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Onycholysis of distal fingernails

MedGen UID:
870242
Concept ID:
C4024680
Finding
Synonym: Detachment of outermost fingernails
 
HPO: HP:0008400

Definition

Detachment of the distal fingernails from the nail bed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOnycholysis of distal fingernails

Conditions with this feature

Nonsyndromic congenital nail disorder 5
MedGen UID:
318994
Concept ID:
C1833909
Disease or Syndrome
Hereditary distal onycholysis is an autosomal dominant nail disorder characterized by a decreased rate of growth of the nail, scleronychia, and a straight or concave proximal edge of detachment. Clinical features may include palmoplantar hyperhydrosis and marked sensitivity of the fingers to cold (summary by Bazex et al., 1990). Hereditary distal onycholysis is referred to here as nonsyndromic congenital nail disorder-5 (NDNC5). For a list of other nonsyndromic congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (161050).
Nonsyndromic congenital nail disorder 9
MedGen UID:
481577
Concept ID:
C3279947
Disease or Syndrome
Although nails appear normal at birth, dystrophic changes develop within the first decade of life, resulting in onycholysis of fingernails and anonychia of toenails (summary by Rafiq et al., 2004). This disorder is referred to here as nonsyndromic congenital nail disorder-9 (NDNC9). For a list of other nonsyndromic congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (161050).
Epidermolysis bullosa, junctional 5A, intermediate
MedGen UID:
1811851
Concept ID:
C5676956
Disease or Syndrome
Intermediate junctional epidermolysis bullosa 5A (JEB5A) is an autosomal recessive blistering disease of skin and mucous membranes. Blistering is less severe than in severe JEB (see 226700). The plane of skin cleavage is through the lamina lucida of the cutaneous basement membrane zone. Nails may be dystrophic and dental enamel defects are present. Blistering does not affect the life span of affected individuals (summary by Has et al., 2020). For a discussion of genetic heterogeneity of the subtypes of JEB, see JEB1A (226650). Reviews Has et al. (2020) reviewed the clinical and genetic aspects, genotype-phenotype correlations, disease-modifying factors, and natural history of epidermolysis bullosa.

Professional guidelines

PubMed

Baran R, Hay RJ, Garduno JI
J Dermatolog Treat 2008;19(3):168-75. doi: 10.1080/09546630701657187. PMID: 18569273

Recent clinical studies

Etiology

Shemer A, Daniel R, Lyakhovitsky A, Aghion-Svirsky V, Kassem R, Rigopoulos D, Farhi R, Galili E
Mycoses 2020 Sep;63(9):964-969. Epub 2020 Jul 4 doi: 10.1111/myc.13133. PMID: 32563206
Damasco FM, Geskin LJ, Akilov OE
J Cutan Med Surg 2019 Jul/Aug;23(4):380-387. Epub 2019 Mar 27 doi: 10.1177/1203475419839937. PMID: 30917680
Rouzaud M, Sevrain M, Villani AP, Barnetche T, Paul C, Richard MA, Jullien D, Misery L, Le Maître M, Aractingi S, Aubin F, Joly P, Cantagrel A, Ortonne JP, Beylot-Barry M
J Eur Acad Dermatol Venereol 2014 Aug;28 Suppl 5:17-26. doi: 10.1111/jdv.12562. PMID: 24985559
Baran R, Hay RJ, Garduno JI
J Dermatolog Treat 2008;19(3):168-75. doi: 10.1080/09546630701657187. PMID: 18569273
Sharquie IK, Al-Faham M, Karhoot JM, Sharquie KE, Al-Waiz MM, Al-Douri WS
Saudi Med J 2005 Sep;26(9):1439-41. PMID: 16155665

Diagnosis

Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Shemer A, Daniel R, Lyakhovitsky A, Aghion-Svirsky V, Kassem R, Rigopoulos D, Farhi R, Galili E
Mycoses 2020 Sep;63(9):964-969. Epub 2020 Jul 4 doi: 10.1111/myc.13133. PMID: 32563206
Hibler BP, Rossi AM, DeLeo VA
Cutis 2017 Jan;99(1):E8-E11. PMID: 28207012
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276
Grover C, Reddy BS, Uma Chaturvedi K
Br J Dermatol 2005 Dec;153(6):1153-8. doi: 10.1111/j.1365-2133.2005.06862.x. PMID: 16307651

Therapy

Shemer A, Daniel R, Lyakhovitsky A, Aghion-Svirsky V, Kassem R, Rigopoulos D, Farhi R, Galili E
Mycoses 2020 Sep;63(9):964-969. Epub 2020 Jul 4 doi: 10.1111/myc.13133. PMID: 32563206
Hibler BP, Rossi AM, DeLeo VA
Cutis 2017 Jan;99(1):E8-E11. PMID: 28207012
Chiriac A, Stanciu R, Brzezinski P, Feldman SR
Dermatol Online J 2014 Sep 16;20(9) PMID: 25244179
Elewski BE, Rich P, Tosti A, Pariser DM, Scher R, Daniel RC, Gupta AK
J Drugs Dermatol 2013 Jul 1;12(7):s96-103. PMID: 23884508
Baran R, Hay RJ, Garduno JI
J Dermatolog Treat 2008;19(3):168-75. doi: 10.1080/09546630701657187. PMID: 18569273

Prognosis

Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Shemer A, Daniel R, Lyakhovitsky A, Aghion-Svirsky V, Kassem R, Rigopoulos D, Farhi R, Galili E
Mycoses 2020 Sep;63(9):964-969. Epub 2020 Jul 4 doi: 10.1111/myc.13133. PMID: 32563206
Rouzaud M, Sevrain M, Villani AP, Barnetche T, Paul C, Richard MA, Jullien D, Misery L, Le Maître M, Aractingi S, Aubin F, Joly P, Cantagrel A, Ortonne JP, Beylot-Barry M
J Eur Acad Dermatol Venereol 2014 Aug;28 Suppl 5:17-26. doi: 10.1111/jdv.12562. PMID: 24985559
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276
Sharquie IK, Al-Faham M, Karhoot JM, Sharquie KE, Al-Waiz MM, Al-Douri WS
Saudi Med J 2005 Sep;26(9):1439-41. PMID: 16155665

Clinical prediction guides

Bhoi AK, Grover C, Singal A, Tandon A
Indian J Dermatol Venereol Leprol 2023 Nov-Dec;89(6):854-861. doi: 10.25259/IJDVL_894_2022. PMID: 37317728
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Damasco FM, Geskin LJ, Akilov OE
J Cutan Med Surg 2019 Jul/Aug;23(4):380-387. Epub 2019 Mar 27 doi: 10.1177/1203475419839937. PMID: 30917680
Cohen PR
Am J Clin Dermatol 2011 Aug 1;12(4):217-31. doi: 10.2165/11586910-000000000-00000. PMID: 21668031
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276

Recent systematic reviews

Rouzaud M, Sevrain M, Villani AP, Barnetche T, Paul C, Richard MA, Jullien D, Misery L, Le Maître M, Aractingi S, Aubin F, Joly P, Cantagrel A, Ortonne JP, Beylot-Barry M
J Eur Acad Dermatol Venereol 2014 Aug;28 Suppl 5:17-26. doi: 10.1111/jdv.12562. PMID: 24985559

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