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Maternal virilization in pregnancy

MedGen UID:
870293
•Concept ID:
C4024735
•
Finding
HPO: HP:0008072

Definition

Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaternal virilization in pregnancy

Professional guidelines

PubMed

P450 Oxidoreductase Deficiency: A Systematic Review and Meta-analysis of Genotypes, Phenotypes, and Their Relationships.
Dean B, Chrisp GL, Quartararo M, Maguire AM, Hameed S, King BR, Munns CF, Torpy DJ, Falhammar H, Rushworth RL
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgz255. PMID: 31825489

Recent clinical studies

Etiology

MATERNAL ACTIVITY DURING PREGNANCY AND SEXUALLY DIMORPHIC TRAITS IN OFFSPRING.
Ellis L, Eisenman R, Hoskin A
J Biosoc Sci 2018 Jan;50(1):114-123. Epub 2017 Apr 3 doi: 10.1017/S0021932017000074. PMID: 28366175
Adrenal disease in pregnancy.
Lekarev O, New MI
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):959-73. doi: 10.1016/j.beem.2011.08.004. PMID: 22115169
Hyperandrogenic states in pregnancy.
Kaňová N, Bičíková M
Physiol Res 2011;60(2):243-52. Epub 2010 Nov 29 doi: 10.33549/physiolres.932078. PMID: 21114372
Congenital adrenal hyperplasia.
Pang S
Endocrinol Metab Clin North Am 1997 Dec;26(4):853-91. doi: 10.1016/s0889-8529(05)70285-1. PMID: 9429863
Adolescent menstrual irregularity.
Mansfield MJ, Emans SJ
J Reprod Med 1984 Jun;29(6):399-410. PMID: 6379175

Diagnosis

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis.
Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R
Arch Gynecol Obstet 2021 Jan;303(1):129-134. Epub 2020 Aug 19 doi: 10.1007/s00404-020-05745-6. PMID: 32815025Free PMC Article
New developments in prenatal diagnosis of congenital adrenal hyperplasia.
Kazmi D, Bailey J, Yau M, Abu-Amer W, Kumar A, Low M, Yuen T
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):121-123. Epub 2016 Jul 1 doi: 10.1016/j.jsbmb.2016.06.016. PMID: 27378492
Adrenal disease in pregnancy.
Lekarev O, New MI
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):959-73. doi: 10.1016/j.beem.2011.08.004. PMID: 22115169
Congenital adrenal hyperplasia.
Pang S
Endocrinol Metab Clin North Am 1997 Dec;26(4):853-91. doi: 10.1016/s0889-8529(05)70285-1. PMID: 9429863
Adolescent menstrual irregularity.
Mansfield MJ, Emans SJ
J Reprod Med 1984 Jun;29(6):399-410. PMID: 6379175

Therapy

New developments in prenatal diagnosis of congenital adrenal hyperplasia.
Kazmi D, Bailey J, Yau M, Abu-Amer W, Kumar A, Low M, Yuen T
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):121-123. Epub 2016 Jul 1 doi: 10.1016/j.jsbmb.2016.06.016. PMID: 27378492
Management of congenital adrenal hyperplasia in childhood.
Kim MS, Ryabets-Lienhard A, Geffner ME
Curr Opin Endocrinol Diabetes Obes 2012 Dec;19(6):483-8. doi: 10.1097/MED.0b013e32835a1a1b. PMID: 23037928Free PMC Article
Adrenal disease in pregnancy.
Lekarev O, New MI
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):959-73. doi: 10.1016/j.beem.2011.08.004. PMID: 22115169
Congenital adrenal hyperplasia.
Pang S
Endocrinol Metab Clin North Am 1997 Dec;26(4):853-91. doi: 10.1016/s0889-8529(05)70285-1. PMID: 9429863
Adolescent menstrual irregularity.
Mansfield MJ, Emans SJ
J Reprod Med 1984 Jun;29(6):399-410. PMID: 6379175

