U.S. flag

An official website of the United States government


Send to:

Choose Destination

Tibialis anterior muscle atrophy

MedGen UID:
Concept ID:
Synonym: Tibialis atrophy
HPO: HP:0011399


Wasting of the tibialis anterior muscle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTibialis anterior muscle atrophy

Conditions with this feature

Hereditary spastic paraplegia 55
MedGen UID:
Concept ID:
Disease or Syndrome
A rare complex type of hereditary spastic paraplegia with characteristics of childhood onset of progressive spastic paraplegia associated with optic atrophy (with reduced visual acuity and central scotoma), ophthalmoplegia, reduced upper-extremity strength and dexterity, muscular atrophy in the lower extremities and sensorimotor neuropathy. Caused by mutations in the C12ORF65 gene (12q24.31) encoding probable peptide chain release factor C12ORF65, mitochondrial.
MYH7-related skeletal myopathy
MedGen UID:
Concept ID:
Disease or Syndrome
Laing distal myopathy is characterized by early-onset weakness (usually before age 5 years) that initially involves the dorsiflexors of the ankles and great toes and then the finger extensors, especially those of the third and fourth fingers. Weakness of the neck flexors is seen in most affected individuals and mild facial weakness is often present. After distal weakness has been present for more than ten years, mild proximal weakness may be observed. Life expectancy is normal.

Professional guidelines


Cho MR, Lee S, Song SK
J Korean Med Sci 2022 May 9;37(18):e146. doi: 10.3346/jkms.2022.37.e146. PMID: 35535373Free PMC Article
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H
J Am Med Dir Assoc 2020 Mar;21(3):300-307.e2. Epub 2020 Feb 4 doi: 10.1016/j.jamda.2019.12.012. PMID: 32033882
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article

Recent clinical studies

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...