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Abnormality of the twelfth cranial nerve

MedGen UID:
866869
•Concept ID:
C4021224
•
Anatomical Abnormality
Synonyms: Abnormality of cranial nerve 12; Abnormality of cranial nerve xii; Abnormality of the hypoglossal nerve
 
HPO: HP:0010826

Definition

Abnormality of the twelfth cranial nerve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the twelfth cranial nerve

Professional guidelines

PubMed

Management of residual OSA post adenotonsillectomy in children with Down Syndrome: A systematic review.
Ravutha Gounden M, Chawla JK
Int J Pediatr Otorhinolaryngol 2022 Jan;152:110966. Epub 2021 Nov 10 doi: 10.1016/j.ijporl.2021.110966. PMID: 34785079
Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea.
Kezirian EJ, Boudewyns A, Eisele DW, Schwartz AR, Smith PL, Van de Heyning PH, De Backer WA
Sleep Med Rev 2010 Oct;14(5):299-305. Epub 2010 Jan 29 doi: 10.1016/j.smrv.2009.10.009. PMID: 20116305
Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements.
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880

Recent clinical studies

Etiology

Management of residual OSA post adenotonsillectomy in children with Down Syndrome: A systematic review.
Ravutha Gounden M, Chawla JK
Int J Pediatr Otorhinolaryngol 2022 Jan;152:110966. Epub 2021 Nov 10 doi: 10.1016/j.ijporl.2021.110966. PMID: 34785079
Is Basilar Invagination Related with Stenosis of the Hypoglossal Nerve Canal?
Vasconcelos BB, Nascimento JJC, Valença MM, Silva-Neto EJ, Diniz PRB, Araújo-Neto SA
World Neurosurg 2020 May;137:e354-e357. Epub 2020 Feb 4 doi: 10.1016/j.wneu.2020.01.209. PMID: 32032789
Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury.
Hu R, Li Y, Xu W, Cheng L, Ren H
J Voice 2017 Jan;31(1):126.e1-126.e6. Epub 2016 Feb 1 doi: 10.1016/j.jvoice.2015.12.016. PMID: 26846541
Occipital condyle syndrome.
Capobianco DJ, Brazis PW, Rubino FA, Dalton JN
Headache 2002 Feb;42(2):142-6. doi: 10.1046/j.1526-4610.2002.02032.x. PMID: 12005291
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081

Diagnosis

Cranial Nerve Disorders in Children: MR Imaging Findings.
Hwang JY, Yoon HK, Lee JH, Yoon HM, Jung AY, Cho YA, Lee JS, Yoon CH
Radiographics 2016 Jul-Aug;36(4):1178-94. doi: 10.1148/rg.2016150163. PMID: 27399242
Eagle's Syndrome.
Elimairi I, Baur DA, Altay MA, Quereshy FA, Minisandram A
Head Neck Pathol 2015 Dec;9(4):492-5. Epub 2014 Dec 24 doi: 10.1007/s12105-014-0599-4. PMID: 25537830Free PMC Article
Respiratory motoneurons and pathological conditions: lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress.
Cifra A, Nani F, Nistri A
Respir Physiol Neurobiol 2011 Oct 15;179(1):89-96. Epub 2011 Apr 2 doi: 10.1016/j.resp.2011.03.017. PMID: 21443969
Dementia with motor neuron disease.
Mitsuyama Y
Neuropathology 2000 Sep;20 Suppl:S79-81. doi: 10.1046/j.1440-1789.2000.00302.x. PMID: 11037194
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081

