li M, Liu B, Huang HL, Lv LX, Yao Y, Tan YL, Breen G, Everall I, Wang HX, Huang Z, Zhang D, Yue WH
Mil Med Res 2023 Jun 2;10(1):24. doi: 10.1186/s40779-023-00459-7. PMID: 37269009Free PMC Article
Chen J, Chen R, Xiang S, Li N, Gao C, Wu C, Zhang Q, Zhao Y, Liao Y, Stewart R, Xu Y, Shi Y, Li Z
Br J Psychiatry 2021 Feb;218(2):98-103. doi: 10.1192/bjp.2020.116. PMID: 32552923
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article
Perkovic MN, Erjavec GN, Strac DS, Uzun S, Kozumplik O, Pivac N
Int J Mol Sci 2017 Mar 30;18(4) doi: 10.3390/ijms18040733. PMID: 28358316Free PMC Article

Recent systematic reviews

Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
Hailes HP, Yu R, Danese A, Fazel S
Lancet Psychiatry 2019 Oct;6(10):830-839. Epub 2019 Sep 10 doi: 10.1016/S2215-0366(19)30286-X. PMID: 31519507Free PMC Article
Geretsegger M, Mössler KA, Bieleninik Ł, Chen XJ, Heldal TO, Gold C
Cochrane Database Syst Rev 2017 May 29;5(5):CD004025. doi: 10.1002/14651858.CD004025.pub4. PMID: 28553702Free PMC Article
Fazel S, Gulati G, Linsell L, Geddes JR, Grann M
PLoS Med 2009 Aug;6(8):e1000120. Epub 2009 Aug 11 doi: 10.1371/journal.pmed.1000120. PMID: 19668362Free PMC Article

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