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Abnormal sixth cranial nerve morphology

MedGen UID:
868989
•Concept ID:
C4023404
•
Anatomical Abnormality
Synonyms: Abnormal abducens nerve morphology; Abnormality of the sixth cranial nerve
 
HPO: HP:0011348

Definition

Any structural abnormality of the abducens nerve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal sixth cranial nerve morphology

Professional guidelines

PubMed

Novel Segmentation of Placed Coils in the Treatment of Cavernous Sinus Dural Arteriovenous Fistulas Provides a Reliable Predictor of the Long-Term Outcome in Abducens Nerve Palsy.
Kohta M, Fujita A, Tanaka J, Sasayama T, Hosoda K, Kohmura E
World Neurosurg 2018 May;113:e38-e44. Epub 2018 Mar 7 doi: 10.1016/j.wneu.2018.01.136. PMID: 29408345
Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements.
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880
Gaucher disease--Norrbottnian type (III). Neuropaediatric and neurobiological aspects of clinical patterns and treatment.
Erikson A
Acta Paediatr Scand Suppl 1986;326:1-42. PMID: 3296644

Recent clinical studies

Etiology

Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Cranial nerve injuries in Le Fort I osteotomy: a systematic review.
Dos Santos Alves JM, de Freitas Alves BW, de Figueiredo Costa AC, Carneiro BGDS, de Sousa LM, Gondim DV
Int J Oral Maxillofac Surg 2019 May;48(5):601-611. Epub 2018 Dec 28 doi: 10.1016/j.ijom.2018.11.012. PMID: 30598335
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081
Nuclear and infranuclear disorders.
Meienberg O, Müri R
Baillieres Clin Neurol 1992 Aug;1(2):417-34. PMID: 1344077
Möbius and Möbius-like syndromes (TTV-OFM, OMLH).
Miller MT, Ray V, Owens P, Chen F
J Pediatr Ophthalmol Strabismus 1989 Jul-Aug;26(4):176-88. doi: 10.3928/0191-3913-19890701-07. PMID: 2668494

Diagnosis

Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Variable synergistic divergence.
Kim JH, Hwang JM
Optom Vis Sci 2009 Dec;86(12):1386-8. doi: 10.1097/OPX.0b013e3181be9db3. PMID: 19826317
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081
Möbius and Möbius-like syndromes (TTV-OFM, OMLH).
Miller MT, Ray V, Owens P, Chen F
J Pediatr Ophthalmol Strabismus 1989 Jul-Aug;26(4):176-88. doi: 10.3928/0191-3913-19890701-07. PMID: 2668494
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Therapy

Segmental Gracilis Muscle Transplantation for Midfacial Animation in Möbius Syndrome: A 29-Year Experience.
Roy M, Klar E, Ho ES, Zuker RM, Borschel GH
Plast Reconstr Surg 2019 Mar;143(3):581e-591e. doi: 10.1097/PRS.0000000000005368. PMID: 30817662
Posterior leukoencephalopathy syndrome in children and adolescents.
Alehan F, Erol I, Agildere AM, Ozcay F, Baskin E, Cengiz N, Alioglu B, Haberal M
J Child Neurol 2007 Apr;22(4):406-13. doi: 10.1177/0883073807301932. PMID: 17621519
Blindness as a complication of Le Fort I osteotomy for maxillary distraction.
Lo LJ, Hung KF, Chen YR
Plast Reconstr Surg 2002 Feb;109(2):688-98; discussion 699-700. doi: 10.1097/00006534-200202000-00041. PMID: 11818854
Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements.
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Prognosis

The Abducens Nerve: Anatomy and Pathology.
Lucio LL, Freddi TAL, Ottaiano AC
Semin Ultrasound CT MR 2022 Oct;43(5):414-419. Epub 2022 Apr 18 doi: 10.1053/j.sult.2022.04.008. PMID: 36116854
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
The Medial Pontine Mid-Tegmentum Syndrome.
Wadi LC, Kim MJ, Fisher MJ
J Stroke Cerebrovasc Dis 2020 Jun;29(6):104750. Epub 2020 Mar 24 doi: 10.1016/j.jstrokecerebrovasdis.2020.104750. PMID: 32220556
Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum.
Manara R, Brotto D, Ghiselli S, Mardari R, Toldo I, Schifano G, Cantone E, Bovo R, Martini A
AJNR Am J Neuroradiol 2015 Jul;36(7):1375-80. Epub 2015 Mar 26 doi: 10.3174/ajnr.A4273. PMID: 25814660Free PMC Article
Cranial nerve defects in congenital facial palsy.
Carr MM, Ross DA, Zuker RM
J Otolaryngol 1997 Apr;26(2):80-7. PMID: 9106081

Clinical prediction guides

Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Clinical correlation of imaging findings in congenital cranial dysinnervation disorders involving abducens nerve.
Gupta C, Sharma P, Saxena R, Garg A, Sharma S
Indian J Ophthalmol 2017 Feb;65(2):155-159. doi: 10.4103/ijo.IJO_1013_15. PMID: 28345573Free PMC Article
Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum.
Manara R, Brotto D, Ghiselli S, Mardari R, Toldo I, Schifano G, Cantone E, Bovo R, Martini A
AJNR Am J Neuroradiol 2015 Jul;36(7):1375-80. Epub 2015 Mar 26 doi: 10.3174/ajnr.A4273. PMID: 25814660Free PMC Article
Nuclear and infranuclear disorders.
Meienberg O, Müri R
Baillieres Clin Neurol 1992 Aug;1(2):417-34. PMID: 1344077
Möbius and Möbius-like syndromes (TTV-OFM, OMLH).
Miller MT, Ray V, Owens P, Chen F
J Pediatr Ophthalmol Strabismus 1989 Jul-Aug;26(4):176-88. doi: 10.3928/0191-3913-19890701-07. PMID: 2668494

Recent systematic reviews

Cranial nerve injuries in Le Fort I osteotomy: a systematic review.
Dos Santos Alves JM, de Freitas Alves BW, de Figueiredo Costa AC, Carneiro BGDS, de Sousa LM, Gondim DV
Int J Oral Maxillofac Surg 2019 May;48(5):601-611. Epub 2018 Dec 28 doi: 10.1016/j.ijom.2018.11.012. PMID: 30598335

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