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Sensitivity to genotoxic agents

MedGen UID:
863901
•Concept ID:
C4015464
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSensitivity to genotoxic agents

Professional guidelines

PubMed

Future directions and treatment strategies for head and neck squamous cell carcinomas.
Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI
Transl Res 2012 Sep;160(3):167-77. Epub 2012 Feb 28 doi: 10.1016/j.trsl.2012.02.002. PMID: 22683420Free PMC Article

Recent clinical studies

Etiology

Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Chromosomal aberrations, clastogens vs aneugens.
Mishima M
Front Biosci (Schol Ed) 2017 Jan 1;9(1):1-16. doi: 10.2741/s468. PMID: 27814570
Rothmund-Thomson syndrome.
Larizza L, Roversi G, Volpi L
Orphanet J Rare Dis 2010 Jan 29;5:2. doi: 10.1186/1750-1172-5-2. PMID: 20113479Free PMC Article
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Diagnosis

Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies.
Bhardwaj JK, Bikal P, Sachdeva SN
J Biochem Mol Toxicol 2023 Jul;37(7):e23371. Epub 2023 Apr 26 doi: 10.1002/jbt.23371. PMID: 37098697
Chromosomal aberrations, clastogens vs aneugens.
Mishima M
Front Biosci (Schol Ed) 2017 Jan 1;9(1):1-16. doi: 10.2741/s468. PMID: 27814570
The comet assay for DNA damage and repair: principles, applications, and limitations.
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Therapy

Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies.
Bhardwaj JK, Bikal P, Sachdeva SN
J Biochem Mol Toxicol 2023 Jul;37(7):e23371. Epub 2023 Apr 26 doi: 10.1002/jbt.23371. PMID: 37098697
Categorizing the characteristics of human carcinogens: a need for specificity.
Smith CJ, Perfetti TA, Hayes AW, Berry SC, Trosko JE, King JA, Goodman JI, Begley CG, Dayan A
Arch Toxicol 2021 Aug;95(8):2883-2889. Epub 2021 Jun 20 doi: 10.1007/s00204-021-03109-w. PMID: 34148101
Biological effects of essential oils--a review.
Bakkali F, Averbeck S, Averbeck D, Idaomar M
Food Chem Toxicol 2008 Feb;46(2):446-75. Epub 2007 Sep 29 doi: 10.1016/j.fct.2007.09.106. PMID: 17996351
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Prognosis

Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies.
Bhardwaj JK, Bikal P, Sachdeva SN
J Biochem Mol Toxicol 2023 Jul;37(7):e23371. Epub 2023 Apr 26 doi: 10.1002/jbt.23371. PMID: 37098697
Cytokinesis Blocked Micronuclei Aberration Analysis.
Kato TA
Methods Mol Biol 2023;2519:83-91. doi: 10.1007/978-1-0716-2433-3_9. PMID: 36066712
Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens.
Bhagat J
J Appl Toxicol 2018 Jan;38(1):81-99. Epub 2017 Jul 11 doi: 10.1002/jat.3496. PMID: 28695982
Sister chromatid exchange assay as a predictor of tumor chemoresponse.
Mourelatos D
Mutat Res Genet Toxicol Environ Mutagen 2016 Jun;803-804:1-12. Epub 2016 May 7 doi: 10.1016/j.mrgentox.2016.03.011. PMID: 27265374

Clinical prediction guides

Cytokinesis Blocked Micronuclei Aberration Analysis.
Kato TA
Methods Mol Biol 2023;2519:83-91. doi: 10.1007/978-1-0716-2433-3_9. PMID: 36066712
Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Comet assay in ecogenotoxicology: Applications in Mytilus sp.
Bolognesi C, Cirillo S, Chipman JK
Mutat Res Genet Toxicol Environ Mutagen 2019 Jun;842:50-59. Epub 2019 May 8 doi: 10.1016/j.mrgentox.2019.05.004. PMID: 31255226
Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens.
Bhagat J
J Appl Toxicol 2018 Jan;38(1):81-99. Epub 2017 Jul 11 doi: 10.1002/jat.3496. PMID: 28695982
The comet assay for DNA damage and repair: principles, applications, and limitations.
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294

Recent systematic reviews

Is micronucleus assay in nasal mucosa cells an appropriate technique for detecting genotoxins by inhalation in humans? A systematic review.
Drummond GWB, de Moraes Malinverni AC, Renno ACM, Ribeiro DA
Int J Environ Health Res 2024 Mar;34(3):1664-1674. Epub 2023 Jul 13 doi: 10.1080/09603123.2023.2234300. PMID: 37442547
Systematic review of comparative transcriptomic studies of cellular resistance to genotoxic stress.
Ismailov ZB, Belykh ES, Chernykh AA, Udoratina AM, Kazakov DV, Rybak AV, Kerimova SN, Velegzhaninov IO
Mutat Res Rev Mutat Res 2023 Jul-Dec;792:108467. Epub 2023 Aug 30 doi: 10.1016/j.mrrev.2023.108467. PMID: 37657754
The role of the enzyme-modified comet assay in in vivo studies.
Collins A, Vettorazzi A, Azqueta A
Toxicol Lett 2020 Jul 1;327:58-68. Epub 2020 Apr 2 doi: 10.1016/j.toxlet.2020.03.016. PMID: 32247831

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