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Bridged palmar crease

MedGen UID:
866812
•Concept ID:
C4021166
•
Anatomical Abnormality
Synonyms: Bridged palm line; Transitional palmar crease
 
HPO: HP:0011310

Definition

A crease that connects the proximal and distal transverse palmar creases. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBridged palmar crease

Recent clinical studies

Etiology

Toluene embryopathy: clinical delineation and developmental follow-up.
Arnold GL, Kirby RS, Langendoerfer S, Wilkins-Haug L
Pediatrics 1994 Feb;93(2):216-20. PMID: 7510062
Terminal and interstitial deletions of the long arm of chromosome 7: a review with five new cases.
Young RS, Weaver DD, Kukolich MK, Heerema NA, Palmer CG, Kawira EL, Bender HA
Am J Med Genet 1984 Feb;17(2):437-50. doi: 10.1002/ajmg.1320170207. PMID: 6199974

Diagnosis

A de novo heterozygous variant in the SON gene is associated with Zhu-Tokita-Takenouchi-Kim syndrome.
Yang L, Yang F
Mol Genet Genomic Med 2020 Nov;8(11):e1496. Epub 2020 Sep 14 doi: 10.1002/mgg3.1496. PMID: 32926520Free PMC Article
Further delineation of the phenotype of truncating KMT2A mutations: The extended Wiedemann-Steiner syndrome.
Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, Wang L, Fan Y, Gu X, Yu Y
Am J Med Genet A 2017 Feb;173(2):510-514. Epub 2016 Oct 19 doi: 10.1002/ajmg.a.38025. PMID: 27759909
De novo ring chromosome 6 in a child with multiple congenital anomalies.
Ahzad HA, Ramli SF, Loong TM, Salahshourifar I, Zilfalil BA, Yusoff NM
Kobe J Med Sci 2010 Sep 28;56(2):E79-84. PMID: 21063149
A report of a patient with duplication of 7p13-->pter and deletion of 2p23-->pter due to a maternal 2p;7p translocation.
Türköver BB, Sayar C, Toksoy G, Elçioğlu N
Turk J Pediatr 2009 Mar-Apr;51(2):174-9. PMID: 19480332
Further delineation of the C (trigonocephaly) syndrome.
Antley RM, Hwang DS, Theopold W, Gorlin RJ, Steeper T, Pitt D, Danks DM, McPherson E, Bartels H, Wiedemann HR, Opitz JM
Am J Med Genet 1981;9(2):147-63. doi: 10.1002/ajmg.1320090209. PMID: 7258228

Therapy

Toluene embryopathy: clinical delineation and developmental follow-up.
Arnold GL, Kirby RS, Langendoerfer S, Wilkins-Haug L
Pediatrics 1994 Feb;93(2):216-20. PMID: 7510062

Prognosis

Toluene embryopathy: clinical delineation and developmental follow-up.
Arnold GL, Kirby RS, Langendoerfer S, Wilkins-Haug L
Pediatrics 1994 Feb;93(2):216-20. PMID: 7510062

Clinical prediction guides

Further delineation of the phenotype of truncating KMT2A mutations: The extended Wiedemann-Steiner syndrome.
Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, Wang L, Fan Y, Gu X, Yu Y
Am J Med Genet A 2017 Feb;173(2):510-514. Epub 2016 Oct 19 doi: 10.1002/ajmg.a.38025. PMID: 27759909
Furrows and dermal ridges of the hand in patients with alcohol embryopathy.
Tillner I, Majewski F
Hum Genet 1978 Jun 27;42(3):307-14. doi: 10.1007/BF00291311. PMID: 566712

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