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Abnormal inflammatory response

MedGen UID:
868411
•Concept ID:
C4022805
•
Pathologic Function
HPO: HP:0012647

Definition

Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal inflammatory response

Professional guidelines

PubMed

COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S
Cochrane Database Syst Rev 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2. PMID: 30480772Free PMC Article

Recent clinical studies

Etiology

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.
Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W
J Pathol 2020 Apr;250(5):624-635. Epub 2019 Dec 3 doi: 10.1002/path.5364. PMID: 31691283Free PMC Article
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S
Cochrane Database Syst Rev 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2. PMID: 30480772Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article
Copd.
Kerstjens HA, Postma DS, Ten Hacken N
BMJ Clin Evid 2008 Dec 15;2008 PMID: 19445783Free PMC Article

Diagnosis

COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
Pediatric sarcoidosis with diagnostic and therapeutical insights.
Sergi CM
Curr Opin Pulm Med 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614
Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions.
Naramore S, Gupta SK
J Pediatr Gastroenterol Nutr 2018 Sep;67(3):318-321. doi: 10.1097/MPG.0000000000002040. PMID: 29851758Free PMC Article
Biomarkers in COPD.
Tzortzaki EG, Lambiri I, Vlachaki E, Siafakas NM
Curr Med Chem 2007;14(9):1037-48. doi: 10.2174/092986707780362943. PMID: 17439401

Therapy

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases.
Battistini C, Ballan R, Herkenhoff ME, Saad SMI, Sun J
Int J Mol Sci 2020 Dec 31;22(1) doi: 10.3390/ijms22010362. PMID: 33396382Free PMC Article
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.
Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W
J Pathol 2020 Apr;250(5):624-635. Epub 2019 Dec 3 doi: 10.1002/path.5364. PMID: 31691283Free PMC Article
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S
Cochrane Database Syst Rev 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2. PMID: 30480772Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article

Prognosis

CC16 as an Inflammatory Biomarker in Induced Sputum Reflects Chronic Obstructive Pulmonary Disease (COPD) Severity.
Chen M, Xu K, He Y, Jin J, Mao R, Gao L, Zhang Y, Wang G, Gao P, Xie M, Liu C, Chen Z
Int J Chron Obstruct Pulmon Dis 2023;18:705-717. Epub 2023 Apr 27 doi: 10.2147/COPD.S400999. PMID: 37139166Free PMC Article
Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
Mohibi S, Chen M, Chen X, Zhang J
Biochim Biophys Acta Mol Basis Dis 2023 Jan 1;1869(1):166587. Epub 2022 Oct 28 doi: 10.1016/j.bbadis.2022.166587. PMID: 36349645Free PMC Article
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
The Role of IgG4 in Autoimmunity and Rheumatic Diseases.
Maslinska M, Dmowska-Chalaba J, Jakubaszek M
Front Immunol 2021;12:787422. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.787422. PMID: 35145508Free PMC Article
Is there a role for antiinflammatory treatment in COPD?
Beeh KM, Glaab T
COPD 2009 Oct;6(5):395-403. doi: 10.1080/15412550903143901. PMID: 19863369

Clinical prediction guides

Pediatric sarcoidosis with diagnostic and therapeutical insights.
Sergi CM
Curr Opin Pulm Med 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614
Epidemiological and clinical aspects of Guillain-Barré syndrome and its variants.
Oliveira DRDCAB, Fernandez RNM, Grippe TC, Baião FS, Duarte RL, Fernandez DJ
Arq Neuropsiquiatr 2021 Jun;79(6):497-503. doi: 10.1590/0004-282X-ANP-2020-0314. PMID: 34320055Free PMC Article
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S
Cochrane Database Syst Rev 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2. PMID: 30480772Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article
Copd.
Kerstjens HA, Postma DS, Ten Hacken N
BMJ Clin Evid 2008 Dec 15;2008 PMID: 19445783Free PMC Article

Recent systematic reviews

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S
Cochrane Database Syst Rev 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2. PMID: 30480772Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article
Copd.
Kerstjens HA, Postma DS, Ten Hacken N
BMJ Clin Evid 2008 Dec 15;2008 PMID: 19445783Free PMC Article

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