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Abnormality of the urethra

MedGen UID:
871336
•Concept ID:
C4025826
•
Anatomical Abnormality
Synonym: Urethra issue
 
HPO: HP:0000795

Definition

An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. [from HPO]

Professional guidelines

PubMed

Role of Genetic Counseling for Patients with Hypospadias and Their Families.
Nordenskjöld A, Holmdahl G
Eur J Pediatr Surg 2021 Dec;31(6):492-496. Epub 2021 Dec 15 doi: 10.1055/s-0041-1740339. PMID: 34911131
The current state of tissue engineering in the management of hypospadias.
Chan YY, Bury MI, Yura EM, Hofer MD, Cheng EY, Sharma AK
Nat Rev Urol 2020 Mar;17(3):162-175. Epub 2020 Feb 5 doi: 10.1038/s41585-020-0281-4. PMID: 32024995
Evaluation and Management of Neurogenic Bladder: What Is New in China?
Liao L
Int J Mol Sci 2015 Aug 10;16(8):18580-600. doi: 10.3390/ijms160818580. PMID: 26266405Free PMC Article

Recent clinical studies

Etiology

Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Zhang Q, Zhang Z, He X, Liu Z, Shen L, Long C, Wei G, Liu X
J Pediatr Urol 2023 Oct;19(5):581.e1-581.e6. Epub 2023 May 13 doi: 10.1016/j.jpurol.2023.05.006. PMID: 37246119
Long-term outcome of urethral and genital reconstruction in hypospadias and exstrophy-epispadias complex.
Sinatti C, Schechter MY, Spinoit AF, Hoebeke P
Curr Opin Urol 2021 Sep 1;31(5):480-485. doi: 10.1097/MOU.0000000000000920. PMID: 34231544
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Midshaft hypospadias.
Upadhyay J, Shekarriz B, Khoury AE
Urol Clin North Am 2002 May;29(2):299-310. doi: 10.1016/s0094-0143(02)00049-6. PMID: 12371222

Diagnosis

Congenital Urethrocutaneous Fistula.
Suman BK, Singh RJ, Sinha AK, Kumar B
Afr J Paediatr Surg 2024 Jan 1;21(1):73-74. Epub 2023 Jul 20 doi: 10.4103/ajps.ajps_97_22. PMID: 38259026Free PMC Article
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988
Posterior urethral valves.
Hodges SJ, Patel B, McLorie G, Atala A
ScientificWorldJournal 2009 Oct 14;9:1119-26. doi: 10.1100/tsw.2009.127. PMID: 19838598Free PMC Article
Antenatally detected hydronephrosis.
Piepsz A
Semin Nucl Med 2007 Jul;37(4):249-60. doi: 10.1053/j.semnuclmed.2007.02.008. PMID: 17544625

Therapy

Analysis in the influence factors of urethroplasty in DSD.
Yu J, Sun N, Song H, Li M, Li L, Gong C, Zhang W
BMC Urol 2022 Aug 10;22(1):124. doi: 10.1186/s12894-022-01080-x. PMID: 35948888Free PMC Article
The current state of tissue engineering in the management of hypospadias.
Chan YY, Bury MI, Yura EM, Hofer MD, Cheng EY, Sharma AK
Nat Rev Urol 2020 Mar;17(3):162-175. Epub 2020 Feb 5 doi: 10.1038/s41585-020-0281-4. PMID: 32024995
Genitourinary Complications of Gender-Affirming Surgery.
Bryson C, Honig SC
Curr Urol Rep 2019 Apr 30;20(6):31. doi: 10.1007/s11934-019-0894-4. PMID: 31041616
Hypospadias.
Macedo A Jr, Rondon A, Ortiz V
Curr Opin Urol 2012 Nov;22(6):447-52. doi: 10.1097/MOU.0b013e328357bc62. PMID: 23026892
Hypospadias.
Shukla AR, Patel RP, Canning DA
Urol Clin North Am 2004 Aug;31(3):445-60, viii. doi: 10.1016/j.ucl.2004.04.020. PMID: 15313054

