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Congenital Varicella Zoster Infection

MedGen UID:
859096
•Concept ID:
C3899502
•
Disease or Syndrome

Definition

An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital Varicella Zoster Infection

Professional guidelines

PubMed

Monkeypox in pregnancy: virology, clinical presentation, and obstetric management.
Dashraath P, Nielsen-Saines K, Rimoin A, Mattar CNZ, Panchaud A, Baud D
Am J Obstet Gynecol 2022 Dec;227(6):849-861.e7. Epub 2022 Aug 17 doi: 10.1016/j.ajog.2022.08.017. PMID: 35985514Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Herpesviridae Infection: Prevention, Screening, and Management.
Subramaniam A, Britt WJ
Clin Obstet Gynecol 2018 Mar;61(1):157-176. doi: 10.1097/GRF.0000000000000335. PMID: 29283902

Recent clinical studies

Etiology

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Cerebrovascular events after herpes zoster infection: a risk that should be not underestimated.
Zuin M, Rigatelli G, Adami A
J Neurovirol 2019 Aug;25(4):439-447. Epub 2019 May 8 doi: 10.1007/s13365-019-00748-9. PMID: 31069708
Skin infections in pregnancy.
Müllegger RR, Häring NS, Glatz M
Clin Dermatol 2016 May-Jun;34(3):368-77. Epub 2016 Feb 9 doi: 10.1016/j.clindermatol.2016.02.009. PMID: 27265075
IUGR and infections.
Longo S, Borghesi A, Tzialla C, Stronati M
Early Hum Dev 2014 Mar;90 Suppl 1:S42-4. doi: 10.1016/S0378-3782(14)70014-3. PMID: 24709457

Diagnosis

Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Acute Oral Lesions.
France K, Villa A
Dermatol Clin 2020 Oct;38(4):441-450. doi: 10.1016/j.det.2020.05.005. PMID: 32892853
Lights and Shadows of TORCH Infection Proteomics.
Macedo-da-Silva J, Marinho CRF, Palmisano G, Rosa-Fernandes L
Genes (Basel) 2020 Aug 5;11(8) doi: 10.3390/genes11080894. PMID: 32764347Free PMC Article
Intracranial calcifications in childhood: Part 1.
Gonçalves FG, Caschera L, Teixeira SR, Viaene AN, Pinelli L, Mankad K, Alves CAPF, Ortiz-Gonzalez XR, Andronikou S, Vossough A
Pediatr Radiol 2020 Sep;50(10):1424-1447. Epub 2020 Jul 30 doi: 10.1007/s00247-020-04721-1. PMID: 32734340
Herpesviridae Infection: Prevention, Screening, and Management.
Subramaniam A, Britt WJ
Clin Obstet Gynecol 2018 Mar;61(1):157-176. doi: 10.1097/GRF.0000000000000335. PMID: 29283902

Therapy

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Cerebrovascular events after herpes zoster infection: a risk that should be not underestimated.
Zuin M, Rigatelli G, Adami A
J Neurovirol 2019 Aug;25(4):439-447. Epub 2019 May 8 doi: 10.1007/s13365-019-00748-9. PMID: 31069708
Herpesviridae Infection: Prevention, Screening, and Management.
Subramaniam A, Britt WJ
Clin Obstet Gynecol 2018 Mar;61(1):157-176. doi: 10.1097/GRF.0000000000000335. PMID: 29283902
Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment.
Bialas KM, Swamy GK, Permar SR
Clin Perinatol 2015 Mar;42(1):61-75, viii. Epub 2014 Nov 28 doi: 10.1016/j.clp.2014.10.006. PMID: 25677997Free PMC Article
The role of VariZIG in pregnancy.
Bapat P, Koren G
Expert Rev Vaccines 2013 Nov;12(11):1243-8. Epub 2013 Oct 4 doi: 10.1586/14760584.2013.844651. PMID: 24093779

Prognosis

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Lights and Shadows of TORCH Infection Proteomics.
Macedo-da-Silva J, Marinho CRF, Palmisano G, Rosa-Fernandes L
Genes (Basel) 2020 Aug 5;11(8) doi: 10.3390/genes11080894. PMID: 32764347Free PMC Article
Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns.
Holland C, Sadarangani M
Arch Dis Child Educ Pract Ed 2020 Feb;105(1):24-30. Epub 2019 May 23 doi: 10.1136/archdischild-2018-316715. PMID: 31122930
Skin infections in pregnancy.
Müllegger RR, Häring NS, Glatz M
Clin Dermatol 2016 May-Jun;34(3):368-77. Epub 2016 Feb 9 doi: 10.1016/j.clindermatol.2016.02.009. PMID: 27265075
Congenital varicella syndrome: A systematic review.
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725

Clinical prediction guides

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?
Majewska A, Mlynarczyk-Bonikowska B
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073431. PMID: 35408788Free PMC Article
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Lights and Shadows of TORCH Infection Proteomics.
Macedo-da-Silva J, Marinho CRF, Palmisano G, Rosa-Fernandes L
Genes (Basel) 2020 Aug 5;11(8) doi: 10.3390/genes11080894. PMID: 32764347Free PMC Article
Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns.
Holland C, Sadarangani M
Arch Dis Child Educ Pract Ed 2020 Feb;105(1):24-30. Epub 2019 May 23 doi: 10.1136/archdischild-2018-316715. PMID: 31122930
Childhood peripheral facial palsy.
Karalok ZS, Taskin BD, Ozturk Z, Gurkas E, Koc TB, Guven A
Childs Nerv Syst 2018 May;34(5):911-917. Epub 2018 Feb 9 doi: 10.1007/s00381-018-3742-9. PMID: 29427137

Recent systematic reviews

Congenital varicella syndrome: A systematic review.
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725
Incidence and use of resources for chickenpox and herpes zoster in Latin America and the Caribbean--a systematic review and meta-analysis.
Bardach A, Cafferata ML, Klein K, Cormick G, Gibbons L, Ruvinsky S
Pediatr Infect Dis J 2012 Dec;31(12):1263-8. doi: 10.1097/INF.0b013e31826ff3a5. PMID: 23188098
Sonographic findings in fetal viral infections: a systematic review.
Degani S
Obstet Gynecol Surv 2006 May;61(5):329-36. doi: 10.1097/01.ogx.0000216518.85796.88. PMID: 16635273

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