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Bilateral intracerebral calcifications

MedGen UID:
Concept ID:
Synonym: Bilateral intracranial calcifications
HPO: HP:0005671


Deposition of calcium salts on both sides of the cerebrum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBilateral intracerebral calcifications

Conditions with this feature

Lipid proteinosis
MedGen UID:
Concept ID:
Disease or Syndrome
Lipoid proteinosis (LP) is characterized by deposition of hyaline-like material in various tissues resulting in a hoarse voice from early infancy, vesicles and hemorrhagic crusts in the mouth and on the face and extremities, verrucous and keratotic cutaneous lesions on extensor surfaces (especially the elbows), and moniliform blepharosis (multiple beaded papules along the eyelid margins and inner canthus). Extracutaneous manifestations may include epilepsy, neuropsychiatric disorders, spontaneous CNS hemorrhage, and asymptomatic multiple yellowish nodules throughout the gastrointestinal tract. Generally, the disease course is chronic and fluctuating. Males and females are affected equally. Affected individuals have a normal life span unless they experience laryngeal obstruction.

Recent clinical studies


Sachs C, Sjöberg HE, Ericson K
Neurology 1982 Jul;32(7):779-82. doi: 10.1212/wnl.32.7.779. PMID: 7201117


Pacheco D, Travassos AR, Antunes J, Marques MS, Filipe P, Silva R
Dermatol Online J 2013 Jun 15;19(6):18569. PMID: 24011318

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