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Type A Spindle Cell Melanoma

MedGen UID:
83148
•Concept ID:
C0334445
•
Neoplastic Process
Synonyms: Malignant Spindle Cell Type A Melanoma; Spindle cell melanoma - type A; Spindle cell melanoma, type A; Spindle Cell Type A Malignant Melanoma
SNOMED CT: Spindle cell melanoma - type A (24653009); Spindle cell melanoma, type A (24653009)

Definition

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. Representative example is the type A spindle cell uveal melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType A Spindle Cell Melanoma

Professional guidelines

PubMed

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Recent clinical studies

Etiology

Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.
Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164
Spindle cell melanoma: a comparison of the cytomorphological features with the epithelioid variant.
Walia R, Jain D, Mathur SR, Iyer VK
Acta Cytol 2013;57(6):557-61. Epub 2013 Oct 1 doi: 10.1159/000354405. PMID: 24107480
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Diagnosis

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Animal-type melanoma - tumor cell invasion of dermal lymphatics and molecular identification of lymph node metastasis.
Posch C, Vesely M, Monshi B, Feichtinger H, Cziegler K, Rappersberger K
J Dtsch Dermatol Ges 2012 Jan;10(1):38-41. Epub 2011 May 3 doi: 10.1111/j.1610-0387.2011.07688.x. PMID: 21539708
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Therapy

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309

Prognosis

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype.
Longhitano L, Giallongo S, Orlando L, Broggi G, Longo A, Russo A, Caltabiano R, Giallongo C, Barbagallo I, Di Rosa M, Giuffrida R, Parenti R, Li Volti G, Vicario N, Tibullo D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010024. PMID: 36613471Free PMC Article
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164
Animal-type melanoma - tumor cell invasion of dermal lymphatics and molecular identification of lymph node metastasis.
Posch C, Vesely M, Monshi B, Feichtinger H, Cziegler K, Rappersberger K
J Dtsch Dermatol Ges 2012 Jan;10(1):38-41. Epub 2011 May 3 doi: 10.1111/j.1610-0387.2011.07688.x. PMID: 21539708
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539

Clinical prediction guides

Perineural differentiation in neurotized nevi.
Leblebici C, Mod BN, Cin M, Özcan B
Pathol Res Pract 2024 Mar;255:155184. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155184. PMID: 38324967
Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
Clinicopathologic and Dermoscopic Features of 20 Cases of Spark's Nevus, a Dermoscopic Simulator of Melanoma.
Massone C, Stanganelli I, Ingordo V, Ferrara G, Brunasso AMG, Siri G, Casazza S, Gnone M, Pizzichetta MA, Giovanni B, Chiodi S, Sola S
Am J Dermatopathol 2023 Mar 1;45(3):153-162. Epub 2022 Nov 7 doi: 10.1097/DAD.0000000000002323. PMID: 36730758
Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.
Tardío JC, Pinedo F, Aramburu JA, Martínez-González MÁ, Arias D, Khedaoui R, Suárez-Massa D, Santonja C
Am J Dermatopathol 2016 Aug;38(8):586-92. doi: 10.1097/DAD.0000000000000465. PMID: 26848640
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539

Recent systematic reviews

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

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