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Bilateral cleft lip and palate

MedGen UID:
853256
•Concept ID:
C1398522
•
Congenital Abnormality
Synonym: Bilateral cleft lip/palate
SNOMED CT: Cleft palate and bilateral cleft lip (1085331000119107); Uranostaphyloschisis with bilateral cleft lip (1085331000119107); Cleft hard and soft palate and bilateral cleft lip (1085331000119107)

Professional guidelines

PubMed

Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.
Hattori Y, Pai BC, Saito T, Chou PY, Lu TC, Chang CS, Chen YR, Lo LJ
Int J Surg 2023 Jun 1;109(6):1656-1667. doi: 10.1097/JS9.0000000000000406. PMID: 37073546Free PMC Article
Primary Palatal Surgery in Nonsyndromic Cleft Palate Children and Velopharyngeal Insufficiency Correction Outcomes.
Carvajal Álvarez DC, Palomares-Aguilera MM, Meneses Geldres MB, Villarroel Giugliano C
J Craniofac Surg 2021 Mar-Apr 01;32(2):698-704. doi: 10.1097/SCS.0000000000007514. PMID: 33705013
Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831

Recent clinical studies

Etiology

Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.
Hattori Y, Pai BC, Saito T, Chou PY, Lu TC, Chang CS, Chen YR, Lo LJ
Int J Surg 2023 Jun 1;109(6):1656-1667. doi: 10.1097/JS9.0000000000000406. PMID: 37073546Free PMC Article
Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic.
Bangun K, Halim J, Tania V
Cleft Palate Craniofac J 2023 May;60(5):621-626. Epub 2021 Dec 30 doi: 10.1177/10556656211069820. PMID: 34967231
Successful Management of Cleft Lip and Palate Malformation without Pre-Surgical Infant Orthopedics.
Schwarz SJ, Brandenburg LS, Weingart JV, Schupp W, Füssinger MA, Stocker SA, Metzger MC
J Clin Pediatr Dent 2021 Jul 1;45(3):204-207. doi: 10.17796/1053-4625-45.3.10. PMID: 34192752
Alveolar bone grafting and gingivoperiosteoplasty in bilateral cleft lip and palate.
Chhajlani R, Chhajlani P, Bonanthaya K, Mahajan RK
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):327-332. doi: 10.1097/MOO.0000000000000737. PMID: 34091502
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613

Diagnosis

Bilateral cleft lip, alveolus, and palate deformity in an infant.
Nimonkar SV, Belkhode VM
Pan Afr Med J 2022;42:316. Epub 2022 Aug 29 doi: 10.11604/pamj.2022.42.316.33040. PMID: 36451981Free PMC Article
Orthodontic-care burden for patients with unilateral and bilateral cleft lip and palate.
Roguzińska S, Pelc A, Mikulewicz M
Dent Med Probl 2020 Oct-Dec;57(4):411-416. doi: 10.17219/dmp/125874. PMID: 33448166
Invasive cervical resorption and the oro-facial cleft patient: a review and case series.
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Indices to assess malocclusions in patients with cleft lip and palate.
Altalibi M, Saltaji H, Edwards R, Major PW, Flores-Mir C
Eur J Orthod 2013 Dec;35(6):772-82. Epub 2013 Mar 15 doi: 10.1093/ejo/cjt009. PMID: 23504529
Acrofacial dysostoses.
Le Merrer M, Cikuli M, Ribier J, Briard ML
Am J Med Genet 1989 Jul;33(3):318-22. doi: 10.1002/ajmg.1320330307. PMID: 2801764

Therapy

Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Bilateral Cleft Lip and Palate, With Facial Dysplasia: Interdisciplinary Treatment and Long-Term Follow-Up.
Bennun RD, Harfin JH
J Craniofac Surg 2018 Sep;29(6):1441-1444. doi: 10.1097/SCS.0000000000004756. PMID: 30015740
Invasive cervical resorption and the oro-facial cleft patient: a review and case series.
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Dental anomalies associated with unilateral and bilateral cleft lip and palate.
Qureshi WA, Beiraghi S, Leon-Salazar V
J Dent Child (Chic) 2012 May-Aug;79(2):69-73. PMID: 22828761
Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate.
Guo J, Li C, Zhang Q, Wu G, Deacon SA, Chen J, Hu H, Zou S, Ye Q
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008050. doi: 10.1002/14651858.CD008050.pub2. PMID: 21678372