Prognosis

Posterior urethral valve in thai boys.
Ekarat P, Attawettayanon W, Limratchapong C, Sophark P, Vachvanichsanong P
BMC Pediatr 2023 Sep 7;23(1):445. doi: 10.1186/s12887-023-04281-x. PMID: 37679663Free PMC Article
Association of Analgesic Block With the Incidence of Complications Following Hypospadias Surgery; A Meta-Analysis.
Adler AC, Bhatia VP, Chandrakantan A, Nathanson BH, Ouellette L, Austin PF
Urology 2022 Aug;166:11-17. Epub 2022 Mar 12 doi: 10.1016/j.urology.2022.03.002. PMID: 35292293
Ingrafts in hypospadias surgery: Longer-term outcomes.
Loloi J, Harrington S, Boltz S, Decter RM
J Pediatr Urol 2020 Oct;16(5):555.e1-555.e5. Epub 2020 May 7 doi: 10.1016/j.jpurol.2020.04.030. PMID: 32471708
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988

Clinical prediction guides

Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Zhang Q, Zhang Z, He X, Liu Z, Shen L, Long C, Wei G, Liu X
J Pediatr Urol 2023 Oct;19(5):581.e1-581.e6. Epub 2023 May 13 doi: 10.1016/j.jpurol.2023.05.006. PMID: 37246119
The urethral plate and the underlying tissue; a histological and histochemical study.
Sennert M, Perske C, Wirmer J, Fawzy M, Hadidi AT
J Pediatr Urol 2022 Jun;18(3):364.e1-364.e9. Epub 2022 Feb 16 doi: 10.1016/j.jpurol.2022.02.006. PMID: 35249835
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Epispadias and the associated embryopathies: genetic and developmental basis.
Suzuki K, Matsumaru D, Matsushita S, Murashima A, Ludwig M, Reutter H, Yamada G
Clin Genet 2017 Feb;91(2):247-253. Epub 2016 Oct 10 doi: 10.1111/cge.12871. PMID: 27649475
Recurrent hypospadias surgery.
Barbagli G, Sansalone S, Djinovic R, Lazzeri M
Arch Esp Urol 2014 Jan-Feb;67(1):54-60. PMID: 24531672

Recent systematic reviews

Utility and safety of hyperbaric oxygen therapy as a rescue treatment in complicated cases of hypospadias: A systematic review and meta-analysis.
Anand S, Krishnan N, Bajpai M
J Pediatr Urol 2022 Feb;18(1):39-46. Epub 2021 Oct 20 doi: 10.1016/j.jpurol.2021.10.004. PMID: 34696963
Are there any benefits of using an inlay graft in the treatment of primary hypospadias in children? A systematic review and metanalysis.
Silay MS, 't Hoen L, Bhatt N, Quaedackers J, Bogaert G, Dogan HS, Nijman RJM, Rawashdeh Y, Stein R, Tekgul S, Radmayr C
J Pediatr Urol 2021 Jun;17(3):303-315. Epub 2021 Feb 19 doi: 10.1016/j.jpurol.2021.02.013. PMID: 33691984
State-of-the-Art Renal Imaging in Children.
Viteri B, Calle-Toro JS, Furth S, Darge K, Hartung EA, Otero H
Pediatrics 2020 Feb;145(2) Epub 2020 Jan 8 doi: 10.1542/peds.2019-0829. PMID: 31915193Free PMC Article
Systematic review and meta-analysis of studies comparing the perimeatal-based flap and tubularized incised-plate techniques for primary hypospadias repair.
Wang F, Xu Y, Zhong H
Pediatr Surg Int 2013 Aug;29(8):811-21. Epub 2013 Jun 21 doi: 10.1007/s00383-013-3335-3. PMID: 23793987
Outcomes in distal hypospadias: a systematic review of the Mathieu and tubularized incised plate repairs.
Wilkinson DJ, Farrelly P, Kenny SE
J Pediatr Urol 2012 Jun;8(3):307-12. Epub 2010 Dec 14 doi: 10.1016/j.jpurol.2010.11.008. PMID: 21159560

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