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Abnormal brain positron emission tomography

MedGen UID:
868405
Concept ID:
C4022799
Anatomical Abnormality
Synonym: Abnormal brain PET scan
 
HPO: HP:0012657

Definition

A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain. [from HPO]

Professional guidelines

PubMed

Cummings J, Osse AML, Cammann D, Powell J, Chen J
BioDrugs 2024 Jan;38(1):5-22. Epub 2023 Nov 13 doi: 10.1007/s40259-023-00633-2. PMID: 37955845Free PMC Article
Wu W, Ji Y, Wang Z, Wu X, Li J, Gu F, Chen Z, Wang Z
Eur J Med Res 2023 Nov 28;28(1):544. doi: 10.1186/s40001-023-01512-w. PMID: 38017568Free PMC Article
Rahman A, Hossen MA, Chowdhury MFI, Bari S, Tamanna N, Sultana SS, Haque SN, Al Masud A, Saif-Ur-Rahman KM
Psychogeriatrics 2023 May;23(3):512-522. Epub 2023 Feb 12 doi: 10.1111/psyg.12944. PMID: 36775284

Recent clinical studies

Etiology

Coughlan GT, Betthauser TJ, Boyle R, Koscik RL, Klinger HM, Chibnik LB, Jonaitis EM, Yau WW, Wenzel A, Christian BT, Gleason CE, Saelzler UG, Properzi MJ, Schultz AP, Hanseeuw BJ, Manson JE, Rentz DM, Johnson KA, Sperling R, Johnson SC, Buckley RF
JAMA Neurol 2023 May 1;80(5):462-473. doi: 10.1001/jamaneurol.2023.0455. PMID: 37010830Free PMC Article
Ferrucci R, Cuffaro L, Capozza A, Rosci C, Maiorana N, Groppo E, Reitano MR, Poletti B, Ticozzi N, Tagliabue L, Silani V, Priori A
J Neurol 2023 Apr;270(4):1823-1834. Epub 2023 Jan 24 doi: 10.1007/s00415-022-11543-8. PMID: 36692636Free PMC Article
Ossenkoppele R, Pichet Binette A, Groot C, Smith R, Strandberg O, Palmqvist S, Stomrud E, Tideman P, Ohlsson T, Jögi J, Johnson K, Sperling R, Dore V, Masters CL, Rowe C, Visser D, van Berckel BNM, van der Flier WM, Baker S, Jagust WJ, Wiste HJ, Petersen RC, Jack CR Jr, Hansson O
Nat Med 2022 Nov;28(11):2381-2387. Epub 2022 Nov 10 doi: 10.1038/s41591-022-02049-x. PMID: 36357681Free PMC Article
Horsager J, Andersen KB, Knudsen K, Skjærbæk C, Fedorova TD, Okkels N, Schaeffer E, Bonkat SK, Geday J, Otto M, Sommerauer M, Danielsen EH, Bech E, Kraft J, Munk OL, Hansen SD, Pavese N, Göder R, Brooks DJ, Berg D, Borghammer P
Brain 2020 Oct 1;143(10):3077-3088. doi: 10.1093/brain/awaa238. PMID: 32830221
Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164Free PMC Article

Diagnosis

Ko JH, Strafella AP
Handb Clin Neurol 2022;184:121-132. doi: 10.1016/B978-0-12-819410-2.00006-0. PMID: 35034729
Horsager J, Andersen KB, Knudsen K, Skjærbæk C, Fedorova TD, Okkels N, Schaeffer E, Bonkat SK, Geday J, Otto M, Sommerauer M, Danielsen EH, Bech E, Kraft J, Munk OL, Hansen SD, Pavese N, Göder R, Brooks DJ, Berg D, Borghammer P
Brain 2020 Oct 1;143(10):3077-3088. doi: 10.1093/brain/awaa238. PMID: 32830221
Albajara Sáenz A, Villemonteix T, Massat I
Dev Med Child Neurol 2019 Apr;61(4):399-405. Epub 2018 Oct 1 doi: 10.1111/dmcn.14050. PMID: 30276811
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693
Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164Free PMC Article

