U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neoplasm of fatty tissue

MedGen UID:
867518
•Concept ID:
C4021901
•
Neoplastic Process
Synonyms: Tumor of fatty tissue; Tumour of fatty tissue
 
HPO: HP:0200013

Definition

A tumor (abnormal growth of tissue) of adipose tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of fatty tissue

Professional guidelines

PubMed

Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment.
Llovet JM, Willoughby CE, Singal AG, Greten TF, Heikenwälder M, El-Serag HB, Finn RS, Friedman SL
Nat Rev Gastroenterol Hepatol 2023 Aug;20(8):487-503. Epub 2023 Mar 17 doi: 10.1038/s41575-023-00754-7. PMID: 36932227
Cancer-associated cachexia - understanding the tumour macroenvironment and microenvironment to improve management.
Argilés JM, López-Soriano FJ, Stemmler B, Busquets S
Nat Rev Clin Oncol 2023 Apr;20(4):250-264. Epub 2023 Feb 20 doi: 10.1038/s41571-023-00734-5. PMID: 36806788
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Recent clinical studies

Etiology

Metabolic pathways in obesity-related breast cancer.
Brown KA
Nat Rev Endocrinol 2021 Jun;17(6):350-363. Epub 2021 Apr 29 doi: 10.1038/s41574-021-00487-0. PMID: 33927368Free PMC Article
The Importance of Breast Adipose Tissue in Breast Cancer.
Kothari C, Diorio C, Durocher F
Int J Mol Sci 2020 Aug 11;21(16) doi: 10.3390/ijms21165760. PMID: 32796696Free PMC Article
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.
Bhardwaj P, Au CC, Benito-Martin A, Ladumor H, Oshchepkova S, Moges R, Brown KA
J Steroid Biochem Mol Biol 2019 May;189:161-170. Epub 2019 Mar 6 doi: 10.1016/j.jsbmb.2019.03.002. PMID: 30851382Free PMC Article
The obese adipose tissue microenvironment in cancer development and progression.
Quail DF, Dannenberg AJ
Nat Rev Endocrinol 2019 Mar;15(3):139-154. doi: 10.1038/s41574-018-0126-x. PMID: 30459447Free PMC Article
Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.
Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG
Physiol Rev 2017 Oct 1;97(4):1351-1402. doi: 10.1152/physrev.00019.2016. PMID: 28814614Free PMC Article

Diagnosis

Polycystic ovary syndrome and adipose tissue.
Lemaitre M, Christin-Maitre S, Kerlan V
Ann Endocrinol (Paris) 2023 Apr;84(2):308-315. Epub 2023 Jan 7 doi: 10.1016/j.ando.2022.11.004. PMID: 36623807
Lipofibromatosis.
Rastogi K, Singh L
Fetal Pediatr Pathol 2019 Dec;38(6):490-495. Epub 2019 Jun 2 doi: 10.1080/15513815.2019.1619206. PMID: 31154875
The obese adipose tissue microenvironment in cancer development and progression.
Quail DF, Dannenberg AJ
Nat Rev Endocrinol 2019 Mar;15(3):139-154. doi: 10.1038/s41574-018-0126-x. PMID: 30459447Free PMC Article
Fatty Pancreas: Should We Be Concerned?
Majumder S, Philip NA, Takahashi N, Levy MJ, Singh VP, Chari ST
Pancreas 2017 Nov/Dec;46(10):1251-1258. doi: 10.1097/MPA.0000000000000941. PMID: 29040194Free PMC Article
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care.
Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE
Appl Physiol Nutr Metab 2008 Oct;33(5):997-1006. doi: 10.1139/H08-075. PMID: 18923576

Therapy

Understanding the relationship between cancer associated cachexia and hypoxia-inducible factor-1.
Muthamil S, Kim HY, Jang HJ, Lyu JH, Shin UC, Go Y, Park SH, Lee HG, Park JH
Biomed Pharmacother 2023 Jul;163:114802. Epub 2023 May 3 doi: 10.1016/j.biopha.2023.114802. PMID: 37146421
Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.
Lu Y, Tang H, Huang P, Wang J, Deng P, Li Y, Zheng J, Weng L
Int J Epidemiol 2022 Aug 10;51(4):1204-1218. doi: 10.1093/ije/dyac025. PMID: 35218345Free PMC Article
Nutrition in Cancer.
Ravasco P
Nestle Nutr Inst Workshop Ser 2015;82:91-102. Epub 2015 Oct 20 doi: 10.1159/000382004. PMID: 26544599
De novo lipogenesis in health and disease.
Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N
Metabolism 2014 Jul;63(7):895-902. Epub 2014 Apr 12 doi: 10.1016/j.metabol.2014.04.003. PMID: 24814684
Obesity-associated mechanisms of hepatocarcinogenesis.
Karagozian R, Derdák Z, Baffy G
Metabolism 2014 May;63(5):607-17. Epub 2014 Feb 5 doi: 10.1016/j.metabol.2014.01.011. PMID: 24629562

