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Malignant Neoplasm, Uncertain Whether Primary or Metastatic

MedGen UID:
87196
Concept ID:
C0334224
Neoplastic Process
Synonyms: Malignant tumor - uncertain whether primary or metastatic; Neoplasm, malignant, uncertain whether primary or metastatic; Unclassified tumor, malignant, uncertain whether primary or metastatic
SNOMED CT: Neoplasm, malignant, uncertain whether primary or metastatic (6219000); Unclassified tumor, malignant, uncertain whether primary or metastatic (6219000); Malignant tumor - uncertain whether primary or metastatic (6219000)

Definition

A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm, Uncertain Whether Primary or Metastatic

Professional guidelines

PubMed

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, Bauer JM, Boirie Y, Cruz-Jentoft AJ, Dicker D, Frara S, Frühbeck G, Genton L, Gepner Y, Giustina A, Gonzalez MC, Han HS, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Sieber CC, Siervo M, Vettor R, Villareal DT, Volkert D, Yu J, Zamboni M, Barazzoni R
Obes Facts 2022;15(3):321-335. Epub 2022 Feb 23 doi: 10.1159/000521241. PMID: 35196654Free PMC Article
Vuurberg G, Hoorntje A, Wink LM, van der Doelen BFW, van den Bekerom MP, Dekker R, van Dijk CN, Krips R, Loogman MCM, Ridderikhof ML, Smithuis FF, Stufkens SAS, Verhagen EALM, de Bie RA, Kerkhoffs GMMJ
Br J Sports Med 2018 Aug;52(15):956. Epub 2018 Mar 7 doi: 10.1136/bjsports-2017-098106. PMID: 29514819

Recent clinical studies

Etiology

Kurian AW, Abrahamse P, Furgal A, Ward KC, Hamilton AS, Hodan R, Tocco R, Liu L, Berek JS, Hoang L, Yussuf A, Susswein L, Esplin ED, Slavin TP, Gomez SL, Hofer TP, Katz SJ
JAMA 2023 Jul 3;330(1):43-51. doi: 10.1001/jama.2023.9526. PMID: 37276540Free PMC Article
Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, Goldberg J, Al Baghdadi T, Goodman KA, McWilliams RR, Farma JM, George TJ, Kennecke HF, Shergill A, Montemurro M, Nelson GD, Colgrove B, Gordon V, Venook AP, O'Reilly EM, Meyerhardt JA, Dueck AC, Basch E, Chang GJ, Mamon HJ
N Engl J Med 2023 Jul 27;389(4):322-334. Epub 2023 Jun 4 doi: 10.1056/NEJMoa2303269. PMID: 37272534Free PMC Article
Yuan S, Chen J, Ruan X, Sun Y, Zhang K, Wang X, Li X, Gill D, Burgess S, Giovannucci E, Larsson SC
Elife 2023 Feb 2;12 doi: 10.7554/eLife.84051. PMID: 36727839Free PMC Article
Aminian A, Wilson R, Al-Kurd A, Tu C, Milinovich A, Kroh M, Rosenthal RJ, Brethauer SA, Schauer PR, Kattan MW, Brown JC, Berger NA, Abraham J, Nissen SE
JAMA 2022 Jun 28;327(24):2423-2433. doi: 10.1001/jama.2022.9009. PMID: 35657620Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article

Diagnosis

Kurian AW, Abrahamse P, Furgal A, Ward KC, Hamilton AS, Hodan R, Tocco R, Liu L, Berek JS, Hoang L, Yussuf A, Susswein L, Esplin ED, Slavin TP, Gomez SL, Hofer TP, Katz SJ
JAMA 2023 Jul 3;330(1):43-51. doi: 10.1001/jama.2023.9526. PMID: 37276540Free PMC Article
Qiao H, Tan XR, Li H, Li JY, Chen XZ, Li YQ, Li WF, Tang LL, Zhou GQ, Zhang Y, Liang YL, He QM, Zhao Y, Huang SY, Gong S, Li Q, Ye ML, Chen KL, Sun Y, Ma J, Liu N
JAMA Oncol 2022 Sep 1;8(9):1301-1309. doi: 10.1001/jamaoncol.2022.2810. PMID: 35834269Free PMC Article
Bosteels J, van Wessel S, Weyers S, Broekmans FJ, D'Hooghe TM, Bongers MY, Mol BWJ
Cochrane Database Syst Rev 2018 Dec 5;12(12):CD009461. doi: 10.1002/14651858.CD009461.pub4. PMID: 30521679Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

Therapy

Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Minneci PC, Deans KJ
Semin Pediatr Surg 2018 Dec;27(6):332-337. Epub 2018 Oct 24 doi: 10.1053/j.sempedsurg.2018.10.003. PMID: 30473036
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

Prognosis

Wong MCS, Huang J, Chan PSF, Choi P, Lao XQ, Chan SM, Teoh A, Liang P
JAMA Netw Open 2021 Jul 1;4(7):e2118457. doi: 10.1001/jamanetworkopen.2021.18457. PMID: 34309666Free PMC Article
Ripollés-Melchor J, Ramírez-Rodríguez JM, Casans-Francés R, Aldecoa C, Abad-Motos A, Logroño-Egea M, García-Erce JA, Camps-Cervantes Á, Ferrando-Ortolá C, Suarez de la Rica A, Cuellar-Martínez A, Marmaña-Mezquita S, Abad-Gurumeta A, Calvo-Vecino JM; POWER Study Investigators Group for the Spanish Perioperative Audit and Research Network (REDGERM)
JAMA Surg 2019 Aug 1;154(8):725-736. doi: 10.1001/jamasurg.2019.0995. PMID: 31066889Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Chamberlain MC
J Clin Oncol 2005 May 20;23(15):3605-13. doi: 10.1200/JCO.2005.01.131. PMID: 15908671
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107

Clinical prediction guides

Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Dunne EM, Sahgal A, Lo SS, Bergman A, Kosztyla R, Dea N, Chang EL, Chang UK, Chao ST, Faruqi S, Ghia AJ, Redmond KJ, Soltys SG, Liu MC
Radiother Oncol 2020 Apr;145:21-29. Epub 2019 Dec 23 doi: 10.1016/j.radonc.2019.11.026. PMID: 31874346
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H
Cochrane Database Syst Rev 2019 Jul 2;7(7):CD007689. doi: 10.1002/14651858.CD007689.pub4. PMID: 31264709Free PMC Article
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article
Jin X, Ruiz Beguerie J, Sze DM, Chan GC
Cochrane Database Syst Rev 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603Free PMC Article

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