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Squamous carcinoma in situ

MedGen UID:
83116
•Concept ID:
C0334245
•
Neoplastic Process
Synonyms: carcinoma, squamous cell, in situ, malignant; Epidermoid carcinoma in situ; Epidermoid Carcinoma in situ; epidermoid carcinoma in situ; Epidermoid Cell Carcinoma in situ; epidermoid cell carcinoma in situ; grade 3 SIN; Grade 3 Squamous Intraepithelial Neoplasia; grade 3 squamous intraepithelial neoplasia; grade III SIN; Grade III Squamous Intraepithelial Neoplasia; grade III squamous intraepithelial neoplasia; High grade squamous intraepithelial lesion; IEC - intraepidermal carcinoma; Intraepidermal carcinoma; Intraepithelial squamous cell carcinoma; Intraepithelial Squamous Cell Carcinoma; intraepithelial squamous cell carcinoma; SCC in situ; Squamous Carcinoma in situ; squamous carcinoma in situ; Squamous cell carcinoma in situ; Squamous Cell Carcinoma in situ; squamous cell carcinoma in situ; Squamous Cell Carcinoma in-situ; squamous cell carcinoma in-situ; Squamous intraepithelial neoplasia, grade III; Squamous intraepithelial neoplasia, high grade; Stage 0 Squamous Cell Carcinoma; stage 0 squamous cell carcinoma
SNOMED CT: Intraepithelial squamous cell carcinoma (400066006); Squamous intraepithelial neoplasia, grade III (20365006); Squamous cell carcinoma in situ (189565007); Squamous intraepithelial neoplasia, high grade (20365006); High grade squamous intraepithelial lesion (20365006); Epidermoid carcinoma in situ (1162893000); Intraepidermal carcinoma (1162893000); Intraepithelial squamous cell carcinoma (1162893000); IEC - intraepidermal carcinoma (1162893000); Squamous cell carcinoma in situ (1162893000)
 
Monarch Initiative: MONDO:0004693

Definition

A malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues. [from NCI]

Professional guidelines

PubMed

Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease.
Bir F, Aksoy Altınboga A, Satiroglu Tufan NL, Kaya S, Baser S, Yaren A
Med Sci Monit 2014 Feb 9;20:219-26. doi: 10.12659/MSM.890394. PMID: 24509874Free PMC Article
Atypical squamous cells of undetermined significance in women over 55. Comparison with the general population and implications for management.
Rader AE, Rose PG, Rodriguez M, Mansbacher S, Pitlik D, Abdul-Karim FW
Acta Cytol 1999 May-Jun;43(3):357-62. doi: 10.1159/000331081. PMID: 10349362
Cervical and vaginal cancer detection at a regional diethylstilbestrol (DES) screening clinic.
Piver MS, Lele SB, Baker TR, Sandecki A
Cancer Detect Prev 1988;11(3-6):197-202. PMID: 3390844

Recent clinical studies

Etiology

Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects.
Jonsson S, Franklin WA, Varella-Garcia M, Kennedy TC, Merrick D, Matney KD, Oskarsdottir GN, Saemundsson A, Keith RL, Bunn PA, Miller YE
APMIS 2023 Oct;131(10):513-527. Epub 2023 Aug 23 doi: 10.1111/apm.13345. PMID: 37608782
Conservative Treatment for Patients with Carcinoma in Situ-Positive Margins After a Loop Electroexcisional Procedure: Is It Safe?
Chong GO, Lee YH, Lee YS, Cho YL, Park JY, Hong DG
J Reprod Med 2017 Jan-Feb;62(1-2):37-44. PMID: 29999280
Squamous precursor lesions of the vulva: current classification and diagnostic challenges.
Hoang LN, Park KJ, Soslow RA, Murali R
Pathology 2016 Jun;48(4):291-302. Epub 2016 Apr 23 doi: 10.1016/j.pathol.2016.02.015. PMID: 27113549Free PMC Article
Distal urethrectomy for localized penile squamous carcinoma in situ extending into the urethra: an updated series.
Pedrosa JA, Amstutz SP, Bihrle R, Mellon MJ
Int Urol Nephrol 2014 Aug;46(8):1551-5. Epub 2014 Mar 15 doi: 10.1007/s11255-014-0678-1. PMID: 24633698
Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery.
Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R
J Am Acad Dermatol 2005 Jun;52(6):997-1002. doi: 10.1016/j.jaad.2004.12.033. PMID: 15928618

Diagnosis

Squamous precursor lesions of the vulva: current classification and diagnostic challenges.
Hoang LN, Park KJ, Soslow RA, Murali R
Pathology 2016 Jun;48(4):291-302. Epub 2016 Apr 23 doi: 10.1016/j.pathol.2016.02.015. PMID: 27113549Free PMC Article
Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease.
Bir F, Aksoy Altınboga A, Satiroglu Tufan NL, Kaya S, Baser S, Yaren A
Med Sci Monit 2014 Feb 9;20:219-26. doi: 10.12659/MSM.890394. PMID: 24509874Free PMC Article
Squamous cell carcinoma in situ of the breast: a light microscopic and immunohistochemical study of a previously undescribed lesion.
Hayes MM, Peterse JL, Yavuz E, Vischer GH, Eusebi V
Am J Surg Pathol 2007 Sep;31(9):1414-9. doi: 10.1097/PAS.0b013e31803d15dd. PMID: 17721198
Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery.
Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R
J Am Acad Dermatol 2005 Jun;52(6):997-1002. doi: 10.1016/j.jaad.2004.12.033. PMID: 15928618
Cytologic problems in diagnosis of endocervical atypia in young females with and without maternal history of diethylstilbestrol exposure.
Chenoweth B, Rodney MB
J Natl Med Assoc 1978 Dec;70(12):925-30. PMID: 731720Free PMC Article

