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Abnormal pineal morphology

MedGen UID:
868388
•Concept ID:
C4022782
•
Anatomical Abnormality
Synonym: Abnormality of pineal morphology
 
HPO: HP:0012681

Definition

A structural abnormality of the pineal gland. [from HPO]

Professional guidelines

PubMed

Neuroendoscopy in the management of pineal region tumours in children.
Deopujari C, Shroff K, Karmarkar V, Mohanty C
Childs Nerv Syst 2023 Sep;39(9):2353-2365. Epub 2022 Jun 3 doi: 10.1007/s00381-022-05561-0. PMID: 35665837
Clinical management of pineal cysts: a worldwide online survey.
Májovský M, Netuka D, Beneš V
Acta Neurochir (Wien) 2016 Apr;158(4):663-669. Epub 2016 Feb 20 doi: 10.1007/s00701-016-2726-3. PMID: 26897024
Masses and malformations of the third ventricle: normal anatomic relationships and differential diagnoses.
Glastonbury CM, Osborn AG, Salzman KL
Radiographics 2011 Nov-Dec;31(7):1889-905. doi: 10.1148/rg.317115083. PMID: 22084178

Recent clinical studies

Etiology

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Potential contribution of pineal atrophy and pineal cysts toward vulnerability and clinical characteristics of psychosis.
Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
Neuroimage Clin 2021;32:102805. Epub 2021 Aug 25 doi: 10.1016/j.nicl.2021.102805. PMID: 34461434Free PMC Article
Incidental Intracranial Cysts in Children.
Muhlestein WE, Maher CO
Pediatr Clin North Am 2021 Aug;68(4):775-782. doi: 10.1016/j.pcl.2021.04.005. PMID: 34247708
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531
The pineal gland from development to function.
Sapède D, Cau E
Curr Top Dev Biol 2013;106:171-215. doi: 10.1016/B978-0-12-416021-7.00005-5. PMID: 24290350

Diagnosis

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Incidental Intracranial Cysts in Children.
Muhlestein WE, Maher CO
Pediatr Clin North Am 2021 Aug;68(4):775-782. doi: 10.1016/j.pcl.2021.04.005. PMID: 34247708
Pineal region masses--imaging findings and surgical approaches.
Lensing FD, Abele TA, Sivakumar W, Taussky P, Shah LM, Salzman KL
Curr Probl Diagn Radiol 2015 Jan-Feb;44(1):76-87. Epub 2014 Jul 11 doi: 10.1067/j.cpradiol.2014.05.007. PMID: 25027864
Familial pineocytoma.
Gempt J, Ringel F, Oexle K, Delbridge C, Förschler A, Schlegel J, Meyer B, Schmidt-Graf F
Acta Neurochir (Wien) 2012 Aug;154(8):1413-6. Epub 2012 Jun 15 doi: 10.1007/s00701-012-1402-5. PMID: 22699425
Wilson disease.
Kitzberger R, Madl C, Ferenci P
Metab Brain Dis 2005 Dec;20(4):295-302. doi: 10.1007/s11011-005-7910-8. PMID: 16382340

Therapy

Intracranial cysts: incidental or neurodevelopmental?
Dirik MA, Sanlidag B
Childs Nerv Syst 2023 Mar;39(3):775-780. Epub 2022 Nov 2 doi: 10.1007/s00381-022-05724-z. PMID: 36323954
Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience.
Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice.
Liu Y, Weng X, Wei M, Yu S, Ding Y, Cheng B
Biochem Pharmacol 2022 Jul;201:115073. Epub 2022 May 4 doi: 10.1016/j.bcp.2022.115073. PMID: 35525327
Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology.
Hossain MF, Uddin MS, Uddin GMS, Sumsuzzman DM, Islam MS, Barreto GE, Mathew B, Ashraf GM
Mol Neurobiol 2019 Dec;56(12):8255-8276. Epub 2019 Jun 17 doi: 10.1007/s12035-019-01660-3. PMID: 31209782
Abnormal EEG and calcification of the pineal gland in schizophrenia.
Sandyk R, Kay SR
Int J Neurosci 1992 Jan;62(1-2):107-11. doi: 10.3109/00207459108999764. PMID: 1342008

Prognosis

Pineal cysts: Does anyone need long-term follow up?
Tanaka T, Arnold L, Gabriela Mazuru D, Golzy M, Carr SB, Litofsky NS
J Clin Neurosci 2021 Jan;83:146-151. Epub 2020 Nov 30 doi: 10.1016/j.jocn.2020.10.051. PMID: 33272885
Reduced pineal gland volume across the stages of schizophrenia.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M
Schizophr Res 2019 Apr;206:163-170. Epub 2018 Dec 5 doi: 10.1016/j.schres.2018.11.032. PMID: 30527931
Pediatric central nervous system germ cell tumors: a review.
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924
Primary retroperitoneal teratomas: a review of the literature.
Gatcombe HG, Assikis V, Kooby D, Johnstone PA
J Surg Oncol 2004 May 1;86(2):107-13. doi: 10.1002/jso.20043. PMID: 15112254
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Clinical prediction guides

Intracranial cysts: incidental or neurodevelopmental?
Dirik MA, Sanlidag B
Childs Nerv Syst 2023 Mar;39(3):775-780. Epub 2022 Nov 2 doi: 10.1007/s00381-022-05724-z. PMID: 36323954
Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Potential contribution of pineal atrophy and pineal cysts toward vulnerability and clinical characteristics of psychosis.
Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
Neuroimage Clin 2021;32:102805. Epub 2021 Aug 25 doi: 10.1016/j.nicl.2021.102805. PMID: 34461434Free PMC Article
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531
Normal neuroanatomical variants that may be misinterpreted as disease entities.
Ramji S, Touska P, Rich P, MacKinnon AD
Clin Radiol 2017 Oct;72(10):810-825. Epub 2017 Jul 23 doi: 10.1016/j.crad.2017.06.118. PMID: 28747250

Recent systematic reviews

Papillary tumor of the pineal region in pediatric populations: An additional case and systematic review of a rare tumor entity.
Mathkour M, Hanna J, Ibrahim N, Scullen T, Kilgore MD, Werner C, Cormier I, Spencer P, Keen JR, Bui CJ
Clin Neurol Neurosurg 2021 Feb;201:106404. Epub 2020 Dec 8 doi: 10.1016/j.clineuro.2020.106404. PMID: 33360024

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