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Ductal breast carcinoma in situ and lobular carcinoma in situ

MedGen UID:
83137
•Concept ID:
C0334383
•
Neoplastic Process
Synonyms: Breast Ductal Carcinoma In Situ and Lobular Carcinoma In Situ; DCIS and LCIS of Breast; DCIS and LCIS of breast; DCIS and LCIS of the Breast; DCIS and LCIS of the breast; Ductal and Lobular Breast Carcinoma in situ; ductal and lobular breast carcinoma in situ; Ductal and Lobular Carcinoma in situ of Breast; ductal and lobular carcinoma in situ of breast; Ductal and Lobular Carcinoma in situ of the Breast; ductal and lobular carcinoma in situ of the breast; Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ; ductal breast carcinoma in situ and lobular carcinoma in situ; Ductal Carcinoma in situ with Lobular Carcinoma in situ of Breast; ductal carcinoma in situ with lobular carcinoma in situ of breast; Ductal Carcinoma in situ with Lobular Carcinoma in situ of the Breast; ductal carcinoma in situ with lobular carcinoma in situ of the breast; Intraductal and Lobular Breast Carcinoma in situ; intraductal and lobular breast carcinoma in situ; Intraductal and Lobular Carcinoma in situ of Breast; intraductal and lobular carcinoma in situ of breast; Intraductal and Lobular Carcinoma in situ of the Breast; intraductal and lobular carcinoma in situ of the breast; Intraductal carcinoma and lobular carcinoma in situ; Intraductal Carcinoma and Lobular Carcinoma in situ; intraductal carcinoma and lobular carcinoma in situ; Non-Infiltrating Ductal and Non-Infiltrating Lobular Breast Carcinoma; non-infiltrating ductal and non-infiltrating lobular breast carcinoma; Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of Breast; non-infiltrating ductal with non-infiltrating lobular carcinoma of breast; Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of the Breast; non-infiltrating ductal with non-infiltrating lobular carcinoma of the breast; Non-Invasive Ductal and Non-Invasive Lobular Breast Carcinoma; non-invasive ductal and non-invasive lobular breast carcinoma; Non-Invasive Ductal and Non-Invasive Lobular Carcinoma; non-invasive ductal and non-invasive lobular carcinoma; Non-Invasive Ductal Breast Carcinoma with Non-Invasive Lobular Breast Carcinoma; non-invasive ductal breast carcinoma with non-invasive lobular breast carcinoma; Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of Breast; non-invasive ductal carcinoma with non-invasive lobular carcinoma of breast; Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of the Breast; non-invasive ductal carcinoma with non-invasive lobular carcinoma of the breast; Non-Invasive Ductal with Non-Invasive Lobular Breast Carcinoma; non-invasive ductal with non-invasive lobular breast carcinoma
SNOMED CT: Intraductal carcinoma and lobular carcinoma in situ (18680006)
 
Monarch Initiative: MONDO:0006184

Definition

The co-existence of ductal and lobular carcinoma in situ in the breast, without evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDuctal breast carcinoma in situ and lobular carcinoma in situ

Professional guidelines

PubMed

Management of in situ carcinoma of the breast: lobular and ductal origin.
White RE, Bland KI
R I Med 1995 Sep;78(9):242-5. PMID: 7579718
In situ carcinomas of the female breast. Incidence, clinical findings and DBCG proposals for management.
Graversen HP, Blichert-Toft M, Dyreborg U, Andersen J
Acta Oncol 1988;27(6A):679-82. doi: 10.3109/02841868809091768. PMID: 2851303

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Ductal carcinoma in situ: to treat or not to treat, that is the question.
van Seijen M, Lips EH, Thompson AM, Nik-Zainal S, Futreal A, Hwang ES, Verschuur E, Lane J, Jonkers J, Rea DW, Wesseling J; PRECISION team
Br J Cancer 2019 Aug;121(4):285-292. Epub 2019 Jul 9 doi: 10.1038/s41416-019-0478-6. PMID: 31285590Free PMC Article
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758

Diagnosis

Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article
Ductal carcinoma in situ: to treat or not to treat, that is the question.
van Seijen M, Lips EH, Thompson AM, Nik-Zainal S, Futreal A, Hwang ES, Verschuur E, Lane J, Jonkers J, Rea DW, Wesseling J; PRECISION team
Br J Cancer 2019 Aug;121(4):285-292. Epub 2019 Jul 9 doi: 10.1038/s41416-019-0478-6. PMID: 31285590Free PMC Article

Therapy

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Prognosis

Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758

Clinical prediction guides

Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ.
Tokura M, Nakayama J, Prieto-Vila M, Shiino S, Yoshida M, Yamamoto T, Watanabe N, Takayama S, Suzuki Y, Okamoto K, Ochiya T, Kohno T, Yatabe Y, Suto A, Yamamoto Y
Cancer Res 2022 Sep 16;82(18):3236-3248. doi: 10.1158/0008-5472.CAN-22-0090. PMID: 35852797
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758

Recent systematic reviews

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.
Bundred JR, Michael S, Stuart B, Cutress RI, Beckmann K, Holleczek B, Dahlstrom JE, Gath J, Dodwell D, Bundred NJ
BMJ 2022 Sep 21;378:e070346. doi: 10.1136/bmj-2022-070346. PMID: 36130770Free PMC Article
Patient-reported outcomes in ductal carcinoma in situ: A systematic review.
King MT, Winters ZE, Olivotto IA, Spillane AJ, Chua BH, Saunders C, Westenberg AH, Mann GB, Burnett P, Butow P, Rutherford C
Eur J Cancer 2017 Jan;71:95-108. Epub 2016 Dec 15 doi: 10.1016/j.ejca.2016.09.035. PMID: 27987454
Benefits and Harms of Breast Cancer Screening: A Systematic Review.
Myers ER, Moorman P, Gierisch JM, Havrilesky LJ, Grimm LJ, Ghate S, Davidson B, Mongtomery RC, Crowley MJ, McCrory DC, Kendrick A, Sanders GD
JAMA 2015 Oct 20;314(15):1615-34. doi: 10.1001/jama.2015.13183. PMID: 26501537

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