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Abnormal number of erythroid precursors

MedGen UID:
868633
•Concept ID:
C4023033
•
Anatomical Abnormality
HPO: HP:0012131

Definition

A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. [from HPO]

Professional guidelines

PubMed

Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.
Fujiwara T, Okamoto K, Niikuni R, Takahashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Nakamura Y, Nakajima M, Tanaka T, Harigae H
Biochem Biophys Res Commun 2014 Nov 7;454(1):102-8. Epub 2014 Oct 18 doi: 10.1016/j.bbrc.2014.10.050. PMID: 25450364
Clinical potential for noninvasive prenatal diagnosis through detection of fetal cells in maternal blood.
Purwosunu Y, Sekizawa A, Koide K, Okazaki S, Farina A, Okai T
Taiwan J Obstet Gynecol 2006 Mar;45(1):10-20. doi: 10.1016/S1028-4559(09)60184-4. PMID: 17272202
Culture of fetal cells from maternal blood for prenatal diagnosis.
Elicha Gussin HA, Elias S
Hum Reprod Update 2002 Nov-Dec;8(6):523-7. doi: 10.1093/humupd/8.6.523. PMID: 12498422

Recent clinical studies

Etiology

Abnormalities of erythropoiesis during HIV-1 disease: a longitudinal analysis.
Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M
J Acquir Immune Defic Syndr 2009 Sep 1;52(1):70-4. doi: 10.1097/QAI.0b013e3181af65c5. PMID: 19574926
Perturbation of autocrine/paracrine loops of burst-forming units of erythroid-derived cells in rHuEPO-hyporesponsive hemodialysis patients.
Nakao K, Wada J, Ota K, Ichikawa H, Akagi S, Okamoto A, Hida K, Nagake Y, Makino H
Am J Kidney Dis 2003 Mar;41(3):624-36. doi: 10.1053/ajkd.2003.50124. PMID: 12612986
Human erythrocyte glycophorins: protein and gene structure analyses.
Cartron JP, Rahuel C
Transfus Med Rev 1992 Apr;6(2):63-92. doi: 10.1016/s0887-7963(92)70158-8. PMID: 1591491
Committed erythroid progenitors and erythropoietin levels in anemic children with lymphomas and tumors.
Kalmanti M, Kalmantis T
Pediatr Hematol Oncol 1989;6(2):85-93. doi: 10.3109/08880018909034274. PMID: 2702076
A study of erythroid progenitor cells in the bone marrow of Gambian children with falciparum malaria.
Abdalla SH, Wickramasinghe SN
Clin Lab Haematol 1988;10(1):33-40. doi: 10.1111/j.1365-2257.1988.tb01151.x. PMID: 3284694

Diagnosis

Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes.
Weidner H, Baschant U, Lademann F, Ledesma Colunga MG, Balaian E, Hofbauer C, Misof BM, Roschger P, Blouin S, Richards WG, Platzbecker U, Hofbauer LC, Rauner M
JCI Insight 2020 Aug 6;5(15) doi: 10.1172/jci.insight.137062. PMID: 32759495Free PMC Article
Update on anemia and neutropenia in copper deficiency.
Lazarchick J
Curr Opin Hematol 2012 Jan;19(1):58-60. doi: 10.1097/MOH.0b013e32834da9d2. PMID: 22080848
Clinical potential for noninvasive prenatal diagnosis through detection of fetal cells in maternal blood.
Purwosunu Y, Sekizawa A, Koide K, Okazaki S, Farina A, Okai T
Taiwan J Obstet Gynecol 2006 Mar;45(1):10-20. doi: 10.1016/S1028-4559(09)60184-4. PMID: 17272202
Diamond-Blackfan anemia: a congenital defect in erythropoiesis.
Dianzani I, Garelli E, Ramenghi U
Haematologica 1996 Nov-Dec;81(6):560-72. PMID: 9009445
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510