Prognosis

Long-term Follow-up of Bilateral Cleft Lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation.
Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
Zygomaticomaxillary suture maturation evaluation in patients with and without cleft lip and palate.
Li R, Shan Y, Li Y, Huang S, Tong Q, Zhou Z, Zheng M, Zhang X, Weng M, Chen Z
Am J Orthod Dentofacial Orthop 2022 Aug;162(2):162-172. Epub 2022 May 30 doi: 10.1016/j.ajodo.2021.01.030. PMID: 35654687
A predictor of a postoperative fistula after double-opposing Z-plasty in bilateral cleft lip and palate patients.
Kobayashi S, Yabuki Y, Kokubo K, Yasumura K, Hirakawa T, Fukawa T, Yamamoto K
J Plast Reconstr Aesthet Surg 2022 Jun;75(6):1931-1936. Epub 2022 Jan 31 doi: 10.1016/j.bjps.2022.01.038. PMID: 35181246
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Long-Term Otologic and Audiometric Outcomes in Patients with Cleft Palate.
Imbery TE, Sobin LB, Commesso E, Koester L, Tatum SA, Huang D, Wang D, Nicholas BD
Otolaryngol Head Neck Surg 2017 Oct;157(4):676-682. Epub 2017 Jun 27 doi: 10.1177/0194599817707514. PMID: 28653563

Clinical prediction guides

Long-term Follow-up of Bilateral Cleft Lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation.
Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
Zygomaticomaxillary suture maturation evaluation in patients with and without cleft lip and palate.
Li R, Shan Y, Li Y, Huang S, Tong Q, Zhou Z, Zheng M, Zhang X, Weng M, Chen Z
Am J Orthod Dentofacial Orthop 2022 Aug;162(2):162-172. Epub 2022 May 30 doi: 10.1016/j.ajodo.2021.01.030. PMID: 35654687
A predictor of a postoperative fistula after double-opposing Z-plasty in bilateral cleft lip and palate patients.
Kobayashi S, Yabuki Y, Kokubo K, Yasumura K, Hirakawa T, Fukawa T, Yamamoto K
J Plast Reconstr Aesthet Surg 2022 Jun;75(6):1931-1936. Epub 2022 Jan 31 doi: 10.1016/j.bjps.2022.01.038. PMID: 35181246
Do Cleft Lip and Palate Types Affect Health-Related Quality of Life of Adolescents?
Crepaldi TA, Vitor LLR, Carrara CFC, Rios D, Cruvinel T, Almeida ALPF, Soares S, Machado MAAM, Oliveira TM
J Craniofac Surg 2019 May/Jun;30(3):829-833. doi: 10.1097/SCS.0000000000005175. PMID: 30845087
Bilateral Cleft Lip and Palate, With Facial Dysplasia: Interdisciplinary Treatment and Long-Term Follow-Up.
Bennun RD, Harfin JH
J Craniofac Surg 2018 Sep;29(6):1441-1444. doi: 10.1097/SCS.0000000000004756. PMID: 30015740

Recent systematic reviews

What is the Effectiveness of Premaxilla Surgical Repositioning and its Stabilization Methods in Mixed Dentition Patients With Bilateral Cleft Lip and Palate?
Normande Neto HV, Oliveira-Neto OB, Ribeiro ILH, Andrade CS, Sales PHDH, Lima FJC
Cleft Palate Craniofac J 2023 Oct;60(10):1211-1219. Epub 2022 May 9 doi: 10.1177/10556656221096304. PMID: 35535395
Cranial Base Angle in Patients With Cleft Lip and Palate-A Systematic Review and Meta-Analysis.
Murugan C, Kailasam V
Cleft Palate Craniofac J 2023 Jan;60(1):39-54. Epub 2021 Nov 17 doi: 10.1177/10556656211053545. PMID: 34787478
Repair Sequence and Management of the Premaxilla in Patients With Bilateral Cleft Lip and Palate: A Systematic Review of the Literature.
Chang IA, Bassiri Gharb B, Papay FA, Rampazzo A
J Craniofac Surg 2022 Mar-Apr 01;33(2):421-425. doi: 10.1097/SCS.0000000000008184. PMID: 34560740
Effects of labial adhesion on maxillary arch dimensions and nasolabial esthetics in cleft lip and palate: a systematic review.
Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905
Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate.
Guo J, Li C, Zhang Q, Wu G, Deacon SA, Chen J, Hu H, Zou S, Ye Q
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008050. doi: 10.1002/14651858.CD008050.pub2. PMID: 21678372

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