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Symptomatic seizures

MedGen UID:: 869098
•Concept ID:: C4023516
•: Sign or Symptom

HPO:	HP:0011145

Definition

A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSymptomatic seizures

Abnormality of prenatal development or birth
- Fetal anomaly
  - Congenital Systemic Disorder
    - Abnormality of the nervous system
      - Abnormal nervous system physiology
        Seizure
        Symptomatic seizures
        Hypocalcemic seizures
        Hypoglycemic seizures

Professional guidelines

PubMed

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.

Galovic M, Ferreira-Atuesta C, Abraira L, Döhler N, Sinka L, Brigo F, Bentes C, Zelano J, Koepp MJ
Drugs Aging 2021 Apr;38(4):285-299. Epub 2021 Feb 23 doi: 10.1007/s40266-021-00837-7. PMID: 33619704 Free PMC Article

Neonatal Seizures: Diagnosis, Etiologies, and Management.

Ziobro J, Shellhaas RA
Semin Neurol 2020 Apr;40(2):246-256. Epub 2020 Mar 6 doi: 10.1055/s-0040-1702943. PMID: 32143234

Emergency Management of Epilepsy and Seizures.

Bank AM, Bazil CW
Semin Neurol 2019 Feb;39(1):73-81. Epub 2019 Feb 11 doi: 10.1055/s-0038-1677008. PMID: 30743294

See all (34)

Recent clinical studies

Etiology

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.

How to diagnose and treat post-stroke seizures and epilepsy.

Zelano J, Holtkamp M, Agarwal N, Lattanzi S, Trinka E, Brigo F
Epileptic Disord 2020 Jun 1;22(3):252-263. doi: 10.1684/epd.2020.1159. PMID: 32597766

Neonatal Seizures: Diagnosis, Etiologies, and Management.

Ziobro J, Shellhaas RA
Semin Neurol 2020 Apr;40(2):246-256. Epub 2020 Mar 6 doi: 10.1055/s-0040-1702943. PMID: 32143234

The Epidemiology of Epilepsy.

Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003

Management of a First Seizure.

Bergey GK
Continuum (Minneap Minn) 2016 Feb;22(1 Epilepsy):38-50. doi: 10.1212/CON.0000000000000271. PMID: 26844729

See all (290)

Diagnosis

Acute symptomatic seizures: an educational, evidence-based review.

Mauritz M, Hirsch LJ, Camfield P, Chin R, Nardone R, Lattanzi S, Trinka E
Epileptic Disord 2022 Feb 1;24(1):26-49. doi: 10.1684/epd.2021.1376. PMID: 34789447

Novel Therapeutics for Neonatal Seizures.

Ziobro JM, Eschbach K, Shellhaas RA
Neurotherapeutics 2021 Jul;18(3):1564-1581. Epub 2021 Aug 12 doi: 10.1007/s13311-021-01085-8. PMID: 34386906 Free PMC Article

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.

Neonatal Seizures: Diagnosis, Etiologies, and Management.

Ziobro J, Shellhaas RA
Semin Neurol 2020 Apr;40(2):246-256. Epub 2020 Mar 6 doi: 10.1055/s-0040-1702943. PMID: 32143234

The Epidemiology of Epilepsy.

Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003

See all (228)

Therapy

Novel Therapeutics for Neonatal Seizures.

Ziobro JM, Eschbach K, Shellhaas RA
Neurotherapeutics 2021 Jul;18(3):1564-1581. Epub 2021 Aug 12 doi: 10.1007/s13311-021-01085-8. PMID: 34386906 Free PMC Article

Antiepileptic Drugs and Liver Disease.

Vidaurre J, Gedela S, Yarosz S
Pediatr Neurol 2017 Dec;77:23-36. Epub 2017 Sep 22 doi: 10.1016/j.pediatrneurol.2017.09.013. PMID: 29097018

New-Onset Seizure in Adults and Adolescents: A Review.

Gavvala JR, Schuele SU
JAMA 2016 Dec 27;316(24):2657-2668. doi: 10.1001/jama.2016.18625. PMID: 28027373

Management of a First Seizure.

