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Neoplasm of the nail

MedGen UID:
867576
•Concept ID:
C4021961
•
Neoplastic Process
Synonym: Nail tumor
 
HPO: HP:0100826
Monarch Initiative: MONDO:0017588
Orphanet: ORPHA300515

Definition

A tumor (abnormal growth of tissue) of the nail. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of the nail

Professional guidelines

PubMed

Adult and Pediatric Nail Unit Melanoma: Epidemiology, Diagnosis, and Treatment.
Conway J, Bellet JS, Rubin AI, Lipner SR
Cells 2023 Mar 22;12(6) doi: 10.3390/cells12060964. PMID: 36980308Free PMC Article
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Recent clinical studies

Etiology

The pharmacotherapeutic management of nail unit and acral melanomas.
Falotico JM, Lipner SR
Expert Opin Pharmacother 2022 Aug;23(11):1273-1289. Epub 2022 Jun 14 doi: 10.1080/14656566.2022.2088279. PMID: 35702037
Selenium and cancer risk: Wide-angled Mendelian randomization analysis.
Yuan S, Mason AM, Carter P, Vithayathil M, Kar S, Burgess S, Larsson SC
Int J Cancer 2022 Apr 1;150(7):1134-1140. Epub 2021 Dec 24 doi: 10.1002/ijc.33902. PMID: 34910310Free PMC Article
Nail cosmetics: a dermatological perspective.
Dinani N, George S
Clin Exp Dermatol 2019 Aug;44(6):599-605. Epub 2019 Feb 21 doi: 10.1111/ced.13929. PMID: 30793352
Imaging technique for the diagnosis of onychomatricoma.
Cinotti E, Veronesi G, Labeille B, Cambazard F, Piraccini BM, Dika E, Perrot JL, Rubegni P
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1874-1878. Epub 2018 Jun 26 doi: 10.1111/jdv.15108. PMID: 29869357
The Diagnosis and Treatment of Nail Disorders.
Wollina U, Nenoff P, Haroske G, Haenssle HA
Dtsch Arztebl Int 2016 Jul 25;113(29-30):509-18. doi: 10.3238/arztebl.2016.0509. PMID: 27545710Free PMC Article

Diagnosis

Side effects of gel nail polish: A systematic review.
Litaiem N, Baklouti M, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):706-715. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.008. PMID: 35907576
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Nail neoplasms.
Park JH, Lee DY, Kim N
J Dermatol 2017 Mar;44(3):279-287. doi: 10.1111/1346-8138.13702. PMID: 28256766
Nail histopathology.
Martin B
Actas Dermosifiliogr 2013 Sep;104(7):564-78. Epub 2013 Jul 17 doi: 10.1016/j.adengl.2013.06.001. PMID: 23871460

Therapy

Side effects of gel nail polish: A systematic review.
Litaiem N, Baklouti M, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):706-715. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.008. PMID: 35907576
Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Selenium and cancer risk: Wide-angled Mendelian randomization analysis.
Yuan S, Mason AM, Carter P, Vithayathil M, Kar S, Burgess S, Larsson SC
Int J Cancer 2022 Apr 1;150(7):1134-1140. Epub 2021 Dec 24 doi: 10.1002/ijc.33902. PMID: 34910310Free PMC Article
Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors.
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article

Prognosis

Selenium and cancer risk: Wide-angled Mendelian randomization analysis.
Yuan S, Mason AM, Carter P, Vithayathil M, Kar S, Burgess S, Larsson SC
Int J Cancer 2022 Apr 1;150(7):1134-1140. Epub 2021 Dec 24 doi: 10.1002/ijc.33902. PMID: 34910310Free PMC Article
Subungual Melanoma.
Littleton TW, Murray PM, Baratz ME
Orthop Clin North Am 2019 Jul;50(3):357-366. doi: 10.1016/j.ocl.2019.03.003. PMID: 31084838
Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial-FIRSTANA.
Oudard S, Fizazi K, Sengeløv L, Daugaard G, Saad F, Hansen S, Hjälm-Eriksson M, Jassem J, Thiery-Vuillemin A, Caffo O, Castellano D, Mainwaring PN, Bernard J, Shen L, Chadjaa M, Sartor O
J Clin Oncol 2017 Oct 1;35(28):3189-3197. Epub 2017 Jul 28 doi: 10.1200/JCO.2016.72.1068. PMID: 28753384
Acral Lentiginous Melanoma.
Goydos JS, Shoen SL
Cancer Treat Res 2016;167:321-9. doi: 10.1007/978-3-319-22539-5_14. PMID: 26601870
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590

Clinical prediction guides

Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Selenium and cancer risk: Wide-angled Mendelian randomization analysis.
Yuan S, Mason AM, Carter P, Vithayathil M, Kar S, Burgess S, Larsson SC
Int J Cancer 2022 Apr 1;150(7):1134-1140. Epub 2021 Dec 24 doi: 10.1002/ijc.33902. PMID: 34910310Free PMC Article
Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors.
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Onychoscopy.
Lencastre A, Lamas A, Sá D, Tosti A
Clin Dermatol 2013 Sep-Oct;31(5):587-93. doi: 10.1016/j.clindermatol.2013.06.016. PMID: 24079588

Recent systematic reviews

Metastases to the nail unit and distal phalanx: a systematic review.
Curtis KL, Lipner SR
Arch Dermatol Res 2023 Apr;315(3):347-358. Epub 2022 Oct 19 doi: 10.1007/s00403-022-02411-6. PMID: 36260150
Side effects of gel nail polish: A systematic review.
Litaiem N, Baklouti M, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):706-715. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.008. PMID: 35907576
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Melanoma of the nail apparatus: a systematic review and meta-analysis of current challenges and prognosis.
Lieberherr S, Cazzaniga S, Haneke E, Hunger RE, Seyed Jafari SM
J Eur Acad Dermatol Venereol 2020 May;34(5):967-976. Epub 2020 Jan 6 doi: 10.1111/jdv.16121. PMID: 31788861
The association between Selenium and Prostate Cancer: a Systematic Review and Meta-Analysis.
Sayehmiri K, Azami M, Mohammadi Y, Soleymani A, Tardeh Z
Asian Pac J Cancer Prev 2018 Jun 25;19(6):1431-1437. doi: 10.22034/APJCP.2018.19.6.1431. PMID: 29936712Free PMC Article

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