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Peripheral neuropathy due to and following antineoplastic therapy

MedGen UID:
840042
Concept ID:
C3873567
Disease or Syndrome
Synonyms: Chemotherapeutic Drug - Induced Peripheral Neuropathy; Chemotherapy-Induced Peripheral Neuropathy; CIPN - Chemotherapy-induced peripheral neuropathy; Peripheral neuropathy due to and following chemotherapy
SNOMED CT: CIPN - Chemotherapy-induced peripheral neuropathy (767659008); Peripheral neuropathy due to and following chemotherapy (767659008); Peripheral neuropathy due to and following antineoplastic therapy (767659008)

Definition

Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral neuropathy due to and following antineoplastic therapy

Professional guidelines

PubMed

Hou S, Huh B, Kim HK, Kim KH, Abdi S
Pain Physician 2018 Nov;21(6):571-592. PMID: 30508986
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent clinical studies

Etiology

Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, Rosenthal DS, Ligibel JA
Oncologist 2020 Apr;25(4):310-318. Epub 2019 Oct 14 doi: 10.1634/theoncologist.2019-0489. PMID: 32297442Free PMC Article
Colvin LA
Pain 2019 May;160 Suppl 1(Suppl 1):S1-S10. doi: 10.1097/j.pain.0000000000001540. PMID: 31008843Free PMC Article
Hou S, Huh B, Kim HK, Kim KH, Abdi S
Pain Physician 2018 Nov;21(6):571-592. PMID: 30508986
Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, Bressler LR, Fadul CE, Knox C, Le-Lindqwister N, Gilman PB, Shapiro CL; Alliance for Clinical Trials in Oncology
JAMA 2013 Apr 3;309(13):1359-67. doi: 10.1001/jama.2013.2813. PMID: 23549581Free PMC Article
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Marini A, Bernardini A, Gigli GL, Valente M, Muñiz-Castrillo S, Honnorat J, Vogrig A
Neurology 2021 Apr 20;96(16):754-766. Epub 2021 Mar 2 doi: 10.1212/WNL.0000000000011795. PMID: 33653902
Rosiñol L, Oriol A, Rios R, Sureda A, Blanchard MJ, Hernández MT, Martínez-Martínez R, Moraleda JM, Jarque I, Bargay J, Gironella M, de Arriba F, Palomera L, González-Montes Y, Martí JM, Krsnik I, Arguiñano JM, González ME, González AP, Casado LF, López-Anglada L, Paiva B, Mateos MV, San Miguel JF, Lahuerta JJ, Bladé J
Blood 2019 Oct 17;134(16):1337-1345. doi: 10.1182/blood.2019000241. PMID: 31484647Free PMC Article
Colvin LA
Pain 2019 May;160 Suppl 1(Suppl 1):S1-S10. doi: 10.1097/j.pain.0000000000001540. PMID: 31008843Free PMC Article
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article
Fehrenbacher JC
Prog Mol Biol Transl Sci 2015;131:471-508. Epub 2015 Feb 7 doi: 10.1016/bs.pmbts.2014.12.002. PMID: 25744683

Therapy

Klafke N, Bossert J, Kröger B, Neuberger P, Heyder U, Layer M, Winkler M, Idler C, Kaschdailewitsch E, Heine R, John H, Zielke T, Schmeling B, Joy S, Mertens I, Babadag-Savas B, Kohler S, Mahler C, Witt CM, Steinmann D, Voiss P, Stolz R
Med Sci (Basel) 2023 Jan 30;11(1) doi: 10.3390/medsci11010015. PMID: 36810482Free PMC Article
Ibrahim EY, Ehrlich BE
Crit Rev Oncol Hematol 2020 Jan;145:102831. Epub 2019 Nov 13 doi: 10.1016/j.critrevonc.2019.102831. PMID: 31783290Free PMC Article
Colvin LA
Pain 2019 May;160 Suppl 1(Suppl 1):S1-S10. doi: 10.1097/j.pain.0000000000001540. PMID: 31008843Free PMC Article
Hou S, Huh B, Kim HK, Kim KH, Abdi S
Pain Physician 2018 Nov;21(6):571-592. PMID: 30508986
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article

