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Leptospirosis Nephropathy

MedGen UID:
881933
•Concept ID:
C4054651
•
Disease or Syndrome

Definition

Interstitial nephritis due to Leptospira, which may be associated with non-oliguric acute kidney injury. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeptospirosis Nephropathy

Professional guidelines

PubMed

Severe leptospirosis in tropical Australia: Optimising intensive care unit management to reduce mortality.
Smith S, Liu YH, Carter A, Kennedy BJ, Dermedgoglou A, Poulgrain SS, Paavola MP, Minto TL, Luc M, Hanson J
PLoS Negl Trop Dis 2019 Dec;13(12):e0007929. Epub 2019 Dec 2 doi: 10.1371/journal.pntd.0007929. PMID: 31790405Free PMC Article
Acute kidney injury in leptospirosis: the Kidney Disease Improving Global Outcomes (KDIGO) criteria and mortality
.
Teles F, de Mendonça Uchôa JV, Mirelli Barreto Mendonça D, Falcão Pedrosa Costa A
Clin Nephrol 2016 Dec;86 (2016)(12):303-309. doi: 10.5414/CN108865. PMID: 27805562
Renal involvement in leptospirosis--new insights into pathophysiology and treatment.
Cerqueira TB, Athanazio DA, Spichler AS, Seguro AC
Braz J Infect Dis 2008 Jun;12(3):248-52. doi: 10.1590/s1413-86702008000300016. PMID: 18833411

Recent clinical studies

Etiology

Infections and Acute Kidney Injury: A Global Perspective.
Batte A, Shahrin L, Claure-Del Granado R, Luyckx VA, Conroy AL
Semin Nephrol 2023 Sep;43(5):151466. Epub 2023 Dec 28 doi: 10.1016/j.semnephrol.2023.151466. PMID: 38158245
Leptospirosis kidney disease: Evolution from acute to chronic kidney disease.
Chou LF, Yang HY, Hung CC, Tian YC, Hsu SH, Yang CW
Biomed J 2023 Aug;46(4):100595. Epub 2023 May 2 doi: 10.1016/j.bj.2023.100595. PMID: 37142093Free PMC Article
Community-Acquired AKI in Asia: An Update.
Kumar V, Jha V
Semin Nephrol 2020 Sep;40(5):456-467. doi: 10.1016/j.semnephrol.2020.08.002. PMID: 33334459
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review.
Karpagam KB, Ganesh B
Eur J Clin Microbiol Infect Dis 2020 May;39(5):835-846. Epub 2020 Jan 2 doi: 10.1007/s10096-019-03797-4. PMID: 31898795
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642

Diagnosis

Understanding the Renal Fibrotic Process in Leptospirosis.
Prado LG, Barbosa AS
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910779. PMID: 34639117Free PMC Article
A Treacherous Course.
Little J, Vaidya A, Jilg N, Lau E, Baker M
N Engl J Med 2021 Feb 4;384(5):e10. doi: 10.1056/NEJMimc2026145. PMID: 33534978
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review.
Karpagam KB, Ganesh B
Eur J Clin Microbiol Infect Dis 2020 May;39(5):835-846. Epub 2020 Jan 2 doi: 10.1007/s10096-019-03797-4. PMID: 31898795
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642
Leptospirosis renal disease.
Yang CW, Wu MS, Pan MJ
Nephrol Dial Transplant 2001;16 Suppl 5:73-7. doi: 10.1093/ndt/16.suppl_5.73. PMID: 11509689

