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Multiple digital exostoses

MedGen UID:
870708
•Concept ID:
C4025162
•
Neoplastic Process
HPO: HP:0005655

Definition

Multiple exostoses originating in the fingers and toes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple digital exostoses

Conditions with this feature

Metachondromatosis
MedGen UID:
98377
•Concept ID:
C0410530
•
Disease or Syndrome
Metachondromatosis is characterized by exostoses (osteochondromas), commonly of the hands and feet, and enchondromas of long bone metaphyses and iliac crests (summary by Sobreira et al., 2010).
See: Condition Record
Metachondromatosis

Recent clinical studies

Etiology

Determining the factors influencing the symptoms related to naviculo-medial cuneiform coalition.
Choi JY, Chun KA, Lee DJ, Cho ST, Suh JS
J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019832719. doi: 10.1177/2309499019832719. PMID: 30827191
Is hip dysplasia a common deformity in skeletally mature patients with hereditary multiple exostoses?
Higuchi C, Sugano N, Yoshida K, Yoshikawa H
J Orthop Sci 2016 May;21(3):323-6. Epub 2016 Mar 4 doi: 10.1016/j.jos.2016.02.005. PMID: 26951643
Involvement of the spine in patients with multiple hereditary exostoses.
Roach JW, Klatt JW, Faulkner ND
J Bone Joint Surg Am 2009 Aug;91(8):1942-8. doi: 10.2106/JBJS.H.00762. PMID: 19651953
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Chondrosarcoma arising in osteochondroma.
Garrison RC, Unni KK, McLeod RA, Pritchard DJ, Dahlin DC
Cancer 1982 May 1;49(9):1890-7. doi: 10.1002/1097-0142(19820501)49:9<1890::aid-cncr2820490923>3.0.co;2-u. PMID: 7074587

Diagnosis

Osteochondroma of acromioclavicular joint.
Baig MN, O'Malley S, Fenelon C, Kaar K
BMJ Case Rep 2019 Aug 22;12(8) doi: 10.1136/bcr-2019-230246. PMID: 31444263Free PMC Article
Multidetector computed tomography in the evaluation of hereditary multiple exostoses.
Kwee RM, Fayad LM, Fishman EK, Fritz J
Eur J Radiol 2016 Feb;85(2):383-91. Epub 2015 Nov 28 doi: 10.1016/j.ejrad.2015.11.034. PMID: 26781144
Multiple Hereditary Exostoses.
DuBose CO
Radiol Technol 2016 Jan-Feb;87(3):305-21. quiz 322-5. PMID: 26721841
Five polyostotic conditions that general orthopedic surgeons should recognize (or should not miss).
Muthusamy S, Conway SA, Temple HT
Orthop Clin North Am 2014 Jul;45(3):417-29. doi: 10.1016/j.ocl.2014.04.004. PMID: 24975767
Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation.
Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH
Radiographics 2000 Sep-Oct;20(5):1407-34. doi: 10.1148/radiographics.20.5.g00se171407. PMID: 10992031

Therapy

Spontaneous absorption of osteophytic calcification associated with chronic dural tear and ventral spinal CSF leak.
Rohatgi VK, Robbins MS, Schievink WI, Chazen JL
Neuroradiol J 2024 Apr;37(2):257-260. Epub 2023 Jun 30 doi: 10.1177/19714009231187360. PMID: 37387398Free PMC Article
A Novel Cause of Acute Coronary Syndrome Due to Dynamic Extrinsic Coronary Artery Compression by a Rib Exostosis: Multimodality Imaging Diagnosis.
Rodrigues JC, Mathias HC, Lyen SM, Mcalindon E, Bucciarelli-Ducci C, Batchelor TJ, Hamilton MC, Manghat NE
Can J Cardiol 2015 Oct;31(10):1303.e9-1303.e11. Epub 2015 May 16 doi: 10.1016/j.cjca.2015.05.008. PMID: 26255213
Selective computed tomography-guided perisciatic injection as a diagnostic tool in multiple hereditary exostoses.
Tenenbaum S, Arzi H, Shabshin N, Liberman B, Caspi I
Orthopedics 2012 Sep;35(9):e1446-8. doi: 10.3928/01477447-20120822-38. PMID: 22955418
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report.
Pandya NK, Auerbach JD, Baldwin K, Lackman RD, Chin KR
Spine (Phila Pa 1976) 2006 Nov 15;31(24):E920-4. doi: 10.1097/01.brs.0000245926.30594.bf. PMID: 17108823

Prognosis

Chest wall osteochondroma in children: a case series of surgical management.
Bakhshi H, Kushare I, Murphy MO, Gaynor JW, Dormans JP
J Pediatr Orthop 2014 Oct-Nov;34(7):733-7. doi: 10.1097/BPO.0000000000000153. PMID: 25210940
Five polyostotic conditions that general orthopedic surgeons should recognize (or should not miss).
Muthusamy S, Conway SA, Temple HT
Orthop Clin North Am 2014 Jul;45(3):417-29. doi: 10.1016/j.ocl.2014.04.004. PMID: 24975767
An unusual complication of pubic exostosis.
Mnif H, Zrig M, Koubaa M, Zammel N, Abid A
Orthop Traumatol Surg Res 2009 Apr;95(2):151-3. Epub 2009 Mar 24 doi: 10.1016/j.otsr.2009.02.003. PMID: 19321394
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Kissing osteochondromata leading to synostoses.
Bessler W, Eich G, Stuckmann G, Zollikofer C
Eur Radiol 1997;7(4):480-5. doi: 10.1007/s003300050188. PMID: 9204324

Clinical prediction guides

Multiple unexpected lesions of metachondromatosis detected by technetium-99m methylene diphosphonate SPECT/CT: A case report.
Wang Z, Zou Y, Chen Y, Chen Y
Medicine (Baltimore) 2018 Apr;97(17):e0512. doi: 10.1097/MD.0000000000010512. PMID: 29703018Free PMC Article
Hip-Spine Syndrome: Is There an Association Between Markers for Cam Deformity and Osteoarthritis of the Lumbar Spine?
Gebhart JJ, Weinberg DS, Conry KT, Morris WZ, Sasala LM, Liu RW
Arthroscopy 2016 Nov;32(11):2243-2248. Epub 2016 Jun 11 doi: 10.1016/j.arthro.2016.04.025. PMID: 27296870
Otofaciocervical syndrome and metachondromatosis in a girl: Presentation of a novel association and remarks on clinical variability of branchial-arch disorders.
Salinas-Torres VM, Salinas-Torres RA
Int J Pediatr Otorhinolaryngol 2016 Jun;85:19-21. Epub 2016 Mar 22 doi: 10.1016/j.ijporl.2016.03.021. PMID: 27240490
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Secondary chondrosarcoma in osteochondroma: report of 107 patients.
Ahmed AR, Tan TS, Unni KK, Collins MS, Wenger DE, Sim FH
Clin Orthop Relat Res 2003 Jun;(411):193-206. doi: 10.1097/01.blo.0000069888.31220.2b. PMID: 12782876

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