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Acquired Hypogonadotropic Hypogonadism

MedGen UID:
882264
•Concept ID:
C4055502
•
Disease or Syndrome

Definition

Hypogonadotropic hypogonadism, the cause of which is not present from birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcquired Hypogonadotropic Hypogonadism

Professional guidelines

PubMed

Treatment of infertility with hypogonadotropic hypogonadism: 10-year experience in Auckland, New Zealand.
Milsom S, Duggan K, O'sullivan S, Ogilvie M, Gunn AJ
Aust N Z J Obstet Gynaecol 2012 Jun;52(3):293-8. doi: 10.1111/j.1479-828X.2012.01450.x. PMID: 22694078
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment.
Salenave S, Trabado S, Maione L, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2012 Apr;73(2):141-6. Epub 2012 Apr 25 doi: 10.1016/j.ando.2012.03.040. PMID: 22541999

Recent clinical studies

Etiology

Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH).
De Sanctis V, Daar S, Soliman A, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Aug 3;94(4):e2023195. doi: 10.23750/abm.v94i4.14631. PMID: 37539597Free PMC Article
Assessment of glucose homeostasis in young adult female β-thalassemia major patients (β-TM) with acquired hypogonadotropic hypogonadism (AHH) never treated with sex steroids compared to eugonadal β-TM patients with spontaneous menstrual cycles.
De Sanctis V, Daar S, Soliman AT, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Jun 14;94(3):e2023065. doi: 10.23750/abm.v94i3.14147. PMID: 37326269Free PMC Article
Thyroid function in Klinefelter syndrome: a multicentre study from KING group.
Balercia G, Bonomi M, Giagulli VA, Lanfranco F, Rochira V, Giambersio A, Accardo G, Esposito D, Allasia S, Cangiano B, De Vincentis S, Condorelli RA, Calogero A, Pasquali D; KING group
J Endocrinol Invest 2019 Oct;42(10):1199-1204. Epub 2019 Mar 25 doi: 10.1007/s40618-019-01037-2. PMID: 30912057
Organic causes of erectile dysfunction in men under 40.
Ludwig W, Phillips M
Urol Int 2014;92(1):1-6. Epub 2013 Nov 21 doi: 10.1159/000354931. PMID: 24281298
Testicular findings, endocrine features and therapeutic responses of men with acquired hypogonadotropic hypogonadism.
Tachiki H, Ito N, Maruta H, Kumamoto Y, Tsukamoto T
Int J Urol 1998 Jan;5(1):80-5. doi: 10.1111/j.1442-2042.1998.tb00244.x. PMID: 9535606

Diagnosis

Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH).
De Sanctis V, Daar S, Soliman A, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Aug 3;94(4):e2023195. doi: 10.23750/abm.v94i4.14631. PMID: 37539597Free PMC Article
Reproductive Phenotypes in Men With Acquired or Congenital Hypogonadotropic Hypogonadism: A Comparative Study.
Maione L, Sarfati J, Gonfroy-Leymarie C, Salenave S, Brailly-Tabard S, Chanson P, Trabado S, Kaiser UB, Young J
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2812-e2824. doi: 10.1210/clinem/dgac194. PMID: 35358314Free PMC Article
Organic causes of erectile dysfunction in men under 40.
Ludwig W, Phillips M
Urol Int 2014;92(1):1-6. Epub 2013 Nov 21 doi: 10.1159/000354931. PMID: 24281298
Hypogonadotropic hypogonadism revisited.
Fraietta R, Zylberstejn DS, Esteves SC
Clinics (Sao Paulo) 2013;68 Suppl 1(Suppl 1):81-8. doi: 10.6061/clinics/2013(sup01)09. PMID: 23503957Free PMC Article
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment.
Salenave S, Trabado S, Maione L, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2012 Apr;73(2):141-6. Epub 2012 Apr 25 doi: 10.1016/j.ando.2012.03.040. PMID: 22541999

