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Fetus Small for Gestational Age with Abnormal Doppler

MedGen UID:
858714
•Concept ID:
C3899120
•
Disease or Syndrome
Synonyms: Fetal SGA with Abnormal Doppler; Fetal Small for Gestational Age with Abnormal Doppler

Definition

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetus Small for Gestational Age with Abnormal Doppler

Professional guidelines

PubMed

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth.
Salomon LJ, Alfirevic Z, Da Silva Costa F, Deter RL, Figueras F, Ghi T, Glanc P, Khalil A, Lee W, Napolitano R, Papageorghiou A, Sotiriadis A, Stirnemann J, Toi A, Yeo G
Ultrasound Obstet Gynecol 2019 Jun;53(6):715-723. doi: 10.1002/uog.20272. PMID: 31169958
Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol.
Figueras F, Gratacós E
Fetal Diagn Ther 2014;36(2):86-98. Epub 2014 Jan 23 doi: 10.1159/000357592. PMID: 24457811

Recent clinical studies

Etiology

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Abnormal Fetal Growth: Small for Gestational Age, Fetal Growth Restriction, Large for Gestational Age: Definitions and Epidemiology.
Damhuis SE, Ganzevoort W, Gordijn SJ
Obstet Gynecol Clin North Am 2021 Jun;48(2):267-279. doi: 10.1016/j.ogc.2021.02.002. PMID: 33972065
ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth.
Salomon LJ, Alfirevic Z, Da Silva Costa F, Deter RL, Figueras F, Ghi T, Glanc P, Khalil A, Lee W, Napolitano R, Papageorghiou A, Sotiriadis A, Stirnemann J, Toi A, Yeo G
Ultrasound Obstet Gynecol 2019 Jun;53(6):715-723. doi: 10.1002/uog.20272. PMID: 31169958
The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention.
Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D'Alton M, Berghella V, Nicolaides KH, Hod M
Int J Gynaecol Obstet 2019 May;145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. PMID: 31111484Free PMC Article
Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol.
Figueras F, Gratacós E
Fetal Diagn Ther 2014;36(2):86-98. Epub 2014 Jan 23 doi: 10.1159/000357592. PMID: 24457811

Diagnosis

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth.
Salomon LJ, Alfirevic Z, Da Silva Costa F, Deter RL, Figueras F, Ghi T, Glanc P, Khalil A, Lee W, Napolitano R, Papageorghiou A, Sotiriadis A, Stirnemann J, Toi A, Yeo G
Ultrasound Obstet Gynecol 2019 Jun;53(6):715-723. doi: 10.1002/uog.20272. PMID: 31169958
The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention.
Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D'Alton M, Berghella V, Nicolaides KH, Hod M
Int J Gynaecol Obstet 2019 May;145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. PMID: 31111484Free PMC Article
Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy.
McCowan LM, Figueras F, Anderson NH
Am J Obstet Gynecol 2018 Feb;218(2S):S855-S868. doi: 10.1016/j.ajog.2017.12.004. PMID: 29422214
Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol.
Figueras F, Gratacós E
Fetal Diagn Ther 2014;36(2):86-98. Epub 2014 Jan 23 doi: 10.1159/000357592. PMID: 24457811

Therapy

Fetal Growth Restriction: A Comprehensive Review of Major Guidelines.
Giouleka S, Tsakiridis I, Mamopoulos A, Kalogiannidis I, Athanasiadis A, Dagklis T
Obstet Gynecol Surv 2023 Nov;78(11):690-708. doi: 10.1097/OGX.0000000000001203. PMID: 38134339
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Planning management and delivery of the growth-restricted fetus.
Baschat AA
Best Pract Res Clin Obstet Gynaecol 2018 May;49:53-65. Epub 2018 Mar 1 doi: 10.1016/j.bpobgyn.2018.02.009. PMID: 29606482
Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy.
McCowan LM, Figueras F, Anderson NH
Am J Obstet Gynecol 2018 Feb;218(2S):S855-S868. doi: 10.1016/j.ajog.2017.12.004. PMID: 29422214
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822