Therapy

Yadollahikhales G, Rojas JC
Neurotherapeutics 2023 Jul;20(4):914-931. Epub 2023 Jul 25 doi: 10.1007/s13311-023-01405-0. PMID: 37490245Free PMC Article
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
Sperling RA, Donohue MC, Raman R, Rafii MS, Johnson K, Masters CL, van Dyck CH, Iwatsubo T, Marshall GA, Yaari R, Mancini M, Holdridge KC, Case M, Sims JR, Aisen PS; A4 Study Team
N Engl J Med 2023 Sep 21;389(12):1096-1107. Epub 2023 Jul 17 doi: 10.1056/NEJMoa2305032. PMID: 37458272Free PMC Article
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, Froelich L, Katayama S, Sabbagh M, Vellas B, Watson D, Dhadda S, Irizarry M, Kramer LD, Iwatsubo T
N Engl J Med 2023 Jan 5;388(1):9-21. Epub 2022 Nov 29 doi: 10.1056/NEJMoa2212948. PMID: 36449413
Swanson CJ, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai RYK, Lannfelt L, Bradley H, Rabe M, Koyama A, Reyderman L, Berry DA, Berry S, Gordon R, Kramer LD, Cummings JL
Alzheimers Res Ther 2021 Apr 17;13(1):80. doi: 10.1186/s13195-021-00813-8. PMID: 33865446Free PMC Article

Prognosis

Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC
Nat Med 2022 Jul;28(7):1398-1405. Epub 2022 May 26 doi: 10.1038/s41591-022-01822-2. PMID: 35618838Free PMC Article
Ko JH, Strafella AP
Handb Clin Neurol 2022;184:121-132. doi: 10.1016/B978-0-12-819410-2.00006-0. PMID: 35034729
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Clinical prediction guides

Coughlan GT, Betthauser TJ, Boyle R, Koscik RL, Klinger HM, Chibnik LB, Jonaitis EM, Yau WW, Wenzel A, Christian BT, Gleason CE, Saelzler UG, Properzi MJ, Schultz AP, Hanseeuw BJ, Manson JE, Rentz DM, Johnson KA, Sperling R, Johnson SC, Buckley RF
JAMA Neurol 2023 May 1;80(5):462-473. doi: 10.1001/jamaneurol.2023.0455. PMID: 37010830Free PMC Article
Li G, Liu X, Yu T, Ren J, Wang Q
Acta Neurol Scand 2022 Dec;146(6):708-715. Epub 2022 Oct 19 doi: 10.1111/ane.13717. PMID: 36259555
Ko JH, Strafella AP
Handb Clin Neurol 2022;184:121-132. doi: 10.1016/B978-0-12-819410-2.00006-0. PMID: 35034729
Bidesi NSR, Vang Andersen I, Windhorst AD, Shalgunov V, Herth MM
J Neurochem 2021 Nov;159(4):660-689. Epub 2021 Oct 3 doi: 10.1111/jnc.15516. PMID: 34532856Free PMC Article
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Recent systematic reviews

Wu W, Ji Y, Wang Z, Wu X, Li J, Gu F, Chen Z, Wang Z
Eur J Med Res 2023 Nov 28;28(1):544. doi: 10.1186/s40001-023-01512-w. PMID: 38017568Free PMC Article
Xu H, Owens MM, Farncombe T, Noseworthy M, MacKillop J
J Psychiatr Res 2023 Jun;162:44-56. Epub 2023 Apr 11 doi: 10.1016/j.jpsychires.2023.03.045. PMID: 37088043
Rahman A, Hossen MA, Chowdhury MFI, Bari S, Tamanna N, Sultana SS, Haque SN, Al Masud A, Saif-Ur-Rahman KM
Psychogeriatrics 2023 May;23(3):512-522. Epub 2023 Feb 12 doi: 10.1111/psyg.12944. PMID: 36775284
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Bühler M, Mann K
Alcohol Clin Exp Res 2011 Oct;35(10):1771-93. Epub 2011 Jul 20 doi: 10.1111/j.1530-0277.2011.01540.x. PMID: 21777260

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