Prognosis

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis.
Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R
Arch Gynecol Obstet 2021 Jan;303(1):129-134. Epub 2020 Aug 19 doi: 10.1007/s00404-020-05745-6. PMID: 32815025Free PMC Article
Men's experiences of pregnancy and childbirth in Sierra Leone: Reexamining definitions of "male partner involvement".
McLean KE
Soc Sci Med 2020 Nov;265:113479. Epub 2020 Oct 29 doi: 10.1016/j.socscimed.2020.113479. PMID: 33218892
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature.
Bustamante C, Hoyos-Martínez A, Pirela D, Díaz A
J Pediatr Endocrinol Metab 2017 Jul 26;30(7):785-790. doi: 10.1515/jpem-2016-0433. PMID: 28682787
Congenital adrenal hyperplasia: 21-hydroxylase deficiency in the newborn and during infancy.
Hughes IA
Semin Reprod Med 2002 Aug;20(3):229-42. doi: 10.1055/s-2002-35387. PMID: 12428203
Congenital adrenal hyperplasia.
Pang S
Endocrinol Metab Clin North Am 1997 Dec;26(4):853-91. doi: 10.1016/s0889-8529(05)70285-1. PMID: 9429863

Clinical prediction guides

Imaging features, clinical characteristics and neonatal outcomes of pregnancy luteoma: A case series and literature review.
Shang JH, Huang CX, Zheng Q, Feng JL, He K, Xie HN
Acta Obstet Gynecol Scand 2024 Apr;103(4):740-750. Epub 2023 Sep 14 doi: 10.1111/aogs.14672. PMID: 37710408Free PMC Article
Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis.
Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R
Arch Gynecol Obstet 2021 Jan;303(1):129-134. Epub 2020 Aug 19 doi: 10.1007/s00404-020-05745-6. PMID: 32815025Free PMC Article
Hyperreactio Luteinalis: Maternal and Fetal Effects.
Malinowski AK, Sen J, Sermer M
J Obstet Gynaecol Can 2015 Aug;37(8):715-723. doi: 10.1016/S1701-2163(15)30176-6. PMID: 26474228
Mosaics and moles.
Sunde L, Niemann I, Hansen ES, Hindkjaer J, Degn B, Jensen UB, Bolund L
Eur J Hum Genet 2011 Oct;19(10):1026-31. Epub 2011 Jun 8 doi: 10.1038/ejhg.2011.93. PMID: 21654731Free PMC Article
Congenital adrenal hyperplasia.
Pang S
Endocrinol Metab Clin North Am 1997 Dec;26(4):853-91. doi: 10.1016/s0889-8529(05)70285-1. PMID: 9429863

Recent systematic reviews

Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.
Fan L, Zhang B, Li L, Gong C
Clin Endocrinol (Oxf) 2020 Dec;93(6):687-695. Epub 2020 Jul 27 doi: 10.1111/cen.14277. PMID: 32623730
P450 Oxidoreductase Deficiency: A Systematic Review and Meta-analysis of Genotypes, Phenotypes, and Their Relationships.
Dean B, Chrisp GL, Quartararo M, Maguire AM, Hameed S, King BR, Munns CF, Torpy DJ, Falhammar H, Rushworth RL
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgz255. PMID: 31825489
Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718
Prenatal dexamethasone use for the prevention of virilization in pregnancies at risk for classical congenital adrenal hyperplasia because of 21-hydroxylase (CYP21A2) deficiency: a systematic review and meta-analyses.
Mercè Fernández-Balsells M, Muthusamy K, Smushkin G, Lampropulos JF, Elamin MB, Abu Elnour NO, Elamin KB, Agrwal N, Gallegos-Orozco JF, Lane MA, Erwin PJ, Montori VM, Murad MH
Clin Endocrinol (Oxf) 2010 Oct;73(4):436-44. doi: 10.1111/j.1365-2265.2010.03826.x. PMID: 20550539

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