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Invasive Breast Ductal Carcinoma and Lobular Carcinoma In Situ

MedGen UID:
83138
•Concept ID:
C0334384
•
Neoplastic Process
Synonyms: Infiltrating duct and lobular carcinoma; Infiltrating duct and lobular carcinoma in situ; Infiltrating Ductal and Lobular Carcinoma in situ; Infiltrating lobular carcinoma and ductal carcinoma in situ; Intraductal and lobular carcinoma; Invasive Ductal and Lobular Carcinoma In Situ; LCIS and Infiltrating Ductal Carcinoma; Lobular and ductal carcinoma; Lobular Carcinoma in situ and Infiltrating Ductal Carcinoma; Lobular Carcinoma in situ and Invasive Ductal Carcinoma
SNOMED CT: Infiltrating lobular carcinoma and ductal carcinoma in situ (35232005); Infiltrating duct and lobular carcinoma (35232005); Infiltrating duct and lobular carcinoma in situ (35232005); Lobular and ductal carcinoma (35232005); Intraductal and lobular carcinoma (35232005)

Definition

An invasive ductal breast carcinoma associated with an in situ lobular carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Breast Ductal Carcinoma and Lobular Carcinoma In Situ

Professional guidelines

PubMed

Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673
Breast Cancer Treatment.
Trayes KP, Cokenakes SEH
Am Fam Physician 2021 Aug 1;104(2):171-178. PMID: 34383430
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Epidemiology of Ductal Carcinoma In Situ.
Iatrakis G, Zervoudis S
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S15-S21. doi: 10.21614/chirurgia.116.5.suppl.S15. PMID: 34967307
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Interobserver Variability in Ductal Carcinoma In Situ of the Breast.
Van Bockstal MR, Berlière M, Duhoux FP, Galant C
Am J Clin Pathol 2020 Oct 13;154(5):596-609. doi: 10.1093/ajcp/aqaa077. PMID: 32566938
Duct carcinoma in situ: A personal perspective.
Lagios MD
Breast J 2020 Jun;26(6):1132-1137. Epub 2020 May 10 doi: 10.1111/tbj.13860. PMID: 32390260

Diagnosis

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Ductal Carcinoma In Situ. Interventional Diagnosis.
Lisencu C, Lesaru M
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S50-S58. doi: 10.21614/chirurgia.116.5.suppl.S50. PMID: 34967311
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article

Therapy

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening.
Comstock CE, Gatsonis C, Newstead GM, Snyder BS, Gareen IF, Bergin JT, Rahbar H, Sung JS, Jacobs C, Harvey JA, Nicholson MH, Ward RC, Holt J, Prather A, Miller KD, Schnall MD, Kuhl CK
JAMA 2020 Feb 25;323(8):746-756. doi: 10.1001/jama.2020.0572. PMID: 32096852Free PMC Article
Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial.
Cuzick J, Sestak I, Forbes JF, Dowsett M, Cawthorn S, Mansel RE, Loibl S, Bonanni B, Evans DG, Howell A; IBIS-II investigators
Lancet 2020 Jan 11;395(10218):117-122. Epub 2019 Dec 12 doi: 10.1016/S0140-6736(19)32955-1. PMID: 31839281Free PMC Article
Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement.
Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J, Harris JR
Pract Radiat Oncol 2017 Mar-Apr;7(2):73-79. Epub 2016 Sep 17 doi: 10.1016/j.prro.2016.09.007. PMID: 27866865
Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.
von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, Gerber B, Eiermann W, Hilfrich J, Huober J, Jackisch C, Kaufmann M, Konecny GE, Denkert C, Nekljudova V, Mehta K, Loibl S
J Clin Oncol 2012 May 20;30(15):1796-804. Epub 2012 Apr 16 doi: 10.1200/JCO.2011.38.8595. PMID: 22508812

Prognosis

The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article

Clinical prediction guides

Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.
Strand SH, Rivero-Gutiérrez B, Houlahan KE, Seoane JA, King LM, Risom T, Simpson LA, Vennam S, Khan A, Cisneros L, Hardman T, Harmon B, Couch F, Gallagher K, Kilgore M, Wei S, DeMichele A, King T, McAuliffe PF, Nangia J, Lee J, Tseng J, Storniolo AM, Thompson AM, Gupta GP, Burns R, Veis DJ, DeSchryver K, Zhu C, Matusiak M, Wang J, Zhu SX, Tappenden J, Ding DY, Zhang D, Luo J, Jiang S, Varma S, Anderson L, Straub C, Srivastava S, Curtis C, Tibshirani R, Angelo RM, Hall A, Owzar K, Polyak K, Maley C, Marks JR, Colditz GA, Hwang ES, West RB
Cancer Cell 2022 Dec 12;40(12):1521-1536.e7. Epub 2022 Nov 17 doi: 10.1016/j.ccell.2022.10.021. PMID: 36400020Free PMC Article
Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ.
Tokura M, Nakayama J, Prieto-Vila M, Shiino S, Yoshida M, Yamamoto T, Watanabe N, Takayama S, Suzuki Y, Okamoto K, Ochiya T, Kohno T, Yatabe Y, Suto A, Yamamoto Y
Cancer Res 2022 Sep 16;82(18):3236-3248. doi: 10.1158/0008-5472.CAN-22-0090. PMID: 35852797
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Interobserver Variability in Ductal Carcinoma In Situ of the Breast.
Van Bockstal MR, Berlière M, Duhoux FP, Galant C
Am J Clin Pathol 2020 Oct 13;154(5):596-609. doi: 10.1093/ajcp/aqaa077. PMID: 32566938
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Recent systematic reviews

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.
Bundred JR, Michael S, Stuart B, Cutress RI, Beckmann K, Holleczek B, Dahlstrom JE, Gath J, Dodwell D, Bundred NJ
BMJ 2022 Sep 21;378:e070346. doi: 10.1136/bmj-2022-070346. PMID: 36130770Free PMC Article
Patient-reported outcomes in ductal carcinoma in situ: A systematic review.
King MT, Winters ZE, Olivotto IA, Spillane AJ, Chua BH, Saunders C, Westenberg AH, Mann GB, Burnett P, Butow P, Rutherford C
Eur J Cancer 2017 Jan;71:95-108. Epub 2016 Dec 15 doi: 10.1016/j.ejca.2016.09.035. PMID: 27987454
Post-operative radiotherapy for ductal carcinoma in situ of the breast.
Goodwin A, Parker S, Ghersi D, Wilcken N
Cochrane Database Syst Rev 2013 Nov 21;(11):CD000563. doi: 10.1002/14651858.CD000563.pub7. PMID: 24259251

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