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Malignant Neoplasm of Multiple Primary Sites

MedGen UID:
87640
•Concept ID:
C0362051
•
Neoplastic Process
Synonyms: Malignant neoplasms of independent primary multiple sites; Primary malignant neoplasm of independent multiple sites; Primary multicentric tumor
SNOMED CT: Primary malignant neoplasm of independent multiple sites (109359008); Primary multicentric tumor (109359008); Malignant neoplasms of independent primary multiple sites (109359008)

Definition

A malignant neoplasm arising in multiple primary sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm of Multiple Primary Sites

Professional guidelines

PubMed

Mechanisms, Diagnosis and Treatment of Bone Metastases.
Ban J, Fock V, Aryee DNT, Kovar H
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112944. PMID: 34831167Free PMC Article
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions.
Kamaya A, Weinstein S, Desser TS
Semin Ultrasound CT MR 2006 Oct;27(5):389-403. doi: 10.1053/j.sult.2006.06.004. PMID: 17048454

Recent clinical studies

Etiology

Multiple primary head and neck squamous cell cancer: Lessons learnt.
Ghogale KS, Naorem R, Waghmare CM
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S658-S663. Epub 2023 May 2 doi: 10.4103/jcrt.jcrt_392_22. PMID: 38384035
Distribution and Surgical Management of Visceral Ewing Sarcoma Among Children and Adolescents.
Wallace MW, Niec JA, Ghani MOA, McKay KG, Idrees K, Liang J, Borinstein SC, Lovvorn HN 3rd
J Pediatr Surg 2023 Sep;58(9):1727-1735. Epub 2023 Jan 14 doi: 10.1016/j.jpedsurg.2023.01.006. PMID: 36774201
Epidemiology of bone metastases.
Ryan C, Stoltzfus KC, Horn S, Chen H, Louie AV, Lehrer EJ, Trifiletti DM, Fox EJ, Abraham JA, Zaorsky NG
Bone 2022 May;158:115783. Epub 2020 Dec 1 doi: 10.1016/j.bone.2020.115783. PMID: 33276151
Use of Multi-Site Radiation Therapy for Systemic Disease Control.
Patel RR, Verma V, Barsoumian HB, Ning MS, Chun SG, Tang C, Chang JY, Lee PP, Gandhi S, Balter P, Dunn JD, Chen D, Puebla-Osorio N, Cortez MA, Welsh JW
Int J Radiat Oncol Biol Phys 2021 Feb 1;109(2):352-364. Epub 2020 Aug 13 doi: 10.1016/j.ijrobp.2020.08.025. PMID: 32798606Free PMC Article
Temporal trends in the risk of developing multiple primary cancers: a systematic review.
Ye Y, Neil AL, Wills KE, Venn AJ
BMC Cancer 2016 Nov 4;16(1):849. doi: 10.1186/s12885-016-2876-y. PMID: 27814758Free PMC Article

Diagnosis

Epidemiology of bone metastases.
Ryan C, Stoltzfus KC, Horn S, Chen H, Louie AV, Lehrer EJ, Trifiletti DM, Fox EJ, Abraham JA, Zaorsky NG
Bone 2022 May;158:115783. Epub 2020 Dec 1 doi: 10.1016/j.bone.2020.115783. PMID: 33276151
A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.
Feller L, Khammissa RAG, Lemmer J
ScientificWorldJournal 2017;2017:9189812. Epub 2017 May 30 doi: 10.1155/2017/9189812. PMID: 28638859Free PMC Article
Immunodeficiency-associated lymphoproliferative disorders.
Knowles DM
Mod Pathol 1999 Feb;12(2):200-17. PMID: 10071343
Pseudomyxoma peritonei.
Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579
Tumor antigens.
Urban JL, Schreiber H
Annu Rev Immunol 1992;10:617-44. doi: 10.1146/annurev.iy.10.040192.003153. PMID: 1590998

Therapy

Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study.
Qin S, Chan SL, Gu S, Bai Y, Ren Z, Lin X, Chen Z, Jia W, Jin Y, Guo Y, Hu X, Meng Z, Liang J, Cheng Y, Xiong J, Ren H, Yang F, Li W, Chen Y, Zeng Y, Sultanbaev A, Pazgan-Simon M, Pisetska M, Melisi D, Ponomarenko D, Osypchuk Y, Sinielnikov I, Yang TS, Liang X, Chen C, Wang L, Cheng AL, Kaseb A, Vogel A; CARES-310 Study Group
Lancet 2023 Sep 30;402(10408):1133-1146. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00961-3. PMID: 37499670
Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial.
Tang C, Sherry AD, Haymaker C, Bathala T, Liu S, Fellman B, Cohen L, Aparicio A, Zurita AJ, Reuben A, Marmonti E, Chun SG, Reddy JP, Ghia A, McGuire S, Efstathiou E, Wang J, Wang J, Pilie P, Kovitz C, Du W, Simiele SJ, Kumar R, Borghero Y, Shi Z, Chapin B, Gomez D, Wistuba I, Corn PG
JAMA Oncol 2023 Jun 1;9(6):825-834. doi: 10.1001/jamaoncol.2023.0161. PMID: 37022702Free PMC Article
Mechanisms, Diagnosis and Treatment of Bone Metastases.
Ban J, Fock V, Aryee DNT, Kovar H
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112944. PMID: 34831167Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article

Prognosis

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2).
Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.
Feller L, Khammissa RAG, Lemmer J
ScientificWorldJournal 2017;2017:9189812. Epub 2017 May 30 doi: 10.1155/2017/9189812. PMID: 28638859Free PMC Article
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Clinical prediction guides

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article
Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection.
Smalley SR, Benedetti JK, Haller DG, Hundahl SA, Estes NC, Ajani JA, Gunderson LL, Goldman B, Martenson JA, Jessup JM, Stemmermann GN, Blanke CD, Macdonald JS
J Clin Oncol 2012 Jul 1;30(19):2327-33. Epub 2012 May 14 doi: 10.1200/JCO.2011.36.7136. PMID: 22585691Free PMC Article

Recent systematic reviews

Systematic review of fetal and placental metastases among pregnant patients with cancer.
Khazzaka A, Rassy E, Sleiman Z, Boussios S, Pavlidis N
Cancer Treat Rev 2022 Mar;104:102356. Epub 2022 Feb 11 doi: 10.1016/j.ctrv.2022.102356. PMID: 35182890
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.
Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA
Radiother Oncol 2020 Jul;148:157-166. Epub 2020 Apr 22 doi: 10.1016/j.radonc.2020.04.003. PMID: 32388150
Temporal trends in the risk of developing multiple primary cancers: a systematic review.
Ye Y, Neil AL, Wills KE, Venn AJ
BMC Cancer 2016 Nov 4;16(1):849. doi: 10.1186/s12885-016-2876-y. PMID: 27814758Free PMC Article
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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