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Metastatic Malignant Neoplasm in the Nervous System

MedGen UID:
83846
Concept ID:
C0347014
Neoplastic Process
Synonyms: Cancer metastatic to nervous system; Metastases to Nervous System; Metastasis to nervous system; Metastasis to the Nervous System; Metastatic malignant neoplasm of nervous system; Metastatic malignant neoplasm to nervous system; Metastatic Malignant Neoplasm to the Nervous System; Metastatic Neoplasm to the Nervous System; Metastatic Tumor to the Nervous System; Secondary malignant neoplasm of nervous system; Secondary Malignant Neoplasm to the Nervous System; Secondary Malignant Tumor to the Nervous System
SNOMED CT: Metastasis to nervous system (94442001); Secondary malignant neoplasm of nervous system (94442001); Metastatic malignant neoplasm to nervous system (94442001); Cancer metastatic to nervous system (94442001); Metastatic malignant neoplasm of nervous system (94442001)

Definition

The spread of a malignant neoplasm to the nervous system. This may be from a primary nervous system malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Professional guidelines

PubMed

Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
Swift CC, Eklund MJ, Kraveka JM, Alazraki AL
Radiographics 2018 Mar-Apr;38(2):566-580. doi: 10.1148/rg.2018170132. PMID: 29528815

Recent clinical studies

Etiology

Popat S, Ahn MJ, Ekman S, Leighl NB, Ramalingam SS, Reungwetwattana T, Siva S, Tsuboi M, Wu YL, Yang JC
Target Oncol 2023 Jan;18(1):9-24. Epub 2023 Jan 18 doi: 10.1007/s11523-022-00941-7. PMID: 36652172
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Gu W, Rauschecker AM, Hsu E, Zorn KC, Sucu Y, Federman S, Gopez A, Arevalo S, Sample HA, Talevich E, Nguyen ED, Gottschall M, Nourbakhsh B, Gold CA, Cree BAC, Douglas VC, Richie MB, Shah MP, Josephson SA, Gelfand JM, Miller S, Wang L, Tihan T, DeRisi JL, Chiu CY, Wilson MR
JAMA Neurol 2021 Nov 1;78(11):1355-1366. doi: 10.1001/jamaneurol.2021.3088. PMID: 34515766Free PMC Article
Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS
Neuro Oncol 2021 Jul 1;23(7):1056-1071. doi: 10.1093/neuonc/noab020. PMID: 33560416Free PMC Article
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

Diagnosis

Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S
J Natl Compr Canc Netw 2023 Jan;21(1):12-20. doi: 10.6004/jnccn.2023.0002. PMID: 36634606
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Gu W, Rauschecker AM, Hsu E, Zorn KC, Sucu Y, Federman S, Gopez A, Arevalo S, Sample HA, Talevich E, Nguyen ED, Gottschall M, Nourbakhsh B, Gold CA, Cree BAC, Douglas VC, Richie MB, Shah MP, Josephson SA, Gelfand JM, Miller S, Wang L, Tihan T, DeRisi JL, Chiu CY, Wilson MR
JAMA Neurol 2021 Nov 1;78(11):1355-1366. doi: 10.1001/jamaneurol.2021.3088. PMID: 34515766Free PMC Article
Nabors LB, Portnow J, Ahluwalia M, Baehring J, Brem H, Brem S, Butowski N, Campian JL, Clark SW, Fabiano AJ, Forsyth P, Hattangadi-Gluth J, Holdhoff M, Horbinski C, Junck L, Kaley T, Kumthekar P, Loeffler JS, Mrugala MM, Nagpal S, Pandey M, Parney I, Peters K, Puduvalli VK, Robins I, Rockhill J, Rusthoven C, Shonka N, Shrieve DC, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow SD
J Natl Compr Canc Netw 2020 Nov 2;18(11):1537-1570. doi: 10.6004/jnccn.2020.0052. PMID: 33152694
Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M
Nat Med 2018 Jul;24(7):1024-1035. Epub 2018 Jun 11 doi: 10.1038/s41591-018-0044-4. PMID: 29892069

Therapy

Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Orellana-Noia V, Abousaud A
Curr Treat Options Oncol 2022 Oct;23(10):1443-1456. Epub 2022 Sep 21 doi: 10.1007/s11864-022-01017-4. PMID: 36127571
Wirth LJ, Brose MS, Elisei R, Capdevila J, Hoff AO, Hu MI, Tahara M, Robinson B, Gao M, Xia M, Maeda P, Sherman E
Future Oncol 2022 Sep;18(28):3143-3150. Epub 2022 Aug 15 doi: 10.2217/fon-2022-0657. PMID: 35969032Free PMC Article
Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS
Neuro Oncol 2021 Jul 1;23(7):1056-1071. doi: 10.1093/neuonc/noab020. PMID: 33560416Free PMC Article
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612

Prognosis

Corti C, Antonarelli G, Criscitiello C, Lin NU, Carey LA, Cortés J, Poortmans P, Curigliano G
Cancer Treat Rev 2022 Feb;103:102324. Epub 2021 Dec 16 doi: 10.1016/j.ctrv.2021.102324. PMID: 34953200
Novello S, Mazières J, Oh IJ, de Castro J, Migliorino MR, Helland Å, Dziadziuszko R, Griesinger F, Kotb A, Zeaiter A, Cardona A, Balas B, Johannsdottir HK, Das-Gupta A, Wolf J
Ann Oncol 2018 Jun 1;29(6):1409-1416. doi: 10.1093/annonc/mdy121. PMID: 29668860Free PMC Article
Larson RA
Leuk Lymphoma 2018 Jan;59(1):3-13. Epub 2017 May 23 doi: 10.1080/10428194.2017.1326597. PMID: 28535095
Sarkar D, Fisher PB
Adv Cancer Res 2013;120:39-74. doi: 10.1016/B978-0-12-401676-7.00002-4. PMID: 23889987Free PMC Article
Shah S, Ravindranath Y
Indian J Pediatr 1998 Sep-Oct;65(5):691-705. doi: 10.1007/BF02731044. PMID: 10773924

Clinical prediction guides

Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Nicolaidis S
Metabolism 2015 Mar;64(3 Suppl 1):S22-7. Epub 2014 Oct 30 doi: 10.1016/j.metabol.2014.10.031. PMID: 25468141
Sarkar D, Fisher PB
Adv Cancer Res 2013;120:39-74. doi: 10.1016/B978-0-12-401676-7.00002-4. PMID: 23889987Free PMC Article
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Liebig C, Ayala G, Wilks JA, Berger DH, Albo D
Cancer 2009 Aug 1;115(15):3379-91. doi: 10.1002/cncr.24396. PMID: 19484787

Recent systematic reviews

Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Gondi V, Bauman G, Bradfield L, Burri SH, Cabrera AR, Cunningham DA, Eaton BR, Hattangadi-Gluth JA, Kim MM, Kotecha R, Kraemer L, Li J, Nagpal S, Rusthoven CG, Suh JH, Tomé WA, Wang TJC, Zimmer AS, Ziu M, Brown PD
Pract Radiat Oncol 2022 Jul-Aug;12(4):265-282. Epub 2022 May 6 doi: 10.1016/j.prro.2022.02.003. PMID: 35534352
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Wang L, Paller CJ, Hong H, De Felice A, Alexander GC, Brawley O
JAMA Oncol 2021 Mar 1;7(3):412-420. doi: 10.1001/jamaoncol.2020.6973. PMID: 33443584Free PMC Article

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