Therapy

Synchronous occurrence of hereditary gastric adenocarcinoma, gastrointestinal stromal tumor, and esophageal small cell and squamous carcinoma in situ: an extremely rare case report.
Fan H, Lu P, Xu L, Qin Y, Li J
BMC Cancer 2017 Nov 7;17(1):720. doi: 10.1186/s12885-017-3736-0. PMID: 29115925Free PMC Article
Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey.
He Z, Zhao Y, Guo C, Liu Y, Sun M, Liu F, Wang X, Guo F, Chen K, Gao L, Ning T, Pan Y, Li Y, Zhang S, Lu C, Wang Z, Cai H, Ke Y
Br J Cancer 2010 Sep 28;103(7):1085-8. Epub 2010 Aug 10 doi: 10.1038/sj.bjc.6605843. PMID: 20700119Free PMC Article
Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery.
Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R
J Am Acad Dermatol 2005 Jun;52(6):997-1002. doi: 10.1016/j.jaad.2004.12.033. PMID: 15928618
Progression of squamous carcinoma in situ of the vulva to invasive carcinoma after systemic bleomycin therapy.
Ostor AG, Sfameni SF, Kneale BL, Fortune DW
Aust N Z J Obstet Gynaecol 1984 Feb;24(1):55-8. doi: 10.1111/j.1479-828x.1984.tb03324.x. PMID: 6204633
Cytologic problems in diagnosis of endocervical atypia in young females with and without maternal history of diethylstilbestrol exposure.
Chenoweth B, Rodney MB
J Natl Med Assoc 1978 Dec;70(12):925-30. PMID: 731720Free PMC Article

Prognosis

Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease.
Bir F, Aksoy Altınboga A, Satiroglu Tufan NL, Kaya S, Baser S, Yaren A
Med Sci Monit 2014 Feb 9;20:219-26. doi: 10.12659/MSM.890394. PMID: 24509874Free PMC Article
Utility of conization with frozen section for intraoperative triage prior to definitive hysterectomy.
Martinelli F, Schmeler KM, Johnson C, Brown J, Euscher ED, Ramirez PT, Frumovitz M
Gynecol Oncol 2012 Nov;127(2):307-11. Epub 2012 Jul 26 doi: 10.1016/j.ygyno.2012.07.101. PMID: 22842126Free PMC Article
Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions.
Cooper WA, Kohonen-Corish MR, Zhuang L, McCaughan B, Kennedy C, Screaton G, Sutherland RL, Lee CS
Cancer 2008 Jul 1;113(1):135-42. doi: 10.1002/cncr.23528. PMID: 18457325
Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival.
Sherman ME, Wang SS, Carreon J, Devesa SS
Cancer 2005 Mar 15;103(6):1258-64. doi: 10.1002/cncr.20877. PMID: 15693030
Outcome of carcinoma in situ and early invasive carcinoma of the bronchus.
Mason MK, Jordan JW
Thorax 1982 Jun;37(6):453-6. doi: 10.1136/thx.37.6.453. PMID: 7135280Free PMC Article

Clinical prediction guides

Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects.
Jonsson S, Franklin WA, Varella-Garcia M, Kennedy TC, Merrick D, Matney KD, Oskarsdottir GN, Saemundsson A, Keith RL, Bunn PA, Miller YE
APMIS 2023 Oct;131(10):513-527. Epub 2023 Aug 23 doi: 10.1111/apm.13345. PMID: 37608782
Conservative Treatment for Patients with Carcinoma in Situ-Positive Margins After a Loop Electroexcisional Procedure: Is It Safe?
Chong GO, Lee YH, Lee YS, Cho YL, Park JY, Hong DG
J Reprod Med 2017 Jan-Feb;62(1-2):37-44. PMID: 29999280
Utility of conization with frozen section for intraoperative triage prior to definitive hysterectomy.
Martinelli F, Schmeler KM, Johnson C, Brown J, Euscher ED, Ramirez PT, Frumovitz M
Gynecol Oncol 2012 Nov;127(2):307-11. Epub 2012 Jul 26 doi: 10.1016/j.ygyno.2012.07.101. PMID: 22842126Free PMC Article
Cellular localization of thrombomodulin in human epithelium and squamous malignancies.
Lager DJ, Callaghan EJ, Worth SF, Raife TJ, Lentz SR
Am J Pathol 1995 Apr;146(4):933-43. PMID: 7717460Free PMC Article
The reliability of a cytological prediction of cervical adenocarcinoma in situ.
Laverty CR, Farnsworth A, Thurloe J, Bowditch R
Aust N Z J Obstet Gynaecol 1988 Nov;28(4):307-12. doi: 10.1111/j.1479-828x.1988.tb01688.x. PMID: 3250449

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