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Abnormal oligodendroglia morphology

MedGen UID:
867606
•Concept ID:
C4021992
•
Finding
Synonym: Abnormality of the oligodendroglia
 
HPO: HP:0100706

Definition

One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal oligodendroglia morphology

Professional guidelines

PubMed

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity.
van Rensburg SJ, van Toorn R, Erasmus RT, Hattingh C, Johannes C, Moremi KE, Kemp MC, Engel-Hills P, Kotze MJ
Metab Brain Dis 2021 Aug;36(6):1151-1167. Epub 2021 Apr 28 doi: 10.1007/s11011-021-00711-w. PMID: 33909200
Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS).
KhorshidAhmad T, Acosta C, Cortes C, Lakowski TM, Gangadaran S, Namaka M
Mol Neurobiol 2016 Mar;53(2):1092-1107. Epub 2015 Jan 13 doi: 10.1007/s12035-014-9074-1. PMID: 25579386
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article

Recent clinical studies

Etiology

Pelizaeus-Merzbacher Disease: Molecular and Cellular Pathologies and Associated Phenotypes.
Inoue K
Adv Exp Med Biol 2019;1190:201-216. doi: 10.1007/978-981-32-9636-7_13. PMID: 31760646
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes.
Nasrabady SE, Rizvi B, Goldman JE, Brickman AM
Acta Neuropathol Commun 2018 Mar 2;6(1):22. doi: 10.1186/s40478-018-0515-3. PMID: 29499767Free PMC Article
Neuropathological spectrum of synucleinopathies.
Jellinger KA
Mov Disord 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. PMID: 14502650
Paraproteinemic neuropathies.
Vital A
Brain Pathol 2001 Oct;11(4):399-407. doi: 10.1111/j.1750-3639.2001.tb00407.x. PMID: 11556684Free PMC Article

Diagnosis

Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration.
Jellinger KA
J Neural Transm (Vienna) 2023 Dec;130(12):1509-1522. Epub 2023 Sep 2 doi: 10.1007/s00702-023-02691-w. PMID: 37659990
Myelin water imaging to detect demyelination and remyelination and its validation in pathology.
Laule C, Moore GRW
Brain Pathol 2018 Sep;28(5):750-764. doi: 10.1111/bpa.12645. PMID: 30375119Free PMC Article
Neuropathological spectrum of synucleinopathies.
Jellinger KA
Mov Disord 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. PMID: 14502650
Pelizaeus-Merzbacher disease.
Koeppen AH, Robitaille Y
J Neuropathol Exp Neurol 2002 Sep;61(9):747-59. doi: 10.1093/jnen/61.9.747. PMID: 12230321
Imaging of remyelination.
Barkhof F
Mult Scler 1997 Apr;3(2):129-32. doi: 10.1177/135245859700300212. PMID: 9291166

Therapy

Abnormal oligodendrocyte function in schizophrenia explains the long latent interval in some patients.
Fessel J
Transl Psychiatry 2022 Mar 25;12(1):120. doi: 10.1038/s41398-022-01879-0. PMID: 35338111Free PMC Article
Drug-Induced Demyelinating Neuropathies.
Niimi N, Takaku S, Yako H, Sango K
Adv Exp Med Biol 2019;1190:357-369. doi: 10.1007/978-981-32-9636-7_23. PMID: 31760656
The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis.
Choi BY, Jung JW, Suh SW
Int J Mol Sci 2017 Sep 28;18(10) doi: 10.3390/ijms18102070. PMID: 28956834Free PMC Article
Novel therapeutic approaches in multiple system atrophy.
Palma JA, Kaufmann H
Clin Auton Res 2015 Feb;25(1):37-45. Epub 2014 Jun 14 doi: 10.1007/s10286-014-0249-7. PMID: 24928797Free PMC Article
Non-vision adverse events with vigabatrin therapy.
Walker SD, Kälviäinen R
Acta Neurol Scand Suppl 2011;(192):72-82. doi: 10.1111/j.1600-0404.2011.01602.x. PMID: 22061182

Prognosis

Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain.
Darbinian N, Darbinyan A, Merabova N, Bajwa A, Tatevosian G, Martirosyan D, Zhao H, Selzer ME, Goetzl L
Neurobiol Dis 2021 Jan;148:105181. Epub 2020 Nov 13 doi: 10.1016/j.nbd.2020.105181. PMID: 33189883Free PMC Article
Nodopathies of the peripheral nerve: an emerging concept.
Uncini A, Kuwabara S
J Neurol Neurosurg Psychiatry 2015 Nov;86(11):1186-95. Epub 2015 Feb 19 doi: 10.1136/jnnp-2014-310097. PMID: 25699569
Cytokines and myelination in the central nervous system.
Schmitz T, Chew LJ
ScientificWorldJournal 2008 Nov 2;8:1119-47. doi: 10.1100/tsw.2008.140. PMID: 18979053Free PMC Article
Common themes in peripheral neuropathy disease genes.
Snipes GJ, Orfali W
Cell Biol Int 1998 Nov;22(11-12):815-35. doi: 10.1006/cbir.1998.0389. PMID: 10873294
Multiple sclerosis: neuroimmunologic puzzle.
Barna BP
Clin Lab Med 1986 Mar;6(1):103-16. doi: 10.1016/S0272-2712(18)30828-X. PMID: 3514094Free PMC Article

Clinical prediction guides

Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis.
Traiffort E, Morisset-Lopez S, Moussaed M, Zahaf A
Int J Mol Sci 2021 Mar 26;22(7) doi: 10.3390/ijms22073426. PMID: 33810425Free PMC Article
Central nervous system diseases related to pathological microglial phagocytosis.
Wang K, Li J, Zhang Y, Huang Y, Chen D, Shi Z, Smith AD, Li W, Gao Y
CNS Neurosci Ther 2021 May;27(5):528-539. Epub 2021 Mar 2 doi: 10.1111/cns.13619. PMID: 33650762Free PMC Article
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.
Kaindlstorfer C, Jellinger KA, Eschlböck S, Stefanova N, Weiss G, Wenning GK
J Alzheimers Dis 2018;61(4):1253-1273. doi: 10.3233/JAD-170601. PMID: 29376857Free PMC Article
The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis.
Choi BY, Jung JW, Suh SW
Int J Mol Sci 2017 Sep 28;18(10) doi: 10.3390/ijms18102070. PMID: 28956834Free PMC Article
Neurobiology of premature brain injury.
Salmaso N, Jablonska B, Scafidi J, Vaccarino FM, Gallo V
Nat Neurosci 2014 Mar;17(3):341-6. Epub 2014 Feb 25 doi: 10.1038/nn.3604. PMID: 24569830Free PMC Article

Recent systematic reviews

Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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