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Dystrophic calcification

MedGen UID:
87170
•Concept ID:
C0333582
•
Finding
Synonyms: Calcareous degeneration; Dystrophic Calcification; Dystrophic calcification, calcified structure; Dystrophic radiographic calcification
SNOMED CT: Dystrophic calcification (60963005); Calcareous degeneration (60963005); Dystrophic calcification (129750001); Dystrophic radiographic calcification (129750001); Dystrophic calcification, calcified structure (60963005)

Definition

Calcium deposits in degenerated or necrotic tissue without abnormalities in blood calcium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDystrophic calcification

Professional guidelines

PubMed

Dermatomyositis-Part 2: Diagnosis, Association With Malignancy, and Treatment.
Ramos-E-Silva M, Lima Pinto AP, Pirmez R, Cuzzi T, Carneiro S
Skinmed 2016;14(5):354-358. Epub 2016 Oct 1 PMID: 27871347
The presentation, assessment, pathogenesis, and treatment of calcinosis in juvenile dermatomyositis.
Hoeltzel MF, Oberle EJ, Robinson AB, Agarwal A, Rider LG
Curr Rheumatol Rep 2014 Dec;16(12):467. doi: 10.1007/s11926-014-0467-y. PMID: 25366934Free PMC Article
Long-term sequelae of cancer treatment on the central nervous system in childhood.
Packer RJ, Meadows AT, Rorke LB, Goldwein JL, D'Angio G
Med Pediatr Oncol 1987;15(5):241-53. doi: 10.1002/mpo.2950150505. PMID: 3309606

Recent clinical studies

Etiology

Stylohyoid Ligament Calcification and Its Association With Dental Diseases.
Al-Amad SH, Al Bayatti S, Alshamsi HA
Int Dent J 2023 Feb;73(1):151-156. Epub 2022 Jul 26 doi: 10.1016/j.identj.2022.06.021. PMID: 35902309Free PMC Article
Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Pseudoxanthoma elasticum.
Germain DP
Orphanet J Rare Dis 2017 May 10;12(1):85. doi: 10.1186/s13023-017-0639-8. PMID: 28486967Free PMC Article
Calcific aortic valve disease: is it another face of atherosclerosis?
Sathyamurthy I, Alex S
Indian Heart J 2015 Sep-Oct;67(5):503-6. Epub 2015 Aug 21 doi: 10.1016/j.ihj.2015.07.033. PMID: 26432749Free PMC Article
Calcinosis cutis: part I. Diagnostic pathway.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E
J Am Acad Dermatol 2011 Jul;65(1):1-12; quiz 13-4. doi: 10.1016/j.jaad.2010.08.038. PMID: 21679810

Diagnosis

Rheumatoid nodules: a narrative review of histopathological progression and diagnostic consideration.
Fareez F, Moodley J, Popovic S, Lu JQ
Clin Rheumatol 2023 Jul;42(7):1753-1765. Epub 2023 Mar 29 doi: 10.1007/s10067-023-06589-6. PMID: 36991243
Hypertrophic cardiomyopathy - phenotypic variations beyond wall thickness.
Goyal N, Keir G, Esterson YB, Saba SG, Cohen S, Rowin E, Romashko M, Chusid J
Clin Imaging 2023 Mar;95:80-89. Epub 2023 Jan 13 doi: 10.1016/j.clinimag.2023.01.003. PMID: 36680913
Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Calcinosis cutis: part I. Diagnostic pathway.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E
J Am Acad Dermatol 2011 Jul;65(1):1-12; quiz 13-4. doi: 10.1016/j.jaad.2010.08.038. PMID: 21679810
Auricular ossification.
Yeatman JM, Varigos GA
Australas J Dermatol 1998 Nov;39(4):268-70. doi: 10.1111/j.1440-0960.1998.tb01489.x. PMID: 9838729

Therapy

SNF472: mechanism of action and results from clinical trials.
Sinha S, Raggi P, Chertow GM
Curr Opin Nephrol Hypertens 2021 Jul 1;30(4):424-429. doi: 10.1097/MNH.0000000000000726. PMID: 34027904
Intense Soft Tissue Calcification of the Head and Neck Following Tracheostomy.
Gozgec E, Ogul H
J Craniofac Surg 2021 Mar-Apr 01;32(2):e145-e147. doi: 10.1097/SCS.0000000000006939. PMID: 33705055
Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Kostyunin AE, Yuzhalin AE, Ovcharenko EA, Kutikhin AG
J Mol Cell Cardiol 2019 Jul;132:189-209. Epub 2019 May 25 doi: 10.1016/j.yjmcc.2019.05.016. PMID: 31136747
Fat necrosis after breast-conserving oncoplastic surgery.
Nakada H, Inoue M, Furuya K, Watanabe H, Ikegame K, Nakayama Y, Ohmori M, Nakagomi H
Breast Cancer 2019 Jan;26(1):125-130. Epub 2018 Aug 27 doi: 10.1007/s12282-018-0901-5. PMID: 30151780
Multimodality imaging of hydrogel scleral buckles.
Ginat DT, Singh AD, Moonis G
Retina 2012 Sep;32(8):1449-52. doi: 10.1097/IAE.0b013e318261a76e. PMID: 22791178

