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Diabetic neuropathy

MedGen UID:
8353
Concept ID:
C0011882
Disease or Syndrome
Synonyms: Diabetic Neuropathies; Diabetic Neuropathy; Neuropathies, Diabetic; Neuropathy, Diabetic
SNOMED CT: Diabetic neuropathy (230572002); Diabetes mellitus with neuropathy (230572002); Neuropathy due to diabetes mellitus (230572002)
 
Monarch Initiative: MONDO:0006626

Definition

A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Adams D, Ando Y, Beirão JM, Coelho T, Gertz MA, Gillmore JD, Hawkins PN, Lousada I, Suhr OB, Merlini G
J Neurol 2021 Jun;268(6):2109-2122. Epub 2020 Jan 6 doi: 10.1007/s00415-019-09688-0. PMID: 31907599Free PMC Article
Bandyk DF
Semin Vasc Surg 2018 Jun-Dec;31(2-4):43-48. Epub 2019 Feb 6 doi: 10.1053/j.semvascsurg.2019.02.001. PMID: 30876640

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):41. doi: 10.1038/s41572-019-0092-1. PMID: 31197153
Papanas N, Ziegler D
Expert Opin Pharmacother 2014 Dec;15(18):2721-31. Epub 2014 Nov 10 doi: 10.1517/14656566.2014.972935. PMID: 25381809
Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic Neuropathy Expert Group
Diabetes Care 2010 Oct;33(10):2285-93. doi: 10.2337/dc10-1303. PMID: 20876709Free PMC Article

Diagnosis

Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Rosenberger DC, Blechschmidt V, Timmerman H, Wolff A, Treede RD
J Neural Transm (Vienna) 2020 Apr;127(4):589-624. Epub 2020 Feb 8 doi: 10.1007/s00702-020-02145-7. PMID: 32036431Free PMC Article
Zakin E, Abrams R, Simpson DM
Semin Neurol 2019 Oct;39(5):560-569. Epub 2019 Oct 22 doi: 10.1055/s-0039-1688978. PMID: 31639839
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Vinik AI, Nevoret ML, Casellini C, Parson H
Endocrinol Metab Clin North Am 2013 Dec;42(4):747-87. doi: 10.1016/j.ecl.2013.06.001. PMID: 24286949

Therapy

Gwathmey KG, Pearson KT
BMJ 2019 May 8;365:l1108. doi: 10.1136/bmj.l1108. PMID: 31068323
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA
Cochrane Database Syst Rev 2017 Jun 9;6(6):CD007938. doi: 10.1002/14651858.CD007938.pub4. PMID: 28597471Free PMC Article
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article
Papanas N, Ziegler D
Expert Opin Pharmacother 2014 Dec;15(18):2721-31. Epub 2014 Nov 10 doi: 10.1517/14656566.2014.972935. PMID: 25381809

Prognosis

Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Schneider C, Stratman S, Kirsner RS
Med Clin North Am 2021 Jul;105(4):663-679. doi: 10.1016/j.mcna.2021.04.006. PMID: 34059244
Jensen TS, Karlsson P, Gylfadottir SS, Andersen ST, Bennett DL, Tankisi H, Finnerup NB, Terkelsen AJ, Khan K, Themistocleous AC, Kristensen AG, Itani M, Sindrup SH, Andersen H, Charles M, Feldman EL, Callaghan BC
Brain 2021 Jul 28;144(6):1632-1645. doi: 10.1093/brain/awab079. PMID: 33711103Free PMC Article
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963

Clinical prediction guides

Saini DC, Kochar A, Poonia R
Indian J Ophthalmol 2021 Nov;69(11):3364-3368. doi: 10.4103/ijo.IJO_1237_21. PMID: 34708806Free PMC Article
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K
Nutrients 2021 Jan 27;13(2) doi: 10.3390/nu13020395. PMID: 33513879Free PMC Article
Bandyk DF
Semin Vasc Surg 2018 Jun-Dec;31(2-4):43-48. Epub 2019 Feb 6 doi: 10.1053/j.semvascsurg.2019.02.001. PMID: 30876640
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Brocco E, Ninkovic S, Marin M, Whisstock C, Bruseghin M, Boschetti G, Viti R, Forlini W, Volpe A
J Cardiovasc Surg (Torino) 2018 Oct;59(5):670-684. Epub 2018 May 29 doi: 10.23736/S0021-9509.18.10606-9. PMID: 29808982

Recent systematic reviews

D'Souza RS, Barman R, Joseph A, Abd-Elsayed A
Curr Pain Headache Rep 2022 Aug;26(8):583-594. Epub 2022 Jun 18 doi: 10.1007/s11916-022-01061-7. PMID: 35716275
Hernández-Secorún M, Montaña-Cortés R, Hidalgo-García C, Rodríguez-Sanz J, Corral-de-Toro J, Monti-Ballano S, Hamam-Alcober S, Tricás-Moreno JM, Lucha-López MO
Int J Environ Res Public Health 2021 Feb 28;18(5) doi: 10.3390/ijerph18052365. PMID: 33671060Free PMC Article
Collings R, Freeman J, Latour JM, Paton J
Endocrinol Diabetes Metab 2021 Jan;4(1):e00132. Epub 2020 Apr 11 doi: 10.1002/edm2.132. PMID: 33532602Free PMC Article
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

    Consumer resources

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