Therapy

PROGNOSIS OF THE COURSE OF CHORNOBYL-ORIGINATED ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN IN UKRAINE DEPENDING ON THE REASON OF STANDARD CHEMOTHERAPY INTERRUPTION.
Bebeshko VG, Bruslova KM, Tsvetkova NM, Lyashenko LO, Pushkariova TI, Gonchar LO, Tryhlib IV, Yatsemirskyi SM, Samson YM, Boyarskyi VG, Grischenko KV, Polyanska VM, Dmytrenko IV
Probl Radiac Med Radiobiol 2019 Dec;24:335-349. doi: 10.33145/2304-8336-2019-24-335-349. PMID: 31841478
Abnormalities of erythropoiesis during HIV-1 disease: a longitudinal analysis.
Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M
J Acquir Immune Defic Syndr 2009 Sep 1;52(1):70-4. doi: 10.1097/QAI.0b013e3181af65c5. PMID: 19574926
Perturbation of autocrine/paracrine loops of burst-forming units of erythroid-derived cells in rHuEPO-hyporesponsive hemodialysis patients.
Nakao K, Wada J, Ota K, Ichikawa H, Akagi S, Okamoto A, Hida K, Nagake Y, Makino H
Am J Kidney Dis 2003 Mar;41(3):624-36. doi: 10.1053/ajkd.2003.50124. PMID: 12612986
Abnormal kinetics of colony formation by erythroid burst-forming units (BFU-E) in chronic myeloid leukaemia.
Marley SB, Lewis JL, Goldman JM, Gordon MY
Br J Haematol 1996 Jun;93(4):878-83. doi: 10.1046/j.1365-2141.1996.d01-1738.x. PMID: 8703820
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510

Prognosis

PROGNOSIS OF THE COURSE OF CHORNOBYL-ORIGINATED ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN IN UKRAINE DEPENDING ON THE REASON OF STANDARD CHEMOTHERAPY INTERRUPTION.
Bebeshko VG, Bruslova KM, Tsvetkova NM, Lyashenko LO, Pushkariova TI, Gonchar LO, Tryhlib IV, Yatsemirskyi SM, Samson YM, Boyarskyi VG, Grischenko KV, Polyanska VM, Dmytrenko IV
Probl Radiac Med Radiobiol 2019 Dec;24:335-349. doi: 10.33145/2304-8336-2019-24-335-349. PMID: 31841478
Bone marrow cells from myelodysplastic syndromes show altered immunophenotypic profiles that may contribute to the diagnosis and prognostic stratification of the disease: a pilot study on a series of 56 patients.
Matarraz S, López A, Barrena S, Fernandez C, Jensen E, Flores-Montero J, Rasillo A, Sayagues JM, Sánchez ML, Bárcena P, Hernandez-Rivas JM, Salvador C, Fernandez-Mosteirín N, Giralt M, Perdiguer L, Laranjeira P, Paiva A, Orfao A
Cytometry B Clin Cytom 2010 May;78(3):154-68. doi: 10.1002/cyto.b.20513. PMID: 20198685
The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors.
Matarraz S, López A, Barrena S, Fernandez C, Jensen E, Flores J, Bárcena P, Rasillo A, Sayagues JM, Sánchez ML, Hernandez-Campo P, Hernandez Rivas JM, Salvador C, Fernandez-Mosteirín N, Giralt M, Perdiguer L, Orfao A
Leukemia 2008 Jun;22(6):1175-83. Epub 2008 Mar 13 doi: 10.1038/leu.2008.49. PMID: 18337765
Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates.
Murray NA, Roberts IA
Pediatr Res 1996 Jul;40(1):112-9. doi: 10.1203/00006450-199607000-00020. PMID: 8798256
Abnormal kinetics of colony formation by erythroid burst-forming units (BFU-E) in chronic myeloid leukaemia.
Marley SB, Lewis JL, Goldman JM, Gordon MY
Br J Haematol 1996 Jun;93(4):878-83. doi: 10.1046/j.1365-2141.1996.d01-1738.x. PMID: 8703820

Clinical prediction guides

Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors.
Youn M, Wang N, LaVasseur C, Bibikova E, Kam S, Glader B, Sakamoto KM, Narla A
Haematologica 2017 May;102(5):826-834. Epub 2017 Feb 2 doi: 10.3324/haematol.2016.156257. PMID: 28154085Free PMC Article
Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients.
Fibach E, Prus E, Bianchi N, Zuccato C, Breveglieri G, Salvatori F, Finotti A, Lipucci di Paola M, Brognara E, Lampronti I, Borgatti M, Gambari R
Int J Mol Med 2012 Jun;29(6):974-82. Epub 2012 Feb 28 doi: 10.3892/ijmm.2012.928. PMID: 22378234
Clinical potential for noninvasive prenatal diagnosis through detection of fetal cells in maternal blood.
Purwosunu Y, Sekizawa A, Koide K, Okazaki S, Farina A, Okai T
Taiwan J Obstet Gynecol 2006 Mar;45(1):10-20. doi: 10.1016/S1028-4559(09)60184-4. PMID: 17272202
Abnormal kinetics of colony formation by erythroid burst-forming units (BFU-E) in chronic myeloid leukaemia.
Marley SB, Lewis JL, Goldman JM, Gordon MY
Br J Haematol 1996 Jun;93(4):878-83. doi: 10.1046/j.1365-2141.1996.d01-1738.x. PMID: 8703820
Copper deficiency in humans.
Williams DM
Semin Hematol 1983 Apr;20(2):118-28. PMID: 6410510

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