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Abnormal microglia morphology

MedGen UID:
867604
•Concept ID:
C4021990
•
Finding
Synonym: Abnormality of the microglia
 
HPO: HP:0100708

Definition

An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal microglia morphology

Professional guidelines

PubMed

Neurovascular Unit Alterations in the Growth-Restricted Newborn Are Improved Following Ibuprofen Treatment.
Chand KK, Miller SM, Cowin GJ, Mohanty L, Pienaar J, Colditz PB, Bjorkman ST, Wixey JA
Mol Neurobiol 2022 Feb;59(2):1018-1040. Epub 2021 Nov 26 doi: 10.1007/s12035-021-02654-w. PMID: 34825315
Treatment of CSF1R-Related Leukoencephalopathy: Breaking New Ground.
Tipton PW, Kenney-Jung D, Rush BK, Middlebrooks EH, Nascene D, Singh B, Holtan S, Ayala E, Broderick DF, Lund T, Wszolek ZK
Mov Disord 2021 Dec;36(12):2901-2909. Epub 2021 Jul 30 doi: 10.1002/mds.28734. PMID: 34329526
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article

Recent clinical studies

Etiology

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P
Cell Stem Cell 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230Free PMC Article
Primary Microglia Dysfunction or Microgliopathy: A Cause of Dementias and Other Neurological or Psychiatric Disorders.
Bianchin MM, Snow Z
Neuroscience 2022 Aug 10;497:324-339. Epub 2022 Jun 24 doi: 10.1016/j.neuroscience.2022.06.032. PMID: 35760218
Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome.
Correa-da-Silva F, Fliers E, Swaab DF, Yi CX
J Neuroendocrinol 2021 Jul;33(7):e12994. Epub 2021 Jun 22 doi: 10.1111/jne.12994. PMID: 34156126Free PMC Article
Alzheimer's Disease Research Using Human Microglia.
Lue LF, Beach TG, Walker DG
Cells 2019 Aug 5;8(8) doi: 10.3390/cells8080838. PMID: 31387311Free PMC Article
Intersection of pathological tau and microglia at the synapse.
Vogels T, Murgoci AN, Hromádka T
Acta Neuropathol Commun 2019 Jul 5;7(1):109. doi: 10.1186/s40478-019-0754-y. PMID: 31277708Free PMC Article

Diagnosis

Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review.
Park JC, Han SH, Mook-Jung I
BMB Rep 2020 Jan;53(1):10-19. doi: 10.5483/BMBRep.2020.53.1.309. PMID: 31865964Free PMC Article
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.
Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901Free PMC Article
The neuropathology of chronic traumatic encephalopathy.
Mckee AC, Abdolmohammadi B, Stein TD
Handb Clin Neurol 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8. PMID: 30482357
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693
Neuropathogenesis of human immunodeficiency virus infection.
Sillman B, Woldstad C, Mcmillan J, Gendelman HE
Handb Clin Neurol 2018;152:21-40. doi: 10.1016/B978-0-444-63849-6.00003-7. PMID: 29604978

Therapy

Alzheimer disease neuropathology in a patient previously treated with aducanumab.
Plowey ED, Bussiere T, Rajagovindan R, Sebalusky J, Hamann S, von Hehn C, Castrillo-Viguera C, Sandrock A, Budd Haeberlein S, van Dyck CH, Huttner A
Acta Neuropathol 2022 Jul;144(1):143-153. Epub 2022 May 17 doi: 10.1007/s00401-022-02433-4. PMID: 35581440Free PMC Article
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
J Neuroinflammation 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706Free PMC Article
Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Neuroinflammation in L-DOPA-induced dyskinesia: beyond the immune function.
Pisanu A, Boi L, Mulas G, Spiga S, Fenu S, Carta AR
J Neural Transm (Vienna) 2018 Aug;125(8):1287-1297. Epub 2018 Mar 14 doi: 10.1007/s00702-018-1874-4. PMID: 29541852

Prognosis

Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer's Disease.
Huang W, Xia Q, Zheng F, Zhao X, Ge F, Xiao J, Liu Z, Shen Y, Ye K, Wang D, Li Y
J Alzheimers Dis 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064. PMID: 36683511Free PMC Article
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations-A Short Overview.
Timis TL, Florian IA, Susman S, Florian IS
Int J Mol Sci 2021 Jun 7;22(11) doi: 10.3390/ijms22116141. PMID: 34200256Free PMC Article
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693
Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain.
Astell KR, Sieger D
Methods Cell Biol 2017;138:593-626. Epub 2016 Oct 31 doi: 10.1016/bs.mcb.2016.10.001. PMID: 28129859

Clinical prediction guides

Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Microglia in animal models of autism spectrum disorders.
Andoh M, Ikegaya Y, Koyama R
Prog Mol Biol Transl Sci 2020;173:239-273. Epub 2020 May 8 doi: 10.1016/bs.pmbts.2020.04.012. PMID: 32711812
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.
Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, Cui M, Tieu K
Brain 2020 May 1;143(5):1476-1497. doi: 10.1093/brain/awaa090. PMID: 32355963Free PMC Article
Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Haukedal H, Freude K
J Mol Biol 2019 Apr 19;431(9):1818-1829. Epub 2019 Feb 11 doi: 10.1016/j.jmb.2019.02.004. PMID: 30763568
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Recent systematic reviews

Brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS): new cases, systematic literature review, and associations with CSF1R-ALSP.
Dulski J, Souza J, Santos ML, Wszolek ZK
Orphanet J Rare Dis 2023 Jun 22;18(1):160. doi: 10.1186/s13023-023-02772-9. PMID: 37349768Free PMC Article
Sudden hearing loss as an early detector of multiple sclerosis: a systematic review.
Di Stadio A, Dipietro L, Ralli M, Meneghello F, Minni A, Greco A, Stabile MR, Bernitsas E
Eur Rev Med Pharmacol Sci 2018 Jul;22(14):4611-4624. doi: 10.26355/eurrev_201807_15520. PMID: 30058696
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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