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Chondrosarcoma, Grade 2

MedGen UID:
824797
•Concept ID:
C3838951
•
Neoplastic Process
Synonyms: Chondrosarcoma, grade 2; Grade II Chondrosarcoma; Intermediate Grade Chondrosarcoma; Intermediate-Grade Chondrosarcoma
SNOMED CT: Chondrosarcoma, grade 2 (703699000)

Definition

An intermediate-grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma. It is characterized by the presence of increased cellularity and a greater degree of nuclear atypia and hyperchromasia as compared to grade 1 chondrosarcoma. Mitotic activity is present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondrosarcoma, Grade 2

Professional guidelines

PubMed

Pelvic chondrosarcomas: surgical treatment options.
Deloin X, Dumaine V, Biau D, Karoubi M, Babinet A, Tomeno B, Anract P
Orthop Traumatol Surg Res 2009 Oct;95(6):393-401. Epub 2009 Oct 3 doi: 10.1016/j.otsr.2009.05.004. PMID: 19801212

Recent clinical studies

Diagnosis

An innovative reconstruction of an enbloc resected composite giant chest and abdominal wall chondrosarcoma with 3D-composite mesh.
Dantis K, Singh R, Goel A, Garg B
J Cardiothorac Surg 2024 Mar 14;19(1):126. doi: 10.1186/s13019-024-02595-0. PMID: 38486207Free PMC Article
Cytopathology of Chondromyxoid Fibroma: Report of 2 Cases with Immunocytochemical Expression of GRM1.
Watabe S, Kikuchi Y, Motoi T, Yamamoto A, Imanishi J, Tokizaki T, Sato K, Mukaiyama J, Minami S, Ishida T, Kawano H, Uozaki H
Acta Cytol 2024;68(1):66-72. Epub 2024 Jan 27 doi: 10.1159/000536459. PMID: 38281480
The role of Thallium-201 scintigraphy and Tc-99m pentavalent dimercaptosuccinic acid in diagnosis and grading of chondrosarcoma.
Jo O, Schlicht S, Slavin J, Di Bella C, Pang G, Powell G, Spelman T, Choong PF
Eur J Radiol 2020 Apr;125:108846. Epub 2020 Jan 23 doi: 10.1016/j.ejrad.2020.108846. PMID: 32062570

Therapy

Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H
Cancer Med 2018 May;7(5):1944-1954. Epub 2018 Mar 23 doi: 10.1002/cam4.1438. PMID: 29573200Free PMC Article

Clinical prediction guides

Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H
Cancer Med 2018 May;7(5):1944-1954. Epub 2018 Mar 23 doi: 10.1002/cam4.1438. PMID: 29573200Free PMC Article

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