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Abnormal substantia nigra morphology

MedGen UID:
868012
•Concept ID:
C4022403
•
Anatomical Abnormality
Synonym: Abnormality of the substantia nigra
 
HPO: HP:0045007

Definition

A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. [from HPO]

Professional guidelines

PubMed

Technological prospection: patents mapping involving compounds for the treatment of L-DOPA-induced dyskinesias.
Barroso SDS, Lopes LES, Santos KS, Gomes MZ
Expert Opin Ther Pat 2019 Dec;29(12):979-985. Epub 2019 Nov 13 doi: 10.1080/13543776.2019.1690453. PMID: 31694421
Critical involvement of the motor cortex in the pathophysiology and treatment of Parkinson's disease.
Lindenbach D, Bishop C
Neurosci Biobehav Rev 2013 Dec;37(10 Pt 2):2737-50. Epub 2013 Oct 7 doi: 10.1016/j.neubiorev.2013.09.008. PMID: 24113323Free PMC Article
Progressive supranuclear palsy: clinical features, pathophysiology and management.
Rajput A, Rajput AH
Drugs Aging 2001;18(12):913-25. doi: 10.2165/00002512-200118120-00003. PMID: 11888346

Recent clinical studies

Etiology

Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.
Todd G, Pearson-Dennett V, Wilcox RA, Chau MT, Thoirs K, Thewlis D, Vogel AP, White JM
Parkinsonism Relat Disord 2016 Apr;25:27-32. Epub 2016 Feb 21 doi: 10.1016/j.parkreldis.2016.02.019. PMID: 26923520
Hand function is impaired in healthy older adults at risk of Parkinson's disease.
Todd G, Haberfield M, Faulkner PL, Rae C, Hayes M, Wilcox RA, Taylor JL, Gandevia SC, Godau J, Berg D, Piguet O, Double KL
J Neural Transm (Vienna) 2014 Nov;121(11):1377-86. Epub 2014 May 3 doi: 10.1007/s00702-014-1218-y. PMID: 24793059
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans.
Todd G, Noyes C, Flavel SC, Della Vedova CB, Spyropoulos P, Chatterton B, Berg D, White JM
PLoS One 2013;8(2):e56438. Epub 2013 Feb 13 doi: 10.1371/journal.pone.0056438. PMID: 23418568Free PMC Article

Therapy

Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.
Todd G, Pearson-Dennett V, Wilcox RA, Chau MT, Thoirs K, Thewlis D, Vogel AP, White JM
Parkinsonism Relat Disord 2016 Apr;25:27-32. Epub 2016 Feb 21 doi: 10.1016/j.parkreldis.2016.02.019. PMID: 26923520
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans.
Todd G, Noyes C, Flavel SC, Della Vedova CB, Spyropoulos P, Chatterton B, Berg D, White JM
PLoS One 2013;8(2):e56438. Epub 2013 Feb 13 doi: 10.1371/journal.pone.0056438. PMID: 23418568Free PMC Article

Clinical prediction guides

Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.
Todd G, Pearson-Dennett V, Wilcox RA, Chau MT, Thoirs K, Thewlis D, Vogel AP, White JM
Parkinsonism Relat Disord 2016 Apr;25:27-32. Epub 2016 Feb 21 doi: 10.1016/j.parkreldis.2016.02.019. PMID: 26923520
Hand function is impaired in healthy older adults at risk of Parkinson's disease.
Todd G, Haberfield M, Faulkner PL, Rae C, Hayes M, Wilcox RA, Taylor JL, Gandevia SC, Godau J, Berg D, Piguet O, Double KL
J Neural Transm (Vienna) 2014 Nov;121(11):1377-86. Epub 2014 May 3 doi: 10.1007/s00702-014-1218-y. PMID: 24793059
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans.
Todd G, Noyes C, Flavel SC, Della Vedova CB, Spyropoulos P, Chatterton B, Berg D, White JM
PLoS One 2013;8(2):e56438. Epub 2013 Feb 13 doi: 10.1371/journal.pone.0056438. PMID: 23418568Free PMC Article

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