U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anti-D Hemolytic Disease of the Newborn

MedGen UID:
859621
•Concept ID:
C3900027
•
Disease or Syndrome
Synonym: Isoimmunization of Newborn with Rhesus Anti-D Antibody

Definition

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-D Hemolytic Disease of the Newborn

Professional guidelines

PubMed

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
Fetal and Neonatal Alloimmune Thrombocytopenia-New Prospects for Fetal Risk Assessment of HPA-1a-Negative Pregnant Women.
Kjeldsen-Kragh J, Bengtsson J
Transfus Med Rev 2020 Oct;34(4):270-276. Epub 2020 Sep 16 doi: 10.1016/j.tmrv.2020.09.004. PMID: 33039264
RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277

Recent clinical studies

Etiology

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.
Pegoraro V, Urbinati D, Visser GHA, Di Renzo GC, Zipursky A, Stotler BA, Spitalnik SL
PLoS One 2020;15(7):e0235807. Epub 2020 Jul 20 doi: 10.1371/journal.pone.0235807. PMID: 32687543Free PMC Article
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660

Diagnosis

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
Hemolytic disease of the fetus and newborn in the sensitizing pregnancy where anti-D was incorrectly identified as RhIG.
Walhof ML, Leon J, Greiner AL, Scott JR, Knudson CM
J Clin Lab Anal 2022 Apr;36(4):e24323. Epub 2022 Mar 3 doi: 10.1002/jcla.24323. PMID: 35243688Free PMC Article
RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660

Therapy

RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.
Pegoraro V, Urbinati D, Visser GHA, Di Renzo GC, Zipursky A, Stotler BA, Spitalnik SL
PLoS One 2020;15(7):e0235807. Epub 2020 Jul 20 doi: 10.1371/journal.pone.0235807. PMID: 32687543Free PMC Article
Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.
Brinc D, Lazarus AH
Hematology Am Soc Hematol Educ Program 2009:185-91. doi: 10.1182/asheducation-2009.1.185. PMID: 20008198
Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn: what can we learn from rodent models?
Brinc D, Denomme GA, Lazarus AH
Curr Opin Hematol 2009 Nov;16(6):488-96. doi: 10.1097/MOH.0b013e32833199ed. PMID: 19730101
Haemolytic disease of newborn.
Narang A, Jain N
Indian J Pediatr 2001 Feb;68(2):167-72. doi: 10.1007/BF02722039. PMID: 11284186

Prognosis

Reassessment of Critical Anti-D Antibody Titer in RhD Alloimmunized Antenatal Women.
Singh B, Chaudhary R, Katharia R
Lab Med 2023 Jul 5;54(4):429-433. doi: 10.1093/labmed/lmac149. PMID: 36539334
Tacrolimus treatment saved a rho-incompatible pregnancy.
Nakagawa K, Funaki S, Hisano M, Sugiyama R, Yamaguchi K
J Matern Fetal Neonatal Med 2020 Nov;33(22):3873-3876. Epub 2019 Mar 8 doi: 10.1080/14767058.2019.1587406. PMID: 30821534
Lessons learned from the implementation of non-invasive fetal RHD screening.
Clausen FB
Expert Rev Mol Diagn 2018 May;18(5):423-431. Epub 2018 Apr 19 doi: 10.1080/14737159.2018.1461562. PMID: 29616835
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
The role of Rh antibodies in haemolytic disease of the newborn.
Hadley AG, Kumpel BM
Baillieres Clin Haematol 1993 Jun;6(2):423-44. doi: 10.1016/s0950-3536(05)80153-2. PMID: 8043933

Clinical prediction guides

Reassessment of Critical Anti-D Antibody Titer in RhD Alloimmunized Antenatal Women.
Singh B, Chaudhary R, Katharia R
Lab Med 2023 Jul 5;54(4):429-433. doi: 10.1093/labmed/lmac149. PMID: 36539334
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Lessons learned from the implementation of non-invasive fetal RHD screening.
Clausen FB
Expert Rev Mol Diagn 2018 May;18(5):423-431. Epub 2018 Apr 19 doi: 10.1080/14737159.2018.1461562. PMID: 29616835
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
In vivo studies of monoclonal anti-D and the mechanism of immune suppression.
Kumpel BM
Transfus Clin Biol 2002 Jan;9(1):9-14. doi: 10.1016/s1246-7820(01)00209-9. PMID: 11889904

Recent systematic reviews

Misclassification of RhD variants among pregnant women: a systematic review.
Owaidah AY, Yamani LZ
J Med Life 2023 Jul;16(7):981-989. doi: 10.25122/jml-2023-0004. PMID: 37900088Free PMC Article
Non-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Alshehri AA, Jackson DE
Transfus Med Rev 2021 Apr;35(2):85-94. Epub 2021 Mar 1 doi: 10.1016/j.tmrv.2021.02.001. PMID: 33781630
Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation.
Karanth L, Jaafar SH, Kanagasabai S, Nair NS, Barua A
Cochrane Database Syst Rev 2013 Mar 28;(3):CD009617. doi: 10.1002/14651858.CD009617.pub2. PMID: 23543581

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...