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Mucin-producing carcinoma

MedGen UID:
87225
•Concept ID:
C0334368
•
Neoplastic Process
Synonyms: Mucin-Producing Adenocarcinoma; Mucin-producing adenocarcinoma; Mucin-Producing Carcinoma; mucin-producing carcinoma; Mucin-secreting adenocarcinoma; Mucin-secreting carcinoma
SNOMED CT: Mucin-producing adenocarcinoma (900006); Mucin-producing carcinoma (900006); Mucin-secreting adenocarcinoma (900006); Mucin-secreting carcinoma (900006)
 
Monarch Initiative: MONDO:0020596

Definition

A carcinoma that produces mucin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucin-producing carcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome.
Hodgson A, Olkhov-Mitsel E, Howitt BE, Nucci MR, Parra-Herran C
J Clin Pathol 2019 May;72(5):347-353. Epub 2019 Jan 24 doi: 10.1136/jclinpath-2018-205632. PMID: 30679193
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Invasive stratified mucin-producing carcinoma of the colorectum: expanding the morphologic spectrum of large bowel cancer.
Auld FM, Moyana TN
Diagn Pathol 2023 Oct 18;18(1):113. doi: 10.1186/s13000-023-01396-8. PMID: 37853375Free PMC Article
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Uterine Cervix: Clinicopathological and Molecular Characteristics With Special Emphasis on the First Description of Consistent Programmed Death-ligand 1 (PD-L1) Over-expression.
Choi S, Kim SW, Kim HS
Cancer Genomics Proteomics 2021 Sep-Oct;18(5):685-698. doi: 10.21873/cgp.20290. PMID: 34479920Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Diagnosis

A review of mucinous lesions of the breast.
Ginter PS, Tang X, Shin SJ
Breast J 2020 Jun;26(6):1168-1178. Epub 2020 May 18 doi: 10.1111/tbj.13878. PMID: 32419267
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity.
Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ
Am J Surg Pathol 2020 Jul;44(7):873-880. doi: 10.1097/PAS.0000000000001480. PMID: 32235154Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
An Update of Mucinous Lesions of the Breast.
Harrison BT, Dillon DA
Surg Pathol Clin 2018 Mar;11(1):61-90. Epub 2017 Dec 6 doi: 10.1016/j.path.2017.09.002. PMID: 29413660
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Therapy

Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Uterine Cervix: Clinicopathological and Molecular Characteristics With Special Emphasis on the First Description of Consistent Programmed Death-ligand 1 (PD-L1) Over-expression.
Choi S, Kim SW, Kim HS
Cancer Genomics Proteomics 2021 Sep-Oct;18(5):685-698. doi: 10.21873/cgp.20290. PMID: 34479920Free PMC Article
Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis.
Noda H, Chiba F, Toyama N, Konishi F
J Hepatobiliary Pancreat Surg 2009;16(1):83-5. Epub 2008 Dec 19 doi: 10.1007/s00534-008-0001-6. PMID: 19096754
Clinicopathologic characteristics of large bowel cancer developing after radiotherapy for uterine cervical cancer.
Shirouzu K, Isomoto H, Morodomi T, Ogata Y, Araki Y, Kakegawa T
Dis Colon Rectum 1994 Dec;37(12):1245-9. doi: 10.1007/BF02257790. PMID: 7995152

Prognosis

Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive stratified mucin-producing carcinoma: a clinicopathological analysis of three cases.
Lei R
Cancer Biol Ther 2019;20(11):1403-1407. Epub 2019 Jul 30 doi: 10.1080/15384047.2019.1647054. PMID: 31362570Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368

Clinical prediction guides

Cervical Adenocarcinoma: A Still Under-investigated Malignancy.
Pistolesi S, Fanelli GN, Giudice F, Garbini F, Naccarato AG, Cosio S, Caretto M, Gadducci A
Anticancer Res 2023 Jan;43(1):53-58. doi: 10.21873/anticanres.16133. PMID: 36585201
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Uterine Cervix: Clinicopathological and Molecular Characteristics With Special Emphasis on the First Description of Consistent Programmed Death-ligand 1 (PD-L1) Over-expression.
Choi S, Kim SW, Kim HS
Cancer Genomics Proteomics 2021 Sep-Oct;18(5):685-698. doi: 10.21873/cgp.20290. PMID: 34479920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368

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