U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal epiphysis morphology

MedGen UID:
867251
Concept ID:
C4021611
Anatomical Abnormality
Synonyms: Abnormal shape of end part of bone; Abnormality of epiphysis morphology; Abnormality of the epiphyses; Anomaly of the epiphyses; Epiphyseal abnormality
 
HPO: HP:0005930

Definition

An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal epiphysis morphology

Professional guidelines

PubMed

Carter EM, Davis JG, Raggio CL
Curr Opin Pediatr 2007 Feb;19(1):32-7. doi: 10.1097/MOP.0b013e328013e3d9. PMID: 17224659
Hickman JM, Peters CL
Am J Orthop (Belle Mead NJ) 2001 Jun;30(6):459-67. PMID: 11411872
Bryant DD 3rd, Epps CH Jr
Orthopedics 1991 Jul;14(7):775-84. doi: 10.3928/0147-7447-19910701-08. PMID: 1871029

Recent clinical studies

Etiology

Handa A, Voss U, Hammarsjö A, Grigelioniene G, Nishimura G
Jpn J Radiol 2020 Mar;38(3):193-206. Epub 2020 Jan 21 doi: 10.1007/s11604-020-00920-w. PMID: 31965514
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article
Chan G, Chen CT
Curr Opin Pediatr 2009 Feb;21(1):65-70. doi: 10.1097/MOP.0b013e328320a914. PMID: 19242242
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Diagnosis

Morancie NA, Helton MR
Am Fam Physician 2023 May;107(5):474-485. PMID: 37192073
Vargas Lebrón C, Ruiz Montesino MD, Moreira Navarrete V, Aróstegui Gorospe JI
Reumatol Clin (Engl Ed) 2020 Nov-Dec;16(6):499-501. Epub 2018 Dec 3 doi: 10.1016/j.reuma.2018.08.015. PMID: 30522940
Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421
Juneja A, Sultan A, Bhatnagar S
J Indian Soc Pedod Prev Dent 2012 Jul-Sep;30(3):250-3. doi: 10.4103/0970-4388.105019. PMID: 23263430
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article

Therapy

Fuente R, García-Bengoa M, Fernández-Iglesias Á, Gil-Peña H, Santos F, López JM
Int J Mol Sci 2022 Jan 15;23(2) doi: 10.3390/ijms23020934. PMID: 35055123Free PMC Article
Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785
Frazier KS
Toxicol Pathol 2017 Oct;45(7):869-875. Epub 2017 Jun 23 doi: 10.1177/0192623317713319. PMID: 28643552
Sederquist B, Fernandez-Vojvodich P, Zaman F, Sävendahl L
J Mol Endocrinol 2014 Aug;53(1):T35-44. Epub 2014 Apr 7 doi: 10.1530/JME-14-0006. PMID: 24711646
Durmus O, Cakar E, Ata E, Dincer U, Kiralp MZ
Am J Phys Med Rehabil 2014 Jan;93(1):92-3. doi: 10.1097/PHM.0b013e3182644034. PMID: 22854906

Prognosis

Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article
Stanescu V, Stanescu R, Maroteaux P
J Bone Joint Surg Am 1984 Jul;66(6):817-36. doi: 10.2106/00004623-198466060-00002. PMID: 6376516
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Clinical prediction guides

Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421
Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675
Harrison RB, Keats TE
Skeletal Radiol 1980 Feb;5(1):23-7. doi: 10.1007/BF00347094. PMID: 6767277
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Recent systematic reviews

Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785
Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572
Nepple JJ, Vigdorchik JM, Clohisy JC
Am J Sports Med 2015 Nov;43(11):2833-40. Epub 2015 Jan 13 doi: 10.1177/0363546514563909. PMID: 25587186
Yammine K
Clin Anat 2014 May;27(4):610-21. Epub 2013 Dec 2 doi: 10.1002/ca.22343. PMID: 24302513
Hogervorst T, Eilander W, Fikkers JT, Meulenbelt I
Clin Orthop Relat Res 2012 Dec;470(12):3284-96. doi: 10.1007/s11999-012-2511-4. PMID: 22926490Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...