Therapy

Long-term stability of hypoglossal nerve stimulation for the treatment of obstructive sleep apnea in children with Down syndrome.
Stenerson ME, Yu PK, Kinane TB, Skotko BG, Hartnick CJ
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110868. Epub 2021 Aug 5 doi: 10.1016/j.ijporl.2021.110868. PMID: 34371294
A novel surgical protocol for safe and accurate placement of C1 lateral mass screws in patients with atlas assimilation, basilar invagination and atlantoaxial instability: technical details, accuracy assessment and perioperative complications.
Du YQ, Yin YH, Li T, Qiao GY, Yu XG
Eur Spine J 2021 Jun;30(6):1585-1595. Epub 2021 Mar 11 doi: 10.1007/s00586-021-06780-w. PMID: 33704580
Idiopathic Isolated Unilateral Hypoglossal Nerve Palsy: A Report of 2 Cases and Review of the Literature.
Shibata A, Kimura M, Ishibashi K, Umemura M
J Oral Maxillofac Surg 2018 Jul;76(7):1454-1459. Epub 2018 Feb 2 doi: 10.1016/j.joms.2018.01.019. PMID: 29452069
Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure.
Sunderram J, Parisi RA, Strobel RJ
Am J Respir Crit Care Med 2000 Sep;162(3 Pt 1):925-9. doi: 10.1164/ajrccm.162.3.9907077. PMID: 10988107
Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements.
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880

Prognosis

Cranial Nerve Disorders in Children: MR Imaging Findings.
Hwang JY, Yoon HK, Lee JH, Yoon HM, Jung AY, Cho YA, Lee JS, Yoon CH
Radiographics 2016 Jul-Aug;36(4):1178-94. doi: 10.1148/rg.2016150163. PMID: 27399242
Lateral congenital anomalies of the pharyngeal apparatus: part II. anatomy of the abnormal for the surgeon.
Mirilas P
Am Surg 2011 Sep;77(9):1243-56. PMID: 21944635
Dementia with motor neuron disease.
Mitsuyama Y
Neuropathology 2000 Sep;20 Suppl:S79-81. doi: 10.1046/j.1440-1789.2000.00302.x. PMID: 11037194
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081
Amaurosis fugax.
Mungas JE, Baker WH
Stroke 1977 Mar-Apr;8(2):232-5. doi: 10.1161/01.str.8.2.232. PMID: 847787

Clinical prediction guides

Long-term stability of hypoglossal nerve stimulation for the treatment of obstructive sleep apnea in children with Down syndrome.
Stenerson ME, Yu PK, Kinane TB, Skotko BG, Hartnick CJ
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110868. Epub 2021 Aug 5 doi: 10.1016/j.ijporl.2021.110868. PMID: 34371294
Syringobulbia in pediatric patients with Chiari malformation type I.
Menezes AH, Greenlee JDW, Dlouhy BJ
J Neurosurg Pediatr 2018 Jul;22(1):52-60. Epub 2018 Apr 27 doi: 10.3171/2018.1.PEDS17472. PMID: 29701558
Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury.
Hu R, Li Y, Xu W, Cheng L, Ren H
J Voice 2017 Jan;31(1):126.e1-126.e6. Epub 2016 Feb 1 doi: 10.1016/j.jvoice.2015.12.016. PMID: 26846541
Respiratory motoneurons and pathological conditions: lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress.
Cifra A, Nani F, Nistri A
Respir Physiol Neurobiol 2011 Oct 15;179(1):89-96. Epub 2011 Apr 2 doi: 10.1016/j.resp.2011.03.017. PMID: 21443969
Amaurosis fugax.
Mungas JE, Baker WH
Stroke 1977 Mar-Apr;8(2):232-5. doi: 10.1161/01.str.8.2.232. PMID: 847787

Recent systematic reviews

Management of residual OSA post adenotonsillectomy in children with Down Syndrome: A systematic review.
Ravutha Gounden M, Chawla JK
Int J Pediatr Otorhinolaryngol 2022 Jan;152:110966. Epub 2021 Nov 10 doi: 10.1016/j.ijporl.2021.110966. PMID: 34785079
Referral of adults with obstructive sleep apnea for surgical consultation: an American Academy of Sleep Medicine clinical practice guideline.
Kent D, Stanley J, Aurora RN, Levine C, Gottlieb DJ, Spann MD, Torre CA, Green K, Harrod CG
J Clin Sleep Med 2021 Dec 1;17(12):2499-2505. doi: 10.5664/jcsm.9592. PMID: 34351848Free PMC Article

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