Prognosis

Single-cell analysis of white adipose tissue reveals the tumor-promoting adipocyte subtypes.
Liu SQ, Chen DY, Li B, Gao ZJ, Feng HF, Yu X, Liu Z, Wang Y, Li WG, Sun S, Sun SR, Wu Q
J Transl Med 2023 Jul 15;21(1):470. doi: 10.1186/s12967-023-04256-7. PMID: 37454080Free PMC Article
Metabolic and histomorphological changes of adipose tissue in cachexia.
Molfino A, Imbimbo G, Muscaritoli M
Curr Opin Clin Nutr Metab Care 2023 May 1;26(3):235-242. Epub 2023 Feb 9 doi: 10.1097/MCO.0000000000000923. PMID: 36942899
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases.
Yin X, Chen Y, Ruze R, Xu R, Song J, Wang C, Xu Q
Signal Transduct Target Ther 2022 Sep 16;7(1):324. doi: 10.1038/s41392-022-01178-6. PMID: 36114195Free PMC Article
Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression.
Liu Z, Gao Z, Li B, Li J, Ou Y, Yu X, Zhang Z, Liu S, Fu X, Jin H, Wu J, Sun S, Sun S, Wu Q
Oncoimmunology 2022;11(1):2085432. Epub 2022 Jun 8 doi: 10.1080/2162402X.2022.2085432. PMID: 35712121Free PMC Article
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care.
Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE
Appl Physiol Nutr Metab 2008 Oct;33(5):997-1006. doi: 10.1139/H08-075. PMID: 18923576

Clinical prediction guides

Obesity and prostate cancer - microenvironmental roles of adipose tissue.
Saha A, Kolonin MG, DiGiovanni J
Nat Rev Urol 2023 Oct;20(10):579-596. Epub 2023 May 17 doi: 10.1038/s41585-023-00764-9. PMID: 37198266
Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression.
Liu Z, Gao Z, Li B, Li J, Ou Y, Yu X, Zhang Z, Liu S, Fu X, Jin H, Wu J, Sun S, Sun S, Wu Q
Oncoimmunology 2022;11(1):2085432. Epub 2022 Jun 8 doi: 10.1080/2162402X.2022.2085432. PMID: 35712121Free PMC Article
Obesity, Diabetes, and Increased Cancer Progression.
Kim DS, Scherer PE
Diabetes Metab J 2021 Nov;45(6):799-812. Epub 2021 Nov 22 doi: 10.4093/dmj.2021.0077. PMID: 34847640Free PMC Article
Adipocyte dedifferentiation in health and diseases.
Song T, Kuang S
Clin Sci (Lond) 2019 Oct 30;133(20):2107-2119. doi: 10.1042/CS20190128. PMID: 31654064Free PMC Article
De novo lipogenesis in health and disease.
Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N
Metabolism 2014 Jul;63(7):895-902. Epub 2014 Apr 12 doi: 10.1016/j.metabol.2014.04.003. PMID: 24814684

Recent systematic reviews

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.
Bril F, Ezeh U, Amiri M, Hatoum S, Pace L, Chen YH, Bertrand F, Gower B, Azziz R
J Clin Endocrinol Metab 2023 Dec 21;109(1):10-24. doi: 10.1210/clinem/dgad356. PMID: 37329216Free PMC Article
Adiposity and cancer survival: a systematic review and meta-analysis.
Cheng E, Kirley J, Cespedes Feliciano EM, Caan BJ
Cancer Causes Control 2022 Oct;33(10):1219-1246. Epub 2022 Aug 15 doi: 10.1007/s10552-022-01613-7. PMID: 35971021Free PMC Article
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Lifestyle changes in women with polycystic ovary syndrome.
Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ
Cochrane Database Syst Rev 2019 Mar 28;3(3):CD007506. doi: 10.1002/14651858.CD007506.pub4. PMID: 30921477Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...