Prognosis

Histopathological Investigation of Dental Pulp Reactions Related to Periodontitis.
Sabeti M, Tayeed H, Kurtzman G, Mashhadi Abbas F, Talebi Ardakani M
Eur Endod J 2021 Aug;6(2):164-169. doi: 10.14744/eej.2021.96268. PMID: 34650012Free PMC Article
Hatched "egg" of thymoma with sarcoidosis.
Hato T, Yamaguchi M, Sugiyama A, Aoki K, Inoue Y, Fukuda H, Gika M, Higashi M, Nakayama M
World J Surg Oncol 2019 Aug 28;17(1):151. doi: 10.1186/s12957-019-1696-3. PMID: 31462247Free PMC Article
Fat necrosis after breast-conserving oncoplastic surgery.
Nakada H, Inoue M, Furuya K, Watanabe H, Ikegame K, Nakayama Y, Ohmori M, Nakagomi H
Breast Cancer 2019 Jan;26(1):125-130. Epub 2018 Aug 27 doi: 10.1007/s12282-018-0901-5. PMID: 30151780
Calcific aortic valve disease: is it another face of atherosclerosis?
Sathyamurthy I, Alex S
Indian Heart J 2015 Sep-Oct;67(5):503-6. Epub 2015 Aug 21 doi: 10.1016/j.ihj.2015.07.033. PMID: 26432749Free PMC Article
Calcinosis cutis: part I. Diagnostic pathway.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E
J Am Acad Dermatol 2011 Jul;65(1):1-12; quiz 13-4. doi: 10.1016/j.jaad.2010.08.038. PMID: 21679810

Clinical prediction guides

Enhanced carbonic anhydrase expression with calcification and fibrosis in bronchial cartilage during COPD.
Nava VE, Khosla R, Shin S, Mordini FE, Bandyopadhyay BC
Acta Histochem 2022 Jan;124(1):151834. Epub 2021 Dec 23 doi: 10.1016/j.acthis.2021.151834. PMID: 34954529Free PMC Article
Dystrophic calcification and respiratory metaplasia in the epithelial lining of odontogenic cysts: a study of 362 odontogenic cysts in a Brazilian population and literature review.
Stuepp RT, Scotti FM, Poletto AG, Rivero ERC, Modolo F
Pathol Res Pract 2020 Jun;216(6):152975. Epub 2020 Apr 18 doi: 10.1016/j.prp.2020.152975. PMID: 32360248
Patterns and pathways of calcification in the developing brain.
McCartney E, Squier W
Dev Med Child Neurol 2014 Oct;56(10):1009-15. Epub 2014 May 21 doi: 10.1111/dmcn.12493. PMID: 24844884
Calcinosis cutis: part I. Diagnostic pathway.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E
J Am Acad Dermatol 2011 Jul;65(1):1-12; quiz 13-4. doi: 10.1016/j.jaad.2010.08.038. PMID: 21679810
Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor?
Das DK
Diagn Cytopathol 2009 Jul;37(7):534-41. doi: 10.1002/dc.21081. PMID: 19373908

Recent systematic reviews

The Association of Dental Pulp Stones to Cardiovascular and Renal Diseases: A Systematic Review and Meta-Analysis.
Almadhoon HW, Al-Kafarna M, Asla MM, Gbreel MI, Abd Allah MAE, Almotairy N
J Endod 2022 Jul;48(7):845-854. Epub 2022 Apr 18 doi: 10.1016/j.joen.2022.02.010. PMID: 35447295
Unicuspid aortic valve in children: a systematic review spanning four decades.
Mookadam F, Thota VR, Lopez AM, Emani UR, Tajik AJ
J Heart Valve Dis 2010 Nov;19(6):678-83. PMID: 21214089
Unicuspid aortic valve in adults: a systematic review.
Mookadam F, Thota VR, Garcia-Lopez AM, Emani UR, Alharthi MS, Zamorano J, Khandheria BK
J Heart Valve Dis 2010 Jan;19(1):79-85. PMID: 20329493

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