Atrophy/Degeneration affecting the central nervous system

MedGen UID:: 870453
•Concept ID:: C4024899
•: Pathologic Function

Synonym:	Atrophy/Degeneration affecting the CNS

HPO:	HP:0007367

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Atrophy/Degeneration affecting the central nervous system

Abnormality of prenatal development or birth
- Fetal anomaly
  - Congenital Systemic Disorder
    - Abnormality of the nervous system
      - Abnormal nervous system morphology
        Morphological central nervous system abnormality
        Atrophy/Degeneration affecting the central nervous system
        Atrophy/Degeneration affecting the brainstem
        Atrophy/Degeneration involving the corticospinal tracts
        Corticospinal tract atrophy
        Degeneration of the lateral corticospinal tracts
        Atrophy/Degeneration involving the spinal cord
        Atrophy of the spinal cord
        Cervical spinal cord atrophy
        Central nervous system degeneration
        Increased cerebral lipofuscin
        Increased extraneuronal autofluorescent lipopigment
        Increased neuronal autofluorescent lipopigment
        Motor neuron atrophy
        Amyotrophic lateral sclerosis
        Amyotrophic Lateral Sclerosis 14, With or Without Frontotemporal Dementia
        Amyotrophic lateral sclerosis type 1
        Amyotrophic lateral sclerosis type 3
        Amyotrophic lateral sclerosis type 4
        Amyotrophic lateral sclerosis type 6
        Amyotrophic lateral sclerosis type 7
        Amyotrophic lateral sclerosis type 8
        Amyotrophic lateral sclerosis type 9
        Amyotrophic lateral sclerosis type 10
        Amyotrophic lateral sclerosis type 11
        Amyotrophic lateral sclerosis type 21
        Amyotrophic lateral sclerosis type 23
        Juvenile amyotrophic lateral sclerosis
        Progressive muscular atrophy
        Degeneration of anterior horn cells
        Neurodegeneration
        Granulovacuolar degeneration
        Nissl degeneration
        Subacute combined degeneration of spinal cord
        Wallerian degeneration
        Neuronal loss in central nervous system
        Senile plaques
        Cotton wool plaques

Recent clinical studies

Diagnosis

Genome sequencing in a case of Niemann-Pick type C.

Dougherty M, Lazar J, Klein JC, Diaz K, Gobillot T, Grunblatt E, Hasle N, Lawrence D, Maurano M, Nelson M, Olson G, Srivatsan S, Shendure J, Keene CD, Bird T, Horwitz MS, Marshall DA
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001222. doi: 10.1101/mcs.a001222. PMID: 27900365 Free PMC Article

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Atrophy/Degeneration affecting the central nervous system

Term Hierarchy

Recent clinical studies

Diagnosis

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