Prognosis

Ansell SM, Radford J, Connors JM, Długosz-Danecka M, Kim WS, Gallamini A, Ramchandren R, Friedberg JW, Advani R, Hutchings M, Evens AM, Smolewski P, Savage KJ, Bartlett NL, Eom HS, Abramson JS, Dong C, Campana F, Fenton K, Puhlmann M, Straus DJ; ECHELON-1 Study Group
N Engl J Med 2022 Jul 28;387(4):310-320. Epub 2022 Jul 13 doi: 10.1056/NEJMoa2206125. PMID: 35830649
Müller J, Weiler M, Schneeweiss A, Haag GM, Steindorf K, Wick W, Wiskemann J
Br J Cancer 2021 Sep;125(7):955-965. Epub 2021 Jul 5 doi: 10.1038/s41416-021-01471-1. PMID: 34226683Free PMC Article
Jordan B, Margulies A, Cardoso F, Cavaletti G, Haugnes HS, Jahn P, Le Rhun E, Preusser M, Scotté F, Taphoorn MJB, Jordan K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EONS Education Working Group. Electronic address: eons.secretariat@cancernurse.eu; EANO Guideline Committee. Electronic address: office@eano.eu
Ann Oncol 2020 Oct;31(10):1306-1319. Epub 2020 Jul 30 doi: 10.1016/j.annonc.2020.07.003. PMID: 32739407
Ibrahim EY, Ehrlich BE
Crit Rev Oncol Hematol 2020 Jan;145:102831. Epub 2019 Nov 13 doi: 10.1016/j.critrevonc.2019.102831. PMID: 31783290Free PMC Article
Tolaney SM, Guo H, Pernas S, Barry WT, Dillon DA, Ritterhouse L, Schneider BP, Shen F, Fuhrman K, Baltay M, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Overmoyer B, Partridge AH, Hudis CA, Krop IE, Burstein HJ, Winer EP
J Clin Oncol 2019 Aug 1;37(22):1868-1875. Epub 2019 Apr 2 doi: 10.1200/JCO.19.00066. PMID: 30939096Free PMC Article

Clinical prediction guides

Ansell SM, Radford J, Connors JM, Długosz-Danecka M, Kim WS, Gallamini A, Ramchandren R, Friedberg JW, Advani R, Hutchings M, Evens AM, Smolewski P, Savage KJ, Bartlett NL, Eom HS, Abramson JS, Dong C, Campana F, Fenton K, Puhlmann M, Straus DJ; ECHELON-1 Study Group
N Engl J Med 2022 Jul 28;387(4):310-320. Epub 2022 Jul 13 doi: 10.1056/NEJMoa2206125. PMID: 35830649
Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, Wyrwicz L, Yamaguchi K, Skoczylas T, Campos Bragagnoli A, Liu T, Schenker M, Yanez P, Tehfe M, Kowalyszyn R, Karamouzis MV, Bruges R, Zander T, Pazo-Cid R, Hitre E, Feeney K, Cleary JM, Poulart V, Cullen D, Lei M, Xiao H, Kondo K, Li M, Ajani JA
Lancet 2021 Jul 3;398(10294):27-40. Epub 2021 Jun 5 doi: 10.1016/S0140-6736(21)00797-2. PMID: 34102137Free PMC Article
Ibrahim EY, Ehrlich BE
Crit Rev Oncol Hematol 2020 Jan;145:102831. Epub 2019 Nov 13 doi: 10.1016/j.critrevonc.2019.102831. PMID: 31783290Free PMC Article
Horwitz S, O'Connor OA, Pro B, Illidge T, Fanale M, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Lennard A, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Iyer S, Zinzani PL, Hua Z, Little M, Rao S, Woolery J, Manley T, Trümper L; ECHELON-2 Study Group
Lancet 2019 Jan 19;393(10168):229-240. Epub 2018 Dec 4 doi: 10.1016/S0140-6736(18)32984-2. PMID: 30522922Free PMC Article
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF
N Engl J Med 2013 Oct 31;369(18):1691-703. Epub 2013 Oct 16 doi: 10.1056/NEJMoa1304369. PMID: 24131140Free PMC Article

Recent systematic reviews

Klafke N, Bossert J, Kröger B, Neuberger P, Heyder U, Layer M, Winkler M, Idler C, Kaschdailewitsch E, Heine R, John H, Zielke T, Schmeling B, Joy S, Mertens I, Babadag-Savas B, Kohler S, Mahler C, Witt CM, Steinmann D, Voiss P, Stolz R
Med Sci (Basel) 2023 Jan 30;11(1) doi: 10.3390/medsci11010015. PMID: 36810482Free PMC Article
Marini A, Bernardini A, Gigli GL, Valente M, Muñiz-Castrillo S, Honnorat J, Vogrig A
Neurology 2021 Apr 20;96(16):754-766. Epub 2021 Mar 2 doi: 10.1212/WNL.0000000000011795. PMID: 33653902
Hou S, Huh B, Kim HK, Kim KH, Abdi S
Pain Physician 2018 Nov;21(6):571-592. PMID: 30508986
Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD010369. doi: 10.1002/14651858.CD010369.pub2. PMID: 28084646Free PMC Article
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article

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