Bergey GK
Continuum (Minneap Minn) 2016 Feb;22(1 Epilepsy):38-50. doi: 10.1212/CON.0000000000000271. PMID: 26844729

Seizures as adverse events of antibiotic drugs: A systematic review.

Sutter R, Rüegg S, Tschudin-Sutter S
Neurology 2015 Oct 13;85(15):1332-41. Epub 2015 Sep 23 doi: 10.1212/WNL.0000000000002023. PMID: 26400582

See all (134)

Prognosis

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.

Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune-associated epilepsy: Conceptual definitions.

Steriade C, Britton J, Dale RC, Gadoth A, Irani SR, Linnoila J, McKeon A, Shao XQ, Venegas V, Bien CG
Epilepsia 2020 Jul;61(7):1341-1351. Epub 2020 Jun 16 doi: 10.1111/epi.16571. PMID: 32544279

Neonatal Seizures: Diagnosis, Etiologies, and Management.

Ziobro J, Shellhaas RA
Semin Neurol 2020 Apr;40(2):246-256. Epub 2020 Mar 6 doi: 10.1055/s-0040-1702943. PMID: 32143234

The Epidemiology of Epilepsy.

Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003

Antiepileptic Drugs and Liver Disease.

Vidaurre J, Gedela S, Yarosz S
Pediatr Neurol 2017 Dec;77:23-36. Epub 2017 Sep 22 doi: 10.1016/j.pediatrneurol.2017.09.013. PMID: 29097018

See all (205)

Clinical prediction guides

Autoimmune-Associated Seizures.

Gillinder L, Britton J
Continuum (Minneap Minn) 2022 Apr 1;28(2):363-398. doi: 10.1212/CON.0000000000001079. PMID: 35393963

Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures.

Glass HC, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Lemmon M, Thomas C, Numis AL, Guillet R, Sturza J, McNamara NA, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA
JAMA Neurol 2021 Jul 1;78(7):817-825. doi: 10.1001/jamaneurol.2021.1437. PMID: 34028496 Free PMC Article

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.

Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.

Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337

New-Onset Seizure in Adults and Adolescents: A Review.

Gavvala JR, Schuele SU
JAMA 2016 Dec 27;316(24):2657-2668. doi: 10.1001/jama.2016.18625. PMID: 28027373

See all (157)

Recent systematic reviews

Statins in primary prevention of poststroke seizures and epilepsy: A systematic review.

Nucera B, Rinaldi F, Nardone R, Lattanzi S, Brigo F
Epilepsy Behav 2020 Nov;112:107400. Epub 2020 Sep 8 doi: 10.1016/j.yebeh.2020.107400. PMID: 32916580

Hypertension, seizures, and epilepsy: a review on pathophysiology and management.

Gasparini S, Ferlazzo E, Sueri C, Cianci V, Ascoli M, Cavalli SM, Beghi E, Belcastro V, Bianchi A, Benna P, Cantello R, Consoli D, De Falco FA, Di Gennaro G, Gambardella A, Gigli GL, Iudice A, Labate A, Michelucci R, Paciaroni M, Palumbo P, Primavera A, Sartucci F, Striano P, Villani F, Russo E, De Sarro G, Aguglia U; Epilepsy Study Group of the Italian Neurological Society
Neurol Sci 2019 Sep;40(9):1775-1783. Epub 2019 May 4 doi: 10.1007/s10072-019-03913-4. PMID: 31055731

Seizures as adverse events of antibiotic drugs: A systematic review.

Sutter R, Rüegg S, Tschudin-Sutter S
Neurology 2015 Oct 13;85(15):1332-41. Epub 2015 Sep 23 doi: 10.1212/WNL.0000000000002023. PMID: 26400582

Recommendation for a definition of acute symptomatic seizure.

Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser WA
Epilepsia 2010 Apr;51(4):671-5. Epub 2009 Sep 3 doi: 10.1111/j.1528-1167.2009.02285.x. PMID: 19732133

See all (12)

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Symptomatic seizures

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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