Therapy

Assessment of glucose homeostasis in young adult female β-thalassemia major patients (β-TM) with acquired hypogonadotropic hypogonadism (AHH) never treated with sex steroids compared to eugonadal β-TM patients with spontaneous menstrual cycles.
De Sanctis V, Daar S, Soliman AT, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Jun 14;94(3):e2023065. doi: 10.23750/abm.v94i3.14147. PMID: 37326269Free PMC Article
Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism.
Giagulli VA, Carbone MD, Ramunni MI, Licchelli B, De Pergola G, Sabbà C, Guastamacchia E, Triggiani V
Andrology 2015 Nov;3(6):1094-103. Epub 2015 Oct 7 doi: 10.1111/andr.12099. PMID: 26447645
Men with acquired hypogonadotropic hypogonadism treated with testosterone may be fertile.
Drincic A, Arseven OK, Sosa E, Mercado M, Kopp P, Molitch ME
Pituitary 2003;6(1):5-10. doi: 10.1023/a:1026232124988. PMID: 14674718
Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions.
Young J, Couzinet B, Chanson P, Brailly S, Loumaye E, Schaison G
J Clin Endocrinol Metab 2000 Sep;85(9):3239-44. doi: 10.1210/jcem.85.9.6811. PMID: 10999815
Testicular findings, endocrine features and therapeutic responses of men with acquired hypogonadotropic hypogonadism.
Tachiki H, Ito N, Maruta H, Kumamoto Y, Tsukamoto T
Int J Urol 1998 Jan;5(1):80-5. doi: 10.1111/j.1442-2042.1998.tb00244.x. PMID: 9535606

Prognosis

Reproductive Phenotypes in Men With Acquired or Congenital Hypogonadotropic Hypogonadism: A Comparative Study.
Maione L, Sarfati J, Gonfroy-Leymarie C, Salenave S, Brailly-Tabard S, Chanson P, Trabado S, Kaiser UB, Young J
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2812-e2824. doi: 10.1210/clinem/dgac194. PMID: 35358314Free PMC Article
Organic causes of erectile dysfunction in men under 40.
Ludwig W, Phillips M
Urol Int 2014;92(1):1-6. Epub 2013 Nov 21 doi: 10.1159/000354931. PMID: 24281298
Prospective evaluation of risk factors for exercise-induced hypogonadism in male runners.
Skarda ST, Burge MR
West J Med 1998 Jul;169(1):9-12. PMID: 9682624Free PMC Article

Clinical prediction guides

Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH).
De Sanctis V, Daar S, Soliman A, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Aug 3;94(4):e2023195. doi: 10.23750/abm.v94i4.14631. PMID: 37539597Free PMC Article
Assessment of glucose homeostasis in young adult female β-thalassemia major patients (β-TM) with acquired hypogonadotropic hypogonadism (AHH) never treated with sex steroids compared to eugonadal β-TM patients with spontaneous menstrual cycles.
De Sanctis V, Daar S, Soliman AT, Tzoulis P, Di Maio S, Kattamis C
Acta Biomed 2023 Jun 14;94(3):e2023065. doi: 10.23750/abm.v94i3.14147. PMID: 37326269Free PMC Article
Reproductive Phenotypes in Men With Acquired or Congenital Hypogonadotropic Hypogonadism: A Comparative Study.
Maione L, Sarfati J, Gonfroy-Leymarie C, Salenave S, Brailly-Tabard S, Chanson P, Trabado S, Kaiser UB, Young J
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2812-e2824. doi: 10.1210/clinem/dgac194. PMID: 35358314Free PMC Article
Organic causes of erectile dysfunction in men under 40.
Ludwig W, Phillips M
Urol Int 2014;92(1):1-6. Epub 2013 Nov 21 doi: 10.1159/000354931. PMID: 24281298
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment.
Salenave S, Trabado S, Maione L, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2012 Apr;73(2):141-6. Epub 2012 Apr 25 doi: 10.1016/j.ando.2012.03.040. PMID: 22541999

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