Prognosis

Death and severe morbidity in isolated periviable small-for-gestational-age fetuses.
Meler E, Mazarico E, Peguero A, Gonzalez A, Martinez J, Boada D, Vellvé K, Arca G, Gómez-Roig MD, Gratacós E, Figueras F
BJOG 2023 Apr;130(5):485-493. Epub 2022 Jun 1 doi: 10.1111/1471-0528.17181. PMID: 35437890
The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention.
Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D'Alton M, Berghella V, Nicolaides KH, Hod M
Int J Gynaecol Obstet 2019 May;145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. PMID: 31111484Free PMC Article
Clinical significance of cerebroplacental ratio.
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319
Association between maternal vascular murmur and the small-for-gestational-age fetus with abnormal umbilical artery Doppler flow.
Riknagel D, Farlie R, Hedegaard M, Humaidan P, Struijk JJ
Int J Gynaecol Obstet 2017 Nov;139(2):211-216. Epub 2017 Aug 7 doi: 10.1002/ijgo.12268. PMID: 28718893
Use of Doppler velocimetry in diagnosis and prognosis of intrauterine growth restriction (IUGR): A Review.
Aditya I, Tat V, Sawana A, Mohamed A, Tuffner R, Mondal T
J Neonatal Perinatal Med 2016 May 18;9(2):117-26. doi: 10.3233/NPM-16915132. PMID: 27197939

Clinical prediction guides

Second trimester abnormal uterine artery Dopplers and adverse obstetric and neonatal outcomes when PAPP-a is normal.
Jie M, Jaufuraully S, Lambert J, Napolitano R, Siassakos D
J Matern Fetal Neonatal Med 2023 Dec;36(2):2230515. doi: 10.1080/14767058.2023.2230515. PMID: 37401032
Death and severe morbidity in isolated periviable small-for-gestational-age fetuses.
Meler E, Mazarico E, Peguero A, Gonzalez A, Martinez J, Boada D, Vellvé K, Arca G, Gómez-Roig MD, Gratacós E, Figueras F
BJOG 2023 Apr;130(5):485-493. Epub 2022 Jun 1 doi: 10.1111/1471-0528.17181. PMID: 35437890
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention.
Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D'Alton M, Berghella V, Nicolaides KH, Hod M
Int J Gynaecol Obstet 2019 May;145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. PMID: 31111484Free PMC Article
Clinical significance of cerebroplacental ratio.
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319

Recent systematic reviews

Adverse intrapartum outcome in pregnancies complicated by small for gestational age and late fetal growth restriction undergoing induction of labor with Dinoprostone, Misoprostol or mechanical methods: A systematic review and meta-analysis.
Familiari A, Khalil A, Rizzo G, Odibo A, Vergani P, Buca D, Hidaka N, Di Mascio D, Nwabuobi C, Simeone S, Mecacci F, Visentin S, Cosmi E, Liberati M, D'Amico A, Flacco ME, Martellucci CA, Manzoli L, Nappi L, Iacovella C, Bahlmann F, Melchiorre K, Scambia G, Berghella V, D'Antonio F
Eur J Obstet Gynecol Reprod Biol 2020 Sep;252:455-467. Epub 2020 Jul 18 doi: 10.1016/j.ejogrb.2020.07.020. PMID: 32738675
Fetal intra-abdominal umbilical vein varix: retrospective cohort study and systematic review and meta-analysis.
di Pasquo E, Kuleva M, O'Gorman N, Ville Y, Salomon LJ
Ultrasound Obstet Gynecol 2018 May;51(5):580-585. doi: 10.1002/uog.18895. PMID: 28876490
Impact of cerebral redistribution on neurodevelopmental outcome in small-for-gestational-age or growth-restricted babies: a systematic review.
Meher S, Hernandez-Andrade E, Basheer SN, Lees C
Ultrasound Obstet Gynecol 2015 Oct;46(4):398-404. doi: 10.1002/uog.14818. PMID: 25683973
Systematic review and meta-analysis of middle cerebral artery Doppler to predict perinatal wellbeing.
Morris RK, Say R, Robson SC, Kleijnen J, Khan KS
Eur J Obstet Gynecol Reprod Biol 2012 Dec;165(2):141-55. Epub 2012 Aug 15 doi: 10.1016/j.ejogrb.2012.07.027. PMID: 22901972
Neurodevelopmental delay in small babies at term: a systematic review.
Arcangeli T, Thilaganathan B, Hooper R, Khan KS, Bhide A
Ultrasound Obstet Gynecol 2012 Sep;40(3):267-75. Epub 2012 Aug 7 doi: 10.1002/uog.11112. PMID: 22302630

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