Therapy

A Treacherous Course.
Little J, Vaidya A, Jilg N, Lau E, Baker M
N Engl J Med 2021 Feb 4;384(5):e10. doi: 10.1056/NEJMimc2026145. PMID: 33534978
Infections and the kidney: a tale from the tropics.
Kamath N, Iyengar A
Pediatr Nephrol 2018 Aug;33(8):1317-1326. Epub 2017 Sep 6 doi: 10.1007/s00467-017-3785-2. PMID: 28879600
The kidney in leptospirosis.
Abdulkader RC, Silva MV
Pediatr Nephrol 2008 Dec;23(12):2111-20. Epub 2008 Apr 30 doi: 10.1007/s00467-008-0811-4. PMID: 18446381
Leptospirosis renal disease.
Yang CW, Wu MS, Pan MJ
Nephrol Dial Transplant 2001;16 Suppl 5:73-7. doi: 10.1093/ndt/16.suppl_5.73. PMID: 11509689
Bovine leptospirosis.
Hanson LE
J Dairy Sci 1976 Jun;59(6):1166-70. doi: 10.3168/jds.S0022-0302(76)84339-1. PMID: 58876

Prognosis

Hemoperfusion in Leptospirosis.
Danguilan RA
Contrib Nephrol 2023;200:252-261. Epub 2023 Jun 1 doi: 10.1159/000527571. PMID: 37263231
A Treacherous Course.
Little J, Vaidya A, Jilg N, Lau E, Baker M
N Engl J Med 2021 Feb 4;384(5):e10. doi: 10.1056/NEJMimc2026145. PMID: 33534978
Community-Acquired AKI in Asia: An Update.
Kumar V, Jha V
Semin Nephrol 2020 Sep;40(5):456-467. doi: 10.1016/j.semnephrol.2020.08.002. PMID: 33334459
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642
Leptospiral nephropathy.
Sitprija V, Losuwanrak K, Kanjanabuch T
Semin Nephrol 2003 Jan;23(1):42-8. doi: 10.1053/snep.2003.50004. PMID: 12563600

Clinical prediction guides

Chronic Interstitial Nephritis in Agricultural Communities (CINAC) in Sri Lanka.
Jayasumana C
Semin Nephrol 2019 May;39(3):278-283. doi: 10.1016/j.semnephrol.2019.02.006. PMID: 31054627
Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology.
Yang CW
Nephron 2018;138(2):129-136. Epub 2017 Sep 20 doi: 10.1159/000480691. PMID: 28926845
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642
Nephropathy in leptospirosis.
Visith S, Kearkiat P
J Postgrad Med 2005 Jul-Sep;51(3):184-8. PMID: 16333190
Leptospiral nephropathy.
Sitprija V, Losuwanrak K, Kanjanabuch T
Semin Nephrol 2003 Jan;23(1):42-8. doi: 10.1053/snep.2003.50004. PMID: 12563600

Recent systematic reviews

Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review.
Charles JC, Jayarajah U, Subasinghe D
J Int Med Res 2023 Sep;51(9):3000605231197461. doi: 10.1177/03000605231197461. PMID: 37776529Free PMC Article
Leptospiral infection in domestic cats: Systematic review with meta-analysis.
Ricardo T, Azócar-Aedo L, Signorini M, Previtali MA
Prev Vet Med 2023 Mar;212:105851. Epub 2023 Jan 18 doi: 10.1016/j.prevetmed.2023.105851. PMID: 36706556
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies.
Carrillo-Larco RM, Altez-Fernandez C, Acevedo-Rodriguez JG, Ortiz-Acha K, Ugarte-Gil C
PLoS Negl Trop Dis 2019 May;13(5):e0007458. Epub 2019 May 23 doi: 10.1371/journal.pntd.0007458. PMID: 31120876Free PMC Article
A Systematic Review of the Mortality from Untreated Leptospirosis.
Taylor AJ, Paris DH, Newton PN
PLoS Negl Trop Dis 2015;9(6):e0003866. Epub 2015 Jun 25 doi: 10.1371/journal.pntd.0003866. PMID: 26110270Free PMC Article
Escalating chronic kidney diseases of multi-factorial origin in Sri Lanka: causes, solutions, and recommendations.
Wimalawansa SJ
Environ Health Prev Med 2014 Nov;19(6):375-94. Epub 2014 Sep 20 doi: 10.1007/s12199-014-0395-5. PMID: 25239006Free PMC Article

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