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Malignant Skin Appendage Neoplasm

MedGen UID:
87563
•Concept ID:
C0346770
•
Neoplastic Process
Synonyms: Malignant Cutaneous Adnexal Neoplasm; Malignant Epidermal Appendage Neoplasm; Malignant Epidermal Appendage Tumor; Malignant Neoplasm of Epidermal Appendage; Malignant Neoplasm of the Epidermal Appendage; Malignant Skin Adnexal Neoplasm; Malignant Skin Adnexal Tumor; Malignant skin tumor with adnexal differentiation; Malignant tumor of epidermal appendage; Malignant Tumor of Epidermal Appendage; Malignant Tumor of the Epidermal Appendage
SNOMED CT: Malignant skin tumor with adnexal differentiation (255093003); Malignant tumor of epidermal appendage (255093003)

Definition

A malignant neoplasm that arises from the skin appendages. [from NCI]

Professional guidelines

PubMed

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696
Restorative oncodermatology: Diagnosis and management of dermatologic sequelae from cancer therapies.
Rossi AM, Hibler BP, Navarrete-Dechent C, Lacouture ME
J Am Acad Dermatol 2021 Sep;85(3):693-707. Epub 2020 Aug 8 doi: 10.1016/j.jaad.2020.08.005. PMID: 32781177Free PMC Article
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650

Recent clinical studies

Etiology

Immune checkpoint inhibitor-related dermatologic adverse events.
Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, Kern JA, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1255-1268. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.03.132. PMID: 32454097Free PMC Article
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588

Diagnosis

Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Therapy

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.
Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723Free PMC Article
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Immune checkpoint inhibitor-related dermatologic adverse events.
Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, Kern JA, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1255-1268. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.03.132. PMID: 32454097Free PMC Article
Dermatologic infections in cancer patients.
Gandhi M, Brieva JC, Lacouture ME
Cancer Treat Res 2014;161:299-317. doi: 10.1007/978-3-319-04220-6_10. PMID: 24706229

Prognosis

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Vulvar cancer: a review for dermatologists.
Chokoeva AA, Tchernev G, Castelli E, Orlando E, Verma SB, Grebe M, Wollina U
Wien Med Wochenschr 2015 Apr;165(7-8):164-77. Epub 2015 May 1 doi: 10.1007/s10354-015-0354-9. PMID: 25930015
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Clinical prediction guides

Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review.
Baykal C, Atcı T, Yılmaz Z, Büyükbabani N
J Cutan Pathol 2021 Jul;48(7):884-895. Epub 2021 Mar 9 doi: 10.1111/cup.13979. PMID: 33569789
Recent developments in dermoscopy for dermatology.
Chen X, Lu Q, Chen C, Jiang G
J Cosmet Dermatol 2021 Jun;20(6):1611-1617. Epub 2020 Nov 28 doi: 10.1111/jocd.13846. PMID: 33197276
Dermoscopy of genital diseases: a review.
Lacarrubba F, Borghi A, Verzì AE, Corazza M, Stinco G, Micali G
J Eur Acad Dermatol Venereol 2020 Oct;34(10):2198-2207. Epub 2020 Jul 13 doi: 10.1111/jdv.16723. PMID: 32531092
High frequency ultrasound with color Doppler in dermatology.
Barcaui Ede O, Carvalho AC, Lopes FP, Piñeiro-Maceira J, Barcaui CB
An Bras Dermatol 2016 May-Jun;91(3):262-73. doi: 10.1590/abd1806-4841.20164446. PMID: 27438191Free PMC Article
Gender-linked differences in human skin.
Giacomoni PU, Mammone T, Teri M
J Dermatol Sci 2009 Sep;55(3):144-9. Epub 2009 Jul 1 doi: 10.1016/j.jdermsci.2009.06.001. PMID: 19574028

Recent systematic reviews

Epidemiology, clinical characteristics, treatment, and outcomes of proliferating pilar tumors: A systematic review.
Nemeh MN, Curtiss P, Nijhawan RI
J Am Acad Dermatol 2024 Jan;90(1):122-124. Epub 2023 Jun 24 doi: 10.1016/j.jaad.2023.05.097. PMID: 37364614
Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review.
Osto M, Parry N, Rehman R, Ahmed U, Mehregan D
Am J Dermatopathol 2021 Dec 1;43(12):851-866. doi: 10.1097/DAD.0000000000001991. PMID: 34797787
Management of multiple trichoepithelioma: A review of pharmacological therapies.
Lobo Y, Blake T, Wheller L
Australas J Dermatol 2021 May;62(2):e192-e200. Epub 2021 Jan 5 doi: 10.1111/ajd.13537